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100 million covid shots in 100 days doesn’t get us back to normal

April 30 will mark the end of the first 100 days of President Joe Biden's tenure. That's a benchmark presidents often set for making good on high-priority campaign promises.

3 Feb 2021

Researchers survey repurposed drugs that inhibit SARS-CoV-2 replication in vitro

A new study by researchers at the University of Manchester, UK, reports on the compounds of interest that were identified as having potential for the treatment of COVID-19, from a library of almost 2,000 compounds from the APExBIO DiscoveryProbe library.

3 Feb 2021

Genomic study suggests SARS-CoV-2 clade 20C was imported into Japan from the US

A new study describes the outcome of such sequencing efforts in Japan as an important tool towards containing the spread of the infection.

3 Feb 2021

Long COVID-19 symptoms not associated with reduced cell-mediated immunity, finds study

A new preprint examines Long COVID-19, aiming to identify the underlying immunologic status in such patients.

3 Feb 2021

Oxysterol derivatives show powerful antiviral activity against SARS-CoV-2 in vitro

A new study describes the antiviral activity of oxysterols, or oxidized cholesterol derivatives, against SARS-CoV-2. These occur in nature, and are not only involved in lipid signaling pathways that modulate a host of processes within the body, including the immune response and lipid homeostasis.

3 Feb 2021

IONICON analyzers at the forefront of COVID-19 testing research

COVID-19 breath detection is studied around the globe using PTR-TOFMS.

From Ionicon Analytik Ges.m.b.H. 3 Feb 2021

Pregnant women had higher symptoms of depression, anxiety during COVID-19 pandemic

During the lockdown in the first wave of the COVID-19 pandemic in Spain, pregnant women had higher symptoms of depression and anxiety.

3 Feb 2021

Study finds higher pediatric SARS-CoV-2 burden than previously reported in the U.S.

In a new study, published on the pre-print server medRxiv*, researchers at Inova Children's Hospital and the George Mason University revealed that a much higher burden of SARS-CoV-2 infection was found in children than previously reported. This comes after the researchers assessed seropositivity among 1,038 children and adolescents.

3 Feb 2021

Researchers report trial results of rectal microbicides at HIV R4P Virtual Conference

Researchers seeking to develop on-demand and behaviorally congruent HIV prevention options for people who practice anal sex are reporting the results of three early phase clinical trials of rectal microbicides at this week's HIV Research for Prevention (HIV R4P) Virtual Conference.

3 Feb 2021

Novel strategy redirects generic antibodies to SARS-CoV-2 spike proteins

The SARS-CoV-2, the new coronavirus behind the current pandemic, infects humans by binding its surface-exposed spike proteins to ACE2 receptors exposed on the cell membranes.

3 Feb 2021

New risk stratification models could assist COVID-19 management

A novel study appearing as a preprint on the medRxiv server describes the performance of a new risk prediction model based on a wide range of patient variables for death and intensive care unit (ICU) admission.

3 Feb 2021

Airborne Infection Rate index predicts timing of second wave of pandemic

The "second wave" of the coronavirus pandemic has placed much blame on a lack of appropriate safety measures. However, due to the impacts of weather, research suggests two outbreaks per year during a pandemic are inevitable.

3 Feb 2021

Key variants help explain the differences between viruses that cause COVID-19 and SARS

An effort led by Lin Li, Ph.D., assistant professor of physics at The University of Texas at El Paso, in collaboration with students and faculty from Howard University, has identified key variants that help explain the differences between the viruses that cause COVID-19 and Severe Acute Respiratory Syndrome (SARS).

3 Feb 2021

One dose of VSV-vectored vaccine prevents SARS-CoV-2 replication in hamsters

A new preprint research paper posted to the bioRxiv server describes a viral vector vaccine candidate's efficacy to protect against SARS-CoV-2 replication in a hamster model.

3 Feb 2021

Study could help understand mechanisms of drug molecules to mitigate COVID-19 infection

As the scientific community continues researching the novel coronavirus, experts are developing new drugs and repurposing existing ones in hopes of identifying promising candidates for treating symptoms of COVID-19.

3 Feb 2021

J&J SARS-CoV-2 vaccine shows immunity in non-human primates 6 months after vaccination

A new preprint research paper released on the bioRxiv server discusses the findings from a model that assesses the association between the immunogenicity and protection conferred by a set of adenovirus- (Ad26)-vectored vaccines that express stabilized SARS-CoV-2 spike protein.

3 Feb 2021

Two-dose regimen of adenovirus-based vaccine offers 91.6% efficacy against COVID-19

An interim analysis of data from the phase 3 trial of the COVID-19 vaccine from Russia (Gam-COVID-Vac) suggests that a two-dose regimen of the adenovirus-based vaccine offers 91.6% efficacy against symptomatic COVID-19.

2 Feb 2021

Rapid SARS-CoV-2 antigen test improved with silver amplification

A new preprint posted to the medRxiv server describes the use of silver amplification technology to develop a sensitive, rapid antigen test for COVID-19.

2 Feb 2021

Prone positioning associated with lower mortality and intubation in COVID-19 patients

In the absence of specific antivirals to combat the pandemic, supportive care is paramount. In this context, a new preprint posted to the medRxiv server describes the observed efficacy of prone positioning to reduce mortality and the risk of intubation in COVID-19 patients with respiratory insufficiency.

2 Feb 2021

Single-dose vaccination effective for healthcare workers with prior SARS-CoV-2 infection

The findings reveal that healthcare workers previously infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) develop significantly higher antibody titers in response to a single dose of COVID-19 vaccine, as compared to healthcare workers without prior SARS-CoV-s infection. The study is currently available on the medRxiv* preprint server.

2 Feb 2021

Disease/Infection News

100 million covid shots in 100 days doesn’t get us back to normal

Researchers survey repurposed drugs that inhibit SARS-CoV-2 replication in vitro

Genomic study suggests SARS-CoV-2 clade 20C was imported into Japan from the US

Long COVID-19 symptoms not associated with reduced cell-mediated immunity, finds study

Oxysterol derivatives show powerful antiviral activity against SARS-CoV-2 in vitro

IONICON analyzers at the forefront of COVID-19 testing research

Pregnant women had higher symptoms of depression, anxiety during COVID-19 pandemic

Study finds higher pediatric SARS-CoV-2 burden than previously reported in the U.S.

Researchers report trial results of rectal microbicides at HIV R4P Virtual Conference

Novel strategy redirects generic antibodies to SARS-CoV-2 spike proteins

New risk stratification models could assist COVID-19 management

Airborne Infection Rate index predicts timing of second wave of pandemic

Key variants help explain the differences between viruses that cause COVID-19 and SARS

One dose of VSV-vectored vaccine prevents SARS-CoV-2 replication in hamsters

Study could help understand mechanisms of drug molecules to mitigate COVID-19 infection

J&J SARS-CoV-2 vaccine shows immunity in non-human primates 6 months after vaccination

Two-dose regimen of adenovirus-based vaccine offers 91.6% efficacy against COVID-19

Rapid SARS-CoV-2 antigen test improved with silver amplification

Prone positioning associated with lower mortality and intubation in COVID-19 patients

Single-dose vaccination effective for healthcare workers with prior SARS-CoV-2 infection

How the Vutara VXL simplifies single-molecule imaging

How cohesin mechanics and nanotracker tech are redefining DNA research

Todd Bauman and Chris Povich

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