Genomics

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New technique can label diverse molecules in a single tissue sample

A new technique can label diverse molecules and amplify the signal to help researchers spot those that are especially rare. Called SABER (signal amplification by exchange reaction), Peng Yin's lab at Harvard's Wyss Institute first introduced this method last year and since have found ways to apply it to proteins, DNA and RNA.

16 Feb 2020

Novel technique to study gene splicing reveals new insights into the process

Genes are like instructions, but with options for building more than one thing. Daniel Larson, senior investigator at the National Cancer Institute, studies this gene "splicing" process, which happens in normal cells and goes awry in blood cancers like leukemia.

16 Feb 2020

New biological tool can detect and debug faulty genetic circuits

Every cell in our body has a computer-like control system that sends biological signals through thousands of circuits to monitor the cell's needs and regulate its responses.

16 Feb 2020

Research reveals new pathogenic mechanism for influenza NS1 protein

Influenza is a deadly virus, with about 290,000 to 650,000 deaths worldwide each year. When pandemics hit, the toll can soar: The Spanish flu of 1918 caused 40 million to 50 million deaths, the Asian flu of 1957 caused 2 million deaths, and the Hong Kong flu of 1968 caused 1 million deaths.

16 Feb 2020

Researchers identify key modifier in large genetic deletion linked to neurodevelopmental disorders

Neurodevelopmental disorders, including schizophrenia and autism, likely result from complex interactions that modify the effects of individual genes.

16 Feb 2020

UIC researchers discover unique organ-specific signatures for endothelial cells

Researchers from the University of Illinois at Chicago have discovered that endothelial cells -; those that create the inner lining of blood vessels -; have unique genetic signatures based on their location in the body.

14 Feb 2020

Molecular study defines the contributions of key genes, proteins to endometrial cancer

The most comprehensive molecular study of endometrial cancer to date has further defined the contributions of key genes and proteins to the disease, say its authors.

13 Feb 2020

New method to measure mutations in father's sperm may reveal ASD risk in future children

While the causes of autism spectrum disorder are not fully understood, researchers believe both genetics and environment play a role.

13 Feb 2020

Marine bacteria genes can help track environmental changes caused by humans

The gene expression of marine bacteria can be a valuable sensor for discovering environmental changes caused by humans. Furthermore, bacteria help to clean our oceans and hopefully they could be used to purify drinking water from harmful environmental toxins in the future.

13 Feb 2020

Vapers exhibit similar chemical changes in their genome as smokers

Biologically important changes in DNA seen in smokers are also being found in people who vape, according to a new study published in the journal Epigenetics.

12 Feb 2020

DNA misfolding linked to heightened risk for Type 1 diabetes

It's known that genetics, or an inherited genome, is a major determinant of one's risk for autoimmune diseases, like Type 1 diabetes. In human cells, a person's genome--about six feet of DNA--is compressed into the micrometer space of the nucleus via a three-dimensional folding process.

11 Feb 2020

Pioneering project on genomic edition through CRISPR/Cas9 to study early embryonic development

Characterization studies of early embryonic development are limited, mainly due to the lack of samples and the obvious legal and ethical limitations.

11 Feb 2020

New mechanism for repair of chromosomal breaks

Chromosomal breaks are the most harmful damage for cells. If they are not repaired, they block the duplication and segregation of chromosomes, stop the growth cycle and cause cell death. These breaks appear frequently in tumor cells and are produced spontaneously during the replication of genetic material.

10 Feb 2020

Bayer and Meiogenix join forces to advance agricultural research and development

Bayer and Meiogenix, a biotech company focused on next-generation breeding technologies, announced today a collaboration to advance agricultural research and development by accelerating the development of Meiogenix's proprietary technologies related to plant breeding and genome editing applications.

From Bayer AG 10 Feb 2020

Scientists come together to better understand patented innovations available for gene therapy

The global gene therapy market is expected to reach $13 billion by 2024 as new treatment options target cancers and other diseases.

9 Feb 2020

Biological toolkit will help researchers design new functions in mammalian cells

A new synthetic biology toolkit developed at Northwestern University will help researchers design mammalian cells with new functionalities.

9 Feb 2020

Rhizosphere microbiome can systemically shape and control root exudation

Roots are plant organs, that typically absorb water and minerals from soil. It is lesser known that roots also secrete metabolites, so-called root exudates, which impact the properties of soil directly around the root.

9 Feb 2020

Princeton's Bonnie Bassler awarded the 2020 Gruber Genetics Prize

The 2020 Gruber Genetics Prize is being awarded to geneticist Bonnie Bassler, Ph.D. of Princeton University and the Howard Hughes Medical Institute, for her groundbreaking work on how bacteria "talk" to each other using molecular "languages."

9 Feb 2020

Genomic sequencing technique helps understand gut microbiota one cell at a time

A population of microorganisms living in our intestine, known as the gut microbiota, plays a crucial role in controlling our metabolism and reducing the risk of conditions such as obesity and diabetes.

9 Feb 2020

Research provides new insights into molecular basis of X-chromosome inactivation

Researchers at the European Molecular Biology Laboratory in Heidelberg and Institut Curie in Paris have shown that the protein SPEN plays a crucial role in the process of X-chromosome inactivation, whereby female mammalian embryos silence gene expression on one of their two X chromosomes.

7 Feb 2020

Genomics

New technique can label diverse molecules in a single tissue sample

Novel technique to study gene splicing reveals new insights into the process

New biological tool can detect and debug faulty genetic circuits

Research reveals new pathogenic mechanism for influenza NS1 protein

Researchers identify key modifier in large genetic deletion linked to neurodevelopmental disorders

UIC researchers discover unique organ-specific signatures for endothelial cells

Molecular study defines the contributions of key genes, proteins to endometrial cancer

New method to measure mutations in father's sperm may reveal ASD risk in future children

Marine bacteria genes can help track environmental changes caused by humans

Vapers exhibit similar chemical changes in their genome as smokers

DNA misfolding linked to heightened risk for Type 1 diabetes

Pioneering project on genomic edition through CRISPR/Cas9 to study early embryonic development

New mechanism for repair of chromosomal breaks

Bayer and Meiogenix join forces to advance agricultural research and development

Scientists come together to better understand patented innovations available for gene therapy

Biological toolkit will help researchers design new functions in mammalian cells

Rhizosphere microbiome can systemically shape and control root exudation

Princeton's Bonnie Bassler awarded the 2020 Gruber Genetics Prize

Genomic sequencing technique helps understand gut microbiota one cell at a time

Research provides new insights into molecular basis of X-chromosome inactivation

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