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Examining the effect of smoking, nicotine and vaping on COVID-19 severity

Researchers at the University of Oxford say they will be conducting the most extensive study to date linking primary and clinical data for the assessment of associations between smoking status and the severity of coronavirus disease 2019 (COVID-19).

9 Jun 2020

Researchers show how warmer weather might shape the spread of COVID-19

An international team of researchers led by McMaster University has found that while higher heat and humidity can slow the spread of COVID-19, longer hours of sunlight are associated with a higher incidence of the disease, in a sign that sunny days can tempt more people out even if this means a higher risk of infection.

9 Jun 2020

Convalescent plasma therapy for COVID-19 is safe and effective

A new systematic review available on medRxiv preprint server shows that using convalescent plasma in patients with coronavirus disease (COVID-19) is well-tolerated and may prompt the clearance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), as well as decrease disease severity; however, these effects are more pronounced in younger patients.

9 Jun 2020

New model can estimate regional disease burden and impact of vaccination

Researchers have developed a model that can estimate regional disease burden and the impact of vaccination, even in the absence of robust surveillance data, a study in eLife reveals.

9 Jun 2020

COVID-19 survivors could suffer long-term health effects

Patients recovering from COVID-19 could suffer significant long-term effects, according to research into the experiences of people hospitalized by previous coronavirus outbreaks.

9 Jun 2020

Study links COVID-19-based loneliness with elevated psychiatric symptoms in older adults

Although social distancing is crucial in thwarting the spread of COVID-19, isolation and the ensuing loneliness may be severely detrimental for older adults.

9 Jun 2020

Protease inhibition could help defeat SARS-CoV-2

As the COVID-19 pandemic caused by the coronavirus severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) continues to spread around the world, many researchers are studying epidemiological models to predict its propagation. As of yet, there are no effective vaccines that could counter the SARS- CoV-2 infection or drugs to treat COVID-19 disease

9 Jun 2020

A new strategy to combat influenza A and Zika virus

Leuven researchers have deployed synthetic amyloids to trigger protein misfolding as a strategy to combat the influenza A and Zika virus.

9 Jun 2020

Heart transplant recipients affected by COVID-19 face racial, gender disparities

Physician-scientists specializing in heart failure wanted to know: if their heart transplant patients contract COVID-19, would they have a different experience than the general public or others who are also immunosuppressed?

9 Jun 2020

Anti-RBD antibodies shown to neutralize active SARS-CoV-2

A new study published on the preprint server bioRxiv* in June 2020 reports the discovery of multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies in samples from healthy donors, collected before the pandemic. These antibodies are capable of inhibiting the binding of the spike protein of the virus to the angiotensin-converting enzyme 2 (ACE2) molecule and can neutralize active infection of cells in culture.

9 Jun 2020

Study: Coronavirus arrived in northern California through complex series of introductions

Distinct from virus transmission patterns identified elsewhere, analysis of SARS-CoV-2 genomes from a small number of California-based patients suggests the virus arrived in northern California through a complex series of introductions, not only from state to state but also from international travel.

9 Jun 2020

COVID-19 produces lung inflammation in non-human primate experiments

A new study published on the online preprint server bioRxiv in June 2020 reports the successful use of three primate species to model the infection, pathogenesis, and clinical features associated with COVID-19. The research provides useful and immediately available models to test new vaccines and treatments.

9 Jun 2020

Metabolic diseases alter ACE2 expression and increase COVID-19 severity

A new study published on the preprint server medRxiv in June 2020 reports that one mechanism for this variable severity is the differential expression of the ACE2 receptor in various metabolic conditions, thereby facilitating viral entry into the host cells.

9 Jun 2020

New study shows possible alternative pathway of SARS-CoV-2 infection in overactive bladder

A new study published on the preprint server bioRxiv*, in June 2020, reports that the condition of overactive bladder (OAB) could be associated with a different route of infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent for COVID-19 disease.

8 Jun 2020

Cremation numbers reveal possible suppression of true COVID-19 data in China

A potentially explosive new study published on the preprint server medRxiv in June 2020 suggests that the official Chinese statistics on COVID-19 cases or mortality are neither reliable nor credible. If true, such unreliable data during a crucial period of the pandemic in February and March 2020 could have seriously skewed the response and preparation of the rest of the world and altered the future course of the viral pneumonic illness.

8 Jun 2020

Scientists harness cancer immunotherapy tools to identify targets for COVID-19 vaccine

Cancer researchers at Children's Hospital of Philadelphia have harnessed tools used for the development of cancer immunotherapies and adapted them to identify regions of the SARS-CoV-2 virus to target with a vaccine, employing the same approach used to elicit an immune response against cancer cells to stimulate an immune response against the virus.

8 Jun 2020

Indirect viral infection of the kidneys by SARS-CoV-2-induced inflammatory reaction

SARS-CoV-2-associated acute kidney injury is not uncommon. Many hospitalized COVID-19 patients - as many as 80% of critically ill COVID-19 patients, according to a current study - develop acute kidney injury, but without requiring dialysis in most cases. Proteinuria and hematuria are present in about half the cases.

8 Jun 2020

Reflections and expectations: Are we handling COVID-19 in the right way?

COVID-19 Reflections: Severe lockdowns and Stay-at-Home orders have been hallmark of the national and global response to this Pandemic. They have been imposed with little precedent and scant evidence of their effectiveness as opposed to less restrictive social distancing measures.

8 Jun 2020

Human movement, poverty influence COVID-19 measures

A new study published on the preprint server medRxiv* in June 2020 explains the significant risk posed by poverty and the success of measures to counter COVID-19. The research sets out a model for more focused but productive interventions in high-risk groups that can reduce mortality rates significantly.

8 Jun 2020

Census of viral spike protein antigens could benefit development of SARS-CoV-2 therapeutics

A group of researchers has determined how different proteins associated with SARS-CoV-2 - the virus that causes COVID-19 - generate immune responses when given to rabbits as immunizations.

8 Jun 2020