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SNIFF study to examine safety, efficacy of nasal insulin for treating Alzheimer’s disease

Can insulin, the hormone used for nearly a century to treat diabetes, improve cognition, memory and daily function in people with mild cognitive impairment or mild dementia due to Alzheimer's disease? Rush University Medical Center is testing this innovative potential treatment as part of a new nationwide study.

25 Mar 2017

Study shows efficacy of biologics for mucosal healing in Crohn's disease and ulcerative colitis

Although anti-inflammatory treatments are quite effective at reducing symptoms in patients with Crohn's disease and ulcerative colitis, the mucosal lining of the intestine often remains ulcerated, and many patients still ultimately require surgery.

22 Mar 2017

First-in-human study shows positive results for new medicine that could reduce maternal deaths

The Monash University Institute of Pharmaceutical Sciences today announced positive results from a first-in-human study of a new, inhaled form of a medicine that could significantly reduce maternal deaths around the world.

21 Mar 2017

New gene-silencing drugs cut cholesterol levels by half in early research

The first in a new class of gene-silencing drugs, known as inclisiran, has been shown to halve cholesterol levels in patients at risk of cardiovascular disease.

21 Mar 2017

Supplemental use of vitamin E and selenium did not forestall dementia, study finds

Antioxidant supplements vitamin E and selenium - taken alone or in combination - did not prevent dementia in asymptomatic older men, according to a study published online by JAMA Neurology.

20 Mar 2017

Novel synthetic HDL-C injection shows no benefit on arterial plaques

Injection of a novel form of synthetic high-density lipoprotein cholesterol (HDL-C), or good cholesterol, into the arteries of patients who had recently had a heart attack did not reduce the volume of fatty deposits, or plaque, in the arteries, compared with placebo injections, according to research presented at the American College of Cardiology's 66th Annual Scientific Session.

20 Mar 2017

Study: Investigational Ebola vaccine regimen induced immune response that persisted for one year

A two-vaccine regimen intended to protect against Ebola virus disease induced an immune response that persisted for approximately one year in healthy adult volunteers, according to results from a Phase 1 clinical trial published in the March 14th issue of the Journal of the American Medical Association.

15 Mar 2017

New clinical study to test promising diabetes drug in people with MND

A diabetes drug could one day be used to treat neurodegenerative diseases like Motor Neurone Disease (MND), Alzheimer's and Parkinson's.

10 Mar 2017

Experts join forces to study affordable malaria drug for treating colorectal cancer

Experts from St George's University of London, and St George's Hospital have joined forces to investigate whether a common and cheap malaria drug can be used also against cancer.

7 Mar 2017

Clinical study seeks to examine new combination therapy for treating AML patients

A pair of drugs that may be a one-two punch needed to help combat acute myeloid leukemia (AML), an aggressive blood cancer that kills nearly three-fourths of patients within five years of diagnosis, is the focus of a new multi-center clinical trial that will enroll patients at three sites across the U.S.

7 Mar 2017

Study finds link between extended use MAO-B inhibitors and slow clinical decline in PD patients

There has long been interest in whether monoamine oxidase type B (MAO-B) inhibitors slow progression of Parkinson's disease (PD) and improve long-term outcomes.

6 Mar 2017

Study finds new drug treatment to be safe and well-tolerated in pediatric patients with anxiety

A pilot study of guanfacine, a controlled-release alpha2-agonist, in children and adolescents with general, separation-related, and social anxiety disorder showed the drug to be safe and well-tolerated and provided preliminary evidence of its potential effectiveness.

1 Mar 2017

New anti-cocaine monoclonal antibody moves forward towards clinical studies in humans

A University of Cincinnati researcher who has developed an immunotherapy to help reverse cocaine addiction that's been successful in animal models says he hopes to have it in clinical trials in human volunteers within a year.

28 Feb 2017

GUMC launches phase II clinical study to examine safety of cancer drug for Parkinson's disease

Georgetown University Medical Center today announces the launch of a phase II clinical trial to study the safety of the cancer drug nilotinib and its effects on clinical outcomes and biomarkers in people with Parkinson's disease.

27 Feb 2017

NIH launches new study to test experimental vaccine that targets mosquito-transmitted diseases

The National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, has launched a Phase 1 clinical trial to test an investigational vaccine intended to provide broad protection against a range of mosquito-transmitted diseases, such as Zika, malaria, West Nile fever and dengue fever, and to hinder the ability of mosquitoes to transmit such infections.

22 Feb 2017

Investigational malaria vaccine protects against multiple strains, study shows

An investigational malaria vaccine has protected a small number of healthy U.S. adults from infection with a malaria strain different from that contained in the vaccine, according to a study published today in the Proceedings of the National Academy of Sciences.

22 Feb 2017

Studies show benefits and risks of testosterone treatment in older men

It is commonly known that testosterone levels decrease as men age, but until last year, little was known about the effects of testosterone treatment in older men with low testosterone.

21 Feb 2017

Rapid patient recruitment and reduced trial costs: is LDS the answer?

LDS stands for Linked Database System, which essentially describes what it does. Our LDS technology uses multiple sources of information from hospitals, GPs and pharmacies. However in the future this information could also come from other health data sources e.g. your smartphone, Fitbit etc.

21 Feb 2017

Disappointing Merck drug news provides new blueprint for moving towards cure for Alzheimer's

The recent announcement that Merck is halting a Phase II/III study for a promising Alzheimer's treatment (verubecestat) was another setback in the continued and intensive effort to deliver an innovative therapy by 2020.

17 Feb 2017

Clinical trial to test potential new drug treatment for osteoarthritis

The University of Liverpool, in partnership with AKL Research and Development Ltd, is to lead on a clinical trial to test a potential new drug treatment for osteoarthritis.

16 Feb 2017