Genomics

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Optical genome mapping could change the existing workflow within cytogenetic laboratories

Dutch-French research shows that Optical Genome Mapping (OGM) detects abnormalities in chromosomes and DNA very quickly, effectively and accurately. Sometimes even better than all existing techniques together, as they describe in two proof-of-concept studies published in the American Journal of Human Genetics.

8 Jul 2021

Uncovering cellular mechanism related to gene silencing therapies

Gene silencing therapies are used to interfere with, or "silence", the expression of genes that are associated with disorders. Now, a team at TMDU has uncovered some of the cellular mechanisms by which the silencing therapies act in cells.

7 Jul 2021

NYUAD researchers unlock an epigenetic code that allows liver regeneration

NYU Abu Dhabi researchers uncovered a code that sets the genome of the liver to account for the remarkable ability for this organ to regenerate.

6 Jul 2021

Comprehensive genetic study provides new insights on cleft lip and palate

Cleft lip and palate is one of the most common congenital malformations. Its causes are mainly genetic. However, it is still largely unknown exactly which genes are affected.

6 Jul 2021

Brain cells snap DNA strands in numerous locations to make memories

The urgency to remember a dangerous experience requires the brain to make a series of potentially dangerous moves: Neurons and other brain cells snap open their DNA in numerous locations--more than previously realized, according to a new study--to provide quick access to genetic instructions for the mechanisms of memory storage.

6 Jul 2021

Castration of male sheep slows DNA aging

Most of us are familiar with the fact that women live longer than men. But fellas, if we told you there was one thing that could be done to increase your lifespan, would you do it?

6 Jul 2021

New genetic biobank could hold the key to preventing SIDS

A state-of-the-art genetic biobank could hold the key to preventing Sudden Infant Death Syndrome (SIDS), potentially saving the lives of hundreds of babies who die from the devastating condition each year.

5 Jul 2021

Genetic variants in a neuro-associated gene cause neurodevelopmental disorder, finds study

Mayo Clinic researchers have discovered that genetic variants in a neuro-associated gene called SPTBN1 are responsible for causing a neurodevelopmental disorder. The study, published in Nature Genetics, is a first step in finding a potential therapeutic strategy for this disorder, and it increases the number of genes known to be associated with conditions that affect how the brain functions.

2 Jul 2021

Scientists discover genetic basis and molecular mechanisms of new neurodevelopmental syndrome

Scientists at the University of North Carolina at Chapel Hill School of Medicine and colleagues have demonstrated that variants in the SPTBN1 gene can alter neuronal architecture, dramatically affecting their function and leading to a rare, newly defined neurodevelopmental syndrome in children.

1 Jul 2021

Study offers clues for earlier diagnosis of folate deficiency

As many expectant mothers know, getting enough folate is key to avoiding neural tube defects in the baby during pregnancy. But for the individuals who carry certain genetic variants, dealing with folate deficiency can be a life-long struggle which can lead to serious neurological and heart problems and even death.

1 Jul 2021

Researchers discover genetic markers that drive the timing of first sex and birth

An Oxford-led team, working with Cambridge and international scholars, has discovered hundreds of genetic markers driving two of life's most momentous milestones - the age at which people first have sex and become parents.

1 Jul 2021

Reduced function of key gene may affect communication between motor neurons and muscles in ALS

Amyotrophic lateral sclerosis, or ALS, attacks nerve cells known as motor neurons in the brain and spinal cord, gradually leading to paralysis.

30 Jun 2021

New method to transport RNA-based drugs to subpopulation of immune cells

Tel Aviv University's groundbreaking technology may revolutionize the treatment of cancer and a wide range of diseases and medical conditions. In the framework of this study, the researchers were able to create a new method of transporting RNA-based drugs to a subpopulation of immune cells involved in the inflammation process, and target the disease-inflamed cell without causing damage to other cells.

30 Jun 2021

DNA sequencing from water and leech bloodmeals helps identify novel mammalian viruses

In a new scientific investigation headed by the German Leibniz Institute for Zoo and Wildlife Research, water from African and Mongolian waterholes as well as bloodmeals from Southeast Asian leeches were assessed for the ability to retrieve mammalian viruses without the need to find and catch the mammals.

28 Jun 2021

RAMBO can cut indexing times for huge DNA databases

Rice University computer scientists are sending RAMBO to rescue genomic researchers who sometimes wait days or weeks for search results from enormous DNA databases.

28 Jun 2021

New analysis links distinct patterns of genetic mutations with OCD

In the first analysis of its kind, researchers at Columbia University Vagelos College of Physicians and Surgeons and several other institutions have linked distinct patterns of genetic mutations with obsessive-compulsive disorder (OCD) in humans.

28 Jun 2021

First CRISPR-Cas9-based gene drive cuts and copies genetic elements in Arabidopsis plants

With a goal of breeding resilient crops that are better able to withstand drought and disease, University of California San Diego scientists have developed the first CRISPR-Cas9-based gene drive in plants.

25 Jun 2021

TET enzymes play key role in keeping immune cells on a healthy track

Researchers at La Jolla Institute for Immunology (LJI) have shed light on a process in immune cells that may explain why some people develop cardiovascular diseases.

25 Jun 2021

New book improves understanding of rare disease genetics using genomic approaches

In 2018, Dr. Claudia Gonzaga-Jáuregui, who years before had completed her doctorate studies in Dr. James R. Lupski's lab at Baylor College of Medicine, received an email from an editor at Elsevier's Academic Press with a proposal that immediately caught her attention.

25 Jun 2021

Study introduces a new, improved CRISPR 3.0 system in plants

In a study in Nature Plants, Yiping Qi, associate professor of Plant Science at the University of Maryland (UMD), introduces a new and improved CRISPR 3.0 system in plants, focusing on gene activation instead of traditional gene editing.

25 Jun 2021

Genomics

Optical genome mapping could change the existing workflow within cytogenetic laboratories

Uncovering cellular mechanism related to gene silencing therapies

NYUAD researchers unlock an epigenetic code that allows liver regeneration

Comprehensive genetic study provides new insights on cleft lip and palate

Brain cells snap DNA strands in numerous locations to make memories

Castration of male sheep slows DNA aging

New genetic biobank could hold the key to preventing SIDS

Genetic variants in a neuro-associated gene cause neurodevelopmental disorder, finds study

Scientists discover genetic basis and molecular mechanisms of new neurodevelopmental syndrome

Study offers clues for earlier diagnosis of folate deficiency

Researchers discover genetic markers that drive the timing of first sex and birth

Reduced function of key gene may affect communication between motor neurons and muscles in ALS

New method to transport RNA-based drugs to subpopulation of immune cells

DNA sequencing from water and leech bloodmeals helps identify novel mammalian viruses

RAMBO can cut indexing times for huge DNA databases

New analysis links distinct patterns of genetic mutations with OCD

First CRISPR-Cas9-based gene drive cuts and copies genetic elements in Arabidopsis plants

TET enzymes play key role in keeping immune cells on a healthy track

New book improves understanding of rare disease genetics using genomic approaches

Study introduces a new, improved CRISPR 3.0 system in plants

Evolving spectrophotometry for modern biopharma workflows

Scaling B-cell cloning workflows for antibody development

Fluidics in Modern Healthcare & Medical Device Innovation

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