Cell Biology

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Researchers cultivate vascular organoids that perfectly mimic human blood vessels

For the first time, researchers have successfully cultivated “vascular organoids” in a petri dish that perfectly mimic real human blood vessels.

16 Jan 2019

Researchers demonstrate how manganese produces parkinsonian syndrome

Using X-ray fluorescence at synchrotrons DESY and ESRF, researchers in the Centre d'Etudes Nucléaires de Bordeaux Gradignan have demonstrated the consequences of a mutation responsible for a hereditary parkinsonian syndrome: accumulated manganese in the cells appears to disturb protein transport.

16 Jan 2019

Breast cancer cells in mice coaxed to turn into harmless fat cells

As cancer cells respond to cues in their microenvironment, they can enter a highly plastic state in which they are susceptible to transdifferentiation into a different type of cell.

16 Jan 2019

Truncal mutations study suggests new direction in origins of cancer

Cancers most commonly arise because of a series of two to five mutations in different genes that combine to cause a tumor.

16 Jan 2019

LifeTime receives fund to develop a plan to embed its vision for healthier future

Our body's cells are constantly changing. But which of these changes are healthy developments and which lead to serious diseases? This is what LifeTime, a new transnational and interdisciplinary initiative of leading European researchers, aims to discover.

16 Jan 2019

DNA may help predict potential life expectancy of a person, report scientists

Scientists say they can predict whether a person can expect to live longer or die sooner than average, by looking at their DNA.

16 Jan 2019

Scientists reveal key mechanism in worms that controls cell's response to stress

Scientists have revealed a key mechanism in worms that is involved in controlling the cell's response to stress, a study in eLife reports.

16 Jan 2019

Researchers discover how cancer cells avoid genetic meltdown

A team of scientists have shed light on how cancer cell populations avoid genetic meltdown, despite the rapid accumulation of harmful mutations.

15 Jan 2019

Researchers manipulate T cells to improve transplant success

Researchers have manipulated T cells in a way that prevents the rejection of transplanted organs, without affecting the immune system’s ability to fight microbial infection.

15 Jan 2019

Differences in geographic origin of genes may affect mitochondrial function

Differences in the geographic origin of genes may affect the function of human mitochondria--energy-generating organelles inside of cells--according to a new study.

14 Jan 2019

Scientists identify endogenous activator of sigma-1 receptors in human cells

Cells communicate through complex mechanisms that typically involve receptors and ligands that bind to them. Endogenous ligands, produced by the body, have been identified for the vast majority of cellular receptors, helping explain receptor existence and function. But in the case of sigma-1 receptors, which interact with a diverse array of psychoactive drugs, an endogenous ligand has remained elusive.

14 Jan 2019

Molecular hallmarks of tumor hypoxia across 19 cancer types discovered

Unlike healthy tissues, tumors thrive in low-oxygen environments, often acquiring the ability to resist treatment and spread to other sites in the body. Despite being a well-known cause of therapy resistance and metastasis, the impact of low oxygen, known as hypoxia, on tumor cells is poorly understood.

14 Jan 2019

UCR researchers uncover how plants sense temperature

When it gets hot outside, humans and animals have the luxury of seeking shelter in the shade or cool, air-conditioned buildings. But plants are stuck.

14 Jan 2019

Turning breast cancer cells into fat cells prevents the formation of metastases

An innovative combination therapy can force malignant breast cancer cells to turn into fat cells. This can be used to prevent the formation of metastases in mice, as researchers at the University of Basel's Department of Biomedicine recently reported in the journal Cancer Cell.

14 Jan 2019

Plan your Pittcon 2019 with the mobile app

The Pittcon marketing department is excited to announce the release of its official conference and exposition mobile app, Pittcon 2019.

From Pittcon 14 Jan 2019

Scientists discover mutational signatures of tumor hypoxia

Researchers have discovered mutational signatures of tumor hypoxia in 19 cancer types that could be used to identify patients who need higher treatment doses.

14 Jan 2019

New discovery casts doubt on plasma membrane models

Like planets, the body's cell surfaces look smooth from a distance but hilly closer up. An article published in Communications Biology describes implications, unknown to date, of the way data from cell surfaces are normally interpreted; i.e. as if they lacked topographic features.

14 Jan 2019

Conducting ChIP-Seq with Low Cell Numbers

An interview with Dr. Kathyrn Cunningham at SfN 2018, providing advice on carrying out Chromatin Immunoprecipitation Sequencing (ChIP-seq) with low cell numbers.

From Active Motif 14 Jan 2019

Novel microfluidic device for real-time detection of cholesterol in liver-on-chip cultures

In a paper to be published in the September/December 2019 issue of TECHNOLOGY, a team of researchers from the Department of Biomedical Engineering at Illinois Institute of Technology, Chicago has developed a novel microfluidic device for measuring in real-time the cholesterol secreted from liver tissue-chip containing human hepatocytes.

11 Jan 2019

CRISPR-Cas9 circular permutants can sense and respond to viral proteases

Using a technique called circular permutation, researchers at the University of California Berkeley have created a new suite of Cas9 variants called Cas9-CPs, which will simplify design of Cas9-fusion proteins for diverse applications beyond simple DNA cutting, such as base editing and epigenetic modifications.

11 Jan 2019