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New combination therapy shows promising results in some patients with advanced head and neck cancer

A new combination drug treatment showed promising results in patients with pan-refractory, recurrent/metastatic head and neck cancer, according to a study published today in the Journal of Clinical Oncology.

28 Mar 2023

Chemotherapy plus immunotherapy improves outcomes in patients with advanced endometrial cancer

Endometrial cancer, which makes up about 90% of uterine cancers, will be diagnosed in more than 65,000 people in the United States this year.

28 Mar 2023

Combination treatment for advanced endometrial cancer significantly reduces disease growth

In a study published in the March 27, 2023, online edition of the New England Journal of Medicine, researchers at the University of California San Diego School of Medicine and Moores Cancer Center at UC San Diego Health found the combination of immunotherapy (pembrolizumab) and chemotherapy in patients with advanced or recurrent/advanced endometrial cancer resulted in a significant reduction in disease growth when compared with chemotherapy alone.

27 Mar 2023

Candidate hepatitis C mRNA vaccine induces protective immunity in animal model

In a recent study published in the npj vaccines journal, researchers assessed the immune protection elicited by messenger ribonucleic acid (mRNA) vaccines delivering Hepatitis C virus (HCV) E1 and modified E2.

23 Mar 2023

Tetravalent COVID vaccine provides broad antibody responses against SARS-CoV-2 variants in animal model

In a recent study posted to the bioRxiv* preprint server, researchers in Italy and the United States evaluated the efficacy and immunogenicity of an adjuvanted tetravalent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein subunit 1 (S1) COVID-19 vaccine.

21 Mar 2023

MHRA to introduce a series of new measures for streamlining clinical trial approvals

A series of new measures will be introduced by the Medicines and Healthcare products Regulatory Agency (MHRA) with support from partners to make it faster and easier to gain approval and to run clinical trials in the UK.

21 Mar 2023

Drug combination may reduce the risk of prostate cancer progression, death

TALAPRO-2, a study led by Neeraj Agarwal, MD, FASCO, demonstrated that using TALZENNA, in combination with XTANDI, may reduce the risk of disease progression or death by 37%.

17 Mar 2023

Trial shows encouraging results for neoadjuvant dual immunotherapy and chemotherapy in patients with resectable NSCLC

In a Phase II trial led by researchers from The University of Texas MD Anderson Cancer Center, adding ipilimumab to a neoadjuvant, or pre-surgical, combination of nivolumab plus platinum-based chemotherapy, resulted in a major pathologic response (MPR) in half of all treated patients with early-stage, resectable non-small cell lung cancer (NSCLC).

16 Mar 2023

Study demonstrates long-term safety and clinical benefit of combination therapy for cystic fibrosis

Patients with cystic fibrosis (CF) face difficulty breathing and a decline in lung function and are at risk of early death. CF is an inherited condition that results in thick mucus build-up, persistent infection and inflammation in the lungs.

15 Mar 2023

Clinical trial shows promising results for oral psoriasis treatment

A company launched from The University of Queensland's Institute for Molecular Bioscience (IMB) has passed an important milestone in developing an oral treatment for the common skin disease psoriasis.

15 Mar 2023

Injectable peptide used for type 2 diabetes shows potential for treating 'blinding' IIH headaches

Patients with 'blinding' headaches known as Idiopathic Intercranial Hypertension could be treated with an injectable peptide used for type 2 diabetes, a new trial has found.

13 Mar 2023

New antimalarial prevents malaria more effectively than current treatments but does not improve birth outcomes

A large LSTM-led trial confirms new antimalarial, dihydroartemisinin-piperaquine, is more effective at preventing malaria than current WHO recommended treatment but does not improve adverse birth outcomes.

10 Mar 2023

Examining the effect of hormone replacement therapy on postmenopausal heart disease and cognitive decline

Many are aware of the short-term symptoms often associated with menopause, such as hot flashes, which are attributed to changes in reproductive hormones.

9 Mar 2023

Study explores solutions for advancing health equity through diversifying clinical trials

Despite racial and ethnic minority groups making up nearly half of the United States population, underrepresentation in clinical trials remains a critical challenge.

9 Mar 2023

Nirogacestat shows promising results in patients with desmoid tumors

When Dana Avellino, now 36, first noticed a lump near her groin in the summer of 2018, she thought it was related her recent cesarean section. Her younger daughter was only 2 months old at the time.

9 Mar 2023

Pilot trial tests nasal monoclonal antibody treatment for COVID-19

A pilot trial by investigators from Brigham and Women's Hospital, a founding member of the Mass General Brigham healthcare system, tested the nasal administration of the drug Foralumab, an anti-CD3 monoclonal antibody.

8 Mar 2023

Yale Cancer Center receives funding to increase access to early phase clinical trials

Yale Cancer Center is pleased to announce collaborative funding to support and increase access to early phase clinical trials for patients at community sites for cancer care in Connecticut.

6 Mar 2023

LDL cholesterol levels reduced by oral PCSK9 inhibitor in phase 2 trial

MK-0616, an experimental oral proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor, met its primary endpoint and substantially reduced levels of low-density lipoprotein (LDL) cholesterol in people with high cholesterol and/or heart disease related to clogged arteries, in a study being presented at the American College of Cardiology's Annual Scientific Session Together With the World Congress of Cardiology.

6 Mar 2023

Addition of sotatercept to existing therapy shows promise for the treatment of pulmonary arterial hypertension

Patients with pulmonary arterial hypertension (PAH), a severe, progressive condition that affects the heart and lungs, who were treated with the novel first-in-class medication sotatercept on top of existing therapy experienced significant improvements in walking distance via a six-minute walking test—the study's primary endpoint and a validated surrogate for functional improvement and reduced symptom burden.

6 Mar 2023

Clinical trial shows safety and immunogenicity of temperature-stable experimental TB vaccine

A clinical trial testing a freeze-dried, temperature-stable experimental tuberculosis (TB) vaccine in healthy adults found that it was safe and stimulated both antibodies and responses from the cellular arm of the immune system.

6 Mar 2023

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Drug Trial News

New combination therapy shows promising results in some patients with advanced head and neck cancer

Chemotherapy plus immunotherapy improves outcomes in patients with advanced endometrial cancer

Combination treatment for advanced endometrial cancer significantly reduces disease growth

Candidate hepatitis C mRNA vaccine induces protective immunity in animal model

Tetravalent COVID vaccine provides broad antibody responses against SARS-CoV-2 variants in animal model

MHRA to introduce a series of new measures for streamlining clinical trial approvals

Drug combination may reduce the risk of prostate cancer progression, death

Trial shows encouraging results for neoadjuvant dual immunotherapy and chemotherapy in patients with resectable NSCLC

Study demonstrates long-term safety and clinical benefit of combination therapy for cystic fibrosis

Clinical trial shows promising results for oral psoriasis treatment

Injectable peptide used for type 2 diabetes shows potential for treating 'blinding' IIH headaches

New antimalarial prevents malaria more effectively than current treatments but does not improve birth outcomes

Examining the effect of hormone replacement therapy on postmenopausal heart disease and cognitive decline

Study explores solutions for advancing health equity through diversifying clinical trials

Nirogacestat shows promising results in patients with desmoid tumors

Pilot trial tests nasal monoclonal antibody treatment for COVID-19

Yale Cancer Center receives funding to increase access to early phase clinical trials

LDL cholesterol levels reduced by oral PCSK9 inhibitor in phase 2 trial

Addition of sotatercept to existing therapy shows promise for the treatment of pulmonary arterial hypertension

Clinical trial shows safety and immunogenicity of temperature-stable experimental TB vaccine

Real-time Raman monitoring for pharmaceutical hot melt extrusion

Synthetic Psychedelics: A Growing Public Health Concern

How the Vutara VXL simplifies single-molecule imaging

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