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Sanford clinical study exploring immunotherapy drug to treat patients with advanced esophageal cancer

A clinical trial at Sanford Health is studying if an immunotherapy drug developed by Merck might be able to treat certain patients with advanced esophageal cancer. The Merck Keynote 181 trial is now open at Sanford.

31 Jan 2017

First-time drug trials launched on basis of flimsy, under-scrutinized evidence, say McGill researchers

Standards for authorizing first-time trials of drugs in humans are lax, and should be strengthened in several ways, McGill University researchers argue in a paper published today in Nature.

30 Jan 2017

ALCMI and Scancell collaborate to advance cancer vaccine clinical trials in NSCLC patients

The Addario Lung Cancer Medical Institute, the Bonnie J. Addario Lung Cancer Foundation and Scancell Holdings PLC today announce a collaboration to evaluate the use of Scancell's second innovative cancer vaccine, SCIB2, from its ImmunoBody platform to treat non-small cell lung cancer.

30 Jan 2017

New immunotherapy active against mucosal melanoma and improves survival for bladder cancer patients

Clinical trials of a new immunotherapy, pembrolizumab, have shown that it prolongs life significantly for patients with bladder cancer and is active against a rare sub-type of melanoma, called mucosal melanoma.

30 Jan 2017

Northwestern Medicine investigators to lead clinical trial for people with rare cancers

A novel national trial for people with no established alternative to treat their rare cancers is being co-led by Northwestern Medicine investigators, who helped conceive of and develop the project.

19 Jan 2017

New drug delivery system by Renishaw hopes to aid Parkinson’s treatment

Renishaw’s novel drug delivery system, to be used in partnership with Herantis Pharma Plc’s drug candidate CDNF for the treatment of Parkinson’s disease, is about to enter phase 1-2 clinical trials. The study will be supported by a €6 million grant from Horizon 2020, the European Union’s Framework Programme for Research and Innovation.

From Renishaw plc - Spectroscopy 12 Jan 2017

Ardelyx initiates two clinical trials to evaluate new treatment for hyperkalemia

Ardelyx, Inc., a clinical-stage company focused on enhancing the treatment of patients with gastrointestinal and cardiorenal diseases, today announced the initiation of a Phase 3 clinical trial and an onset-of-action clinical trial evaluating RDX7675 in patients with hyperkalemia, a potentially life-threatening condition common in patients with cardiorenal disease.

3 Jan 2017

Phase I study of selumetinib drug shows partial response in pediatric neural tumors

In an early-phase clinical trial of a new oral drug, selumetinib, children with the common genetic disorder neurofibromatosis type 1 (NF1) and plexiform neurofibromas, tumors of the peripheral nerves, tolerated selumetinib and, in most cases, responded to it with tumor shrinkage.

29 Dec 2016

FDA grants permission to assess safety of investigational drug for Alzheimer's disease in humans

Vanderbilt University scientists have received notification from the U.S. Food and Drug Administration that testing in humans may proceed for an investigational new drug for Alzheimer's disease after more than 10 years of research by scientists at Vanderbilt University and Vanderbilt University Medical Center.

28 Dec 2016

New study shows efficacy of Ebola vaccine in offering protection against disease

An experimental Ebola vaccine was highly protective against the deadly virus in a major trial in Guinea, according to a new study that included researchers from the University of Maryland School of Medicine.

26 Dec 2016

UF researchers play integral role in Ebola vaccine trial

An international group of researchers associated with the World Health Organization has published its final report on the Ebola vaccine trial in Guinea, finding that the vaccine is a safe and effective way to prevent Ebola infection.

26 Dec 2016

Experimental Ebola vaccine offers high protection against deadly virus, reveals major trial

An experimental Ebola vaccine was highly protective against the deadly virus in a major trial in Guinea, according to results published today in The Lancet. The vaccine is the first to prevent infection from one of the most lethal known pathogens, and the findings add weight to early trial results published last year.

23 Dec 2016

First large-scale clinical study of long-acting injectable HIV drug begins

The first large-scale clinical trial of a long-acting injectable drug for HIV prevention began today.

21 Dec 2016

Landmark clinical trial to test third investigational drug for Alzheimer's disease

An international team led by Washington University School of Medicine in St. Louis has selected a third investigational drug to be tested in a worldwide clinical trial - already underway - aimed at finding treatments to prevent Alzheimer's disease.

20 Dec 2016

NIH-supported first HIV vaccine efficacy study begins in South Africa

The first HIV vaccine efficacy study to launch anywhere in seven years is now testing whether an experimental vaccine regimen safely prevents HIV infection among South African adults.

28 Nov 2016

Drug combination therapy delays progression of advanced breast cancer without side effects, study shows

Building on earlier clinical trials, UCLA researchers have confirmed that the "breakthrough" drug palbociclib when used in combination with the traditional hormonal therapy letrozole delays progression of advanced breast cancer significantly and without the harsh side effects seen in some women prescribed letrozole alone.

18 Nov 2016

NYU Langone-led study to examine longer-term use of suppressive antiviral medication to reduce shingles

NYU Langone Medical Center will lead a five-year, 60-center clinical trial to evaluate new treatment protocols for herpes zoster ophthalmicus (HZO), a form of shingles that can seriously and permanently affect the eye.

17 Nov 2016

Allergan, Amgen submit BLA for ABP 215 oncology biosimilar medicine to FDA

Amgen and Allergan plc. today announced the submission of a Biologics License Application (BLA) to the U.S. Food and Drug Administration (FDA) for ABP 215, a biosimilar candidate to Avastin (bevacizumab).

16 Nov 2016

Clinical study to test safety and ability of investigational Zika vaccine candidate begins

The first of five early stage clinical trials to test the safety and ability of an investigational Zika vaccine candidate called the Zika Purified Inactivated Virus (ZPIV) vaccine to generate an immune system response has begun at the Walter Reed Army Institute of Research Clinical Trial Center in Silver Spring, Maryland.

7 Nov 2016

Sanford opens new immunotherapy study on colorectal cancer

Sanford Health has opened another clinical trial exploring the power of the body's immune system to fight cancer.

21 Oct 2016

Drug Trial News

Sanford clinical study exploring immunotherapy drug to treat patients with advanced esophageal cancer

First-time drug trials launched on basis of flimsy, under-scrutinized evidence, say McGill researchers

ALCMI and Scancell collaborate to advance cancer vaccine clinical trials in NSCLC patients

New immunotherapy active against mucosal melanoma and improves survival for bladder cancer patients

Northwestern Medicine investigators to lead clinical trial for people with rare cancers

New drug delivery system by Renishaw hopes to aid Parkinson’s treatment

Ardelyx initiates two clinical trials to evaluate new treatment for hyperkalemia

Phase I study of selumetinib drug shows partial response in pediatric neural tumors

FDA grants permission to assess safety of investigational drug for Alzheimer's disease in humans

New study shows efficacy of Ebola vaccine in offering protection against disease

UF researchers play integral role in Ebola vaccine trial

Experimental Ebola vaccine offers high protection against deadly virus, reveals major trial

First large-scale clinical study of long-acting injectable HIV drug begins

Landmark clinical trial to test third investigational drug for Alzheimer's disease

NIH-supported first HIV vaccine efficacy study begins in South Africa

Drug combination therapy delays progression of advanced breast cancer without side effects, study shows

NYU Langone-led study to examine longer-term use of suppressive antiviral medication to reduce shingles

Allergan, Amgen submit BLA for ABP 215 oncology biosimilar medicine to FDA

Clinical study to test safety and ability of investigational Zika vaccine candidate begins

Sanford opens new immunotherapy study on colorectal cancer

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