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Augmenting an antidepressant with aripiprazole may help some older adults with treatment-resistant depression

For older adults with clinical depression that has not responded to standard treatments, adding the drug aripiprazole (brand name Abilify) to an antidepressant they're already taking is more effective than switching from one antidepressant to another, according to a new multicenter study led by Washington University School of Medicine in St. Louis.

3 Mar 2023

Clinical study reveals new use for high blood pressure drug in pediatric patients

A clinical study conducted by Indiana University School of Medicine researchers revealed that oral verapamil, a readily available and commonly used drug to treat high blood pressure and heart conditions, can also improve the pancreas' insulin secretion in children with newly-diagnosed type 1 diabetes (T1D).

1 Mar 2023

Study shows the beneficial effect of verapamil in children with newly-diagnosed type 1 diabetes

Published in JAMA, a University of Minnesota led study shows that verapamil, a drug commonly used to treat high blood pressure and heart conditions, can have a beneficial effect on the pancreas in children with newly-diagnosed type 1 diabetes (T1D).

24 Feb 2023

Disabilities in people with heart disease underreported in clinical trials

Disabilities were underreported in clinical trial data and commonly used as a basis for exclusion from trial participation in an analysis of 80 recent trials involving cardiovascular outcomes, according to a study being presented at the American College of Cardiology's Annual Scientific Session Together With the World Congress of Cardiology.

23 Feb 2023

Two newer simplified HIV treatment options found to be at least as effective as the standard of care

Two newer simplified treatment options are at least as effective as current approaches, according to the results of a world-first international clinical trial into second-line HIV therapy led by the Kirby Institute at UNSW Sydney and presented today at the Conference on Retroviruses and Opportunistic Infections in Seattle.

23 Feb 2023

First phase I trial of intravenous mistletoe extract to treat advanced cancer

Mistletoe extract has been widely used to support cancer therapy and improve quality of life, but there has been a lack of clinical trials and data to support its use.

22 Feb 2023

First clinical trial of GABA/GAD focused exclusively on children with recent onset Type 1 diabetes

For the first time, humans with newly diagnosed Type 1 diabetes, or T1D, have received two treatments called GABA and GAD that have shown promise in animal studies and in isolated human pancreas islets. This investigator-initiated clinical trial, published in Nature Communications, focused exclusively on children with recent onset T1D.

22 Feb 2023

Use of dapivirine vaginal ring during third trimester of pregnancy poses no safety concerns

A vaginal ring containing the antiretroviral drug dapivirine posed no safety concerns when used in the third trimester of pregnancy, according to results to date from the first study of the dapivirine ring during pregnancy and one of only a few studies of an HIV prevention product in pregnant cisgender women.

20 Feb 2023

Doxycycline taken after sex does not prevent bacterial STIs among cisgender women

Researchers from the University of Washington (UW), Kenya Medical Research Institute (KEMRI), and Hennepin Healthcare Research Institute (HHRI) announced results at CROI from a clinical trial demonstrating that doxycycline taken after sex does not prevent bacterial sexually transmitted infections (STIs) – chlamydia or gonorrhea – among cisgender women.

20 Feb 2023

Lord James O'Shaughnessy appointed to conduct an independent review into UK clinical trials

The government has appointed Lord James O'Shaughnessy, Senior Partner at consultancy firm Newmarket Strategy, Board Member of Health Data Research UK (HDR UK), and former Health Minister, to conduct an independent review into the UK commercial clinical trials landscape.

20 Feb 2023

Are SGLT2 inhibitors the next blockbuster drug?

Recent clinical trials investigating the therapeutic potency of sodium-glucose cotransporter 2 inhibitors (SGLT2i) have highlighted that this drug is highly effective in treating patients with cardiovascular and renal diseases.

19 Feb 2023

A new trial to assess if butyrate can prevent colon cancer

Researchers discuss a new clinical trial that will determine the efficacy of butyrate administration in preventing colon cancer.

16 Feb 2023

Nirmatrelvir-ritonavir therapy effective against Omicron BA.4/BA.5

Researchers examine non-hospitalized adult patients with COVID-19 treated with nirmatrelvir-ritonavir.

15 Feb 2023

Neoadjuvant nivolumab treatment improves survival rates in NSCLC patients

Patients with resectable non-small cell lung cancer (NSCLC) who were treated with neoadjuvant nivolumab had improved five-year recurrence-free and overall survival rates compared with historical outcomes.

15 Feb 2023

NIH initiates a clinical trial evaluating an investigational antiviral for treatment of COVID-19

The National Institutes of Health has initiated a multi-site clinical trial evaluating an investigational antiviral for the treatment of COVID-19.

15 Feb 2023

Neuroprotectant linked to reduced death and disability among stroke patients

The neuroprotectant ApTOLL, a medication that may shield the brain from tissue damage, was linked to reduced death and disability among people being treated for stroke when used with standard treatments to restore blood flow, according to preliminary late-breaking science presented today at the American Stroke Association's International Stroke Conference 2023.

13 Feb 2023

Two cardiovascular drugs may help improve outcomes for patients who experienced small vessel stroke

A study of two widely used cardiovascular medications — cilostazol and isosorbide mononitrate — in more than 350 patients confirmed the two medications were well-tolerated and safe for people who have experienced a stroke in a small blood vessel deep in the brain.

13 Feb 2023

Pegylated interferon lambda shows good efficacy against COVID-19

In a recent study published in The New England Journal of Medicine, researchers used the TOGETHER platform trial protocol to perform a phase III randomized controlled trial (RCT) to evaluate the effectiveness of pegylated interferon (IFN) lambda (λ) therapy in outpatients with coronavirus disease 2019 (COVID-19) in Canada and Brazil.

9 Feb 2023

Novel COVID-19 protein component vaccine elicits durable immune response in rodents

Researchers describe a novel SARS-CoV-2 spike protein component vaccine called MT-001.

9 Feb 2023

Four teams supported by SU2C focus on increasing diversity in early phase cancer clinical trials

Stand Up To Cancer today announced four teams focused on increasing diversity in early phase cancer clinical trials.

8 Feb 2023

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Drug Trial News

Augmenting an antidepressant with aripiprazole may help some older adults with treatment-resistant depression

Clinical study reveals new use for high blood pressure drug in pediatric patients

Study shows the beneficial effect of verapamil in children with newly-diagnosed type 1 diabetes

Disabilities in people with heart disease underreported in clinical trials

Two newer simplified HIV treatment options found to be at least as effective as the standard of care

First phase I trial of intravenous mistletoe extract to treat advanced cancer

First clinical trial of GABA/GAD focused exclusively on children with recent onset Type 1 diabetes

Use of dapivirine vaginal ring during third trimester of pregnancy poses no safety concerns

Doxycycline taken after sex does not prevent bacterial STIs among cisgender women

Lord James O'Shaughnessy appointed to conduct an independent review into UK clinical trials

Are SGLT2 inhibitors the next blockbuster drug?

A new trial to assess if butyrate can prevent colon cancer

Nirmatrelvir-ritonavir therapy effective against Omicron BA.4/BA.5

Neoadjuvant nivolumab treatment improves survival rates in NSCLC patients

NIH initiates a clinical trial evaluating an investigational antiviral for treatment of COVID-19

Neuroprotectant linked to reduced death and disability among stroke patients

Two cardiovascular drugs may help improve outcomes for patients who experienced small vessel stroke

Pegylated interferon lambda shows good efficacy against COVID-19

Novel COVID-19 protein component vaccine elicits durable immune response in rodents

Four teams supported by SU2C focus on increasing diversity in early phase cancer clinical trials

Real-time Raman monitoring for pharmaceutical hot melt extrusion

Synthetic Psychedelics: A Growing Public Health Concern

How the Vutara VXL simplifies single-molecule imaging

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