Genomics

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SPRK1 enzyme plays role in reorganizing the paternal genome during fertilization

A sperm enters an egg, an embryo develops and eventually a baby is born. But back up a second -- how does the mother's half-genome actually merge with the father's half-genome to form one new human genome?

13 Mar 2020

Researchers reveal nerve circuitry regulating worms' response to changing temperatures

Nagoya University researchers and colleagues have revealed the nerve circuitry regulating the response of a tiny soil worm to changing temperatures.

13 Mar 2020

New nano strategy for 'trapping and zapping' antibiotic resistant genes

It's not enough to take antibiotic-resistant bacteria out of wastewater to eliminate the risks they pose to society. The bits they leave behind have to be destroyed as well.

12 Mar 2020

People want more money, control in exchange for genomic data

Genomic data donated by the public is valuable for the companies that collect it. But a recent survey finds that once people are aware of issues surrounding the use and security of genetic information, people are more concerned about how it might be used and expect to be better compensated for providing it.

11 Mar 2020

Researchers probe how specific genes can impact early brain development

When brains begin developing, there are a lot of moving parts -- and when mutations happen in early neurodevelopment, it can lead to disorders like macrocephaly and autism.

11 Mar 2020

Canine study discovers novel genes associated with hip dysplasia and osteoarthritis

Hip dysplasia, common in both dogs and humans, and associated osteoarthritis are complex disorders influenced by a multitude of genes.

11 Mar 2020

Exploiting careless cancer cells to develop new drugs

Could the ability of cancer cells to quickly alter their genome be used as a weapon against malignant tumors? Researchers at Uppsala University have succeeded in developing a substance that has demonstrated promising results in experiments on both animal models and human cancer cells.

11 Mar 2020

CRISPR-Cas system can be used to effectively target colitis pathogen

Research at North Carolina State University shows that the CRISPR-Cas system can be used to effectively target and eliminate specific gut bacteria, in this case Clostridioides difficile, the pathogen that causes colitis - a chronic, degenerative disease of the colon.

10 Mar 2020

New toolkit to repair DNA breaks linked to aging, cancer and MND discovered

A new 'toolkit' to repair damaged DNA that can lead to aging, cancer and Motor Neurone Disease has been discovered by scientists at the Universities of Sheffield and Oxford.

9 Mar 2020

Preclinical data of Ocugen's OCU400 genetic modifier published in Nature Gene Therapy

Ocugen, Inc., a clinical-stage company focused on discovering, developing and commercializing transformative therapies to treat rare and underserved ophthalmic diseases, announced today the publication in Nature Gene Therapy of preclinical data of nuclear hormone receptor gene NR2E3 as a genetic modifier and therapeutic agent to treat multiple retinal degenerative diseases.

3 Mar 2020

Functioning amyloid found in healthy brain

Scientists from St Petersburg University worked with their colleagues from the St Petersburg branch of the Vavilov Institute of General Genetics.

2 Mar 2020

Length of pregnancy related to chemical DNA changes in newborns

Researchers from Karolinska Institutet in Sweden have together with an international team mapped the relationship between length of pregnancy and chemical DNA changes in more than 6,000 newborn babies.

2 Mar 2020

New genetic tool developed to label specific genes in human organoids

Researchers from the group of Hans Clevers at the Hubrecht Institute have developed a new genetic tool to label specific genes in human organoids, or mini organs.

2 Mar 2020

New discovery may be useful for developing novel cancer treatments

Researchers from the University of Copenhagen have discovered that our cells replicate their DNA much more loosely than previously thought.

28 Feb 2020

New approach to identify pathogenic genes in virus strains at a glance

When new viruses or bacteria spread to humans, it is essential to clarify their special characteristics as quickly as possible.

27 Feb 2020

First human vaginal non-redundant gene catalog released

University of Maryland School of Medicine's Institute for Genome Sciences researchers have created the first catalog of genes that comprise the community of microbes, which inhabit the human vagina.

26 Feb 2020

Blue light illuminates key ALS pathologies in zebrafish

A joint research group in Japan has succeeded in reproducing key ALS symptoms in a small tropical fish by remote controlling a disease-associated protein molecule using light illumination.

26 Feb 2020

Gene-editing is more error-prone than thought, new findings suggest

The standard gene-editing tool, CRISPR-Cas9, frequently produces a type of DNA mutation that ordinary genetic analysis misses, claims new research published in the journal Proceedings of the National Academy of Sciences.

26 Feb 2020

Genome research collaboration in Finland welcomes Janssen and Maze Therapeutics

FinnGen, a large-scale academic - industry, genome research collaboration in Finland now includes eleven industry partners with the addition of the Janssen Pharmaceutical Companies of Johnson & Johnson and Maze Therapeutics.

25 Feb 2020

Cultural transition to agriculture linked with emergence of human-adapted pathogens

Using Salmonella enterica genomes recovered from human skeletons as old as 6,500 years, an international team of researchers illustrates the evolution of a human pathogen and provides the first ancient DNA evidence in support of the hypothesis that the cultural transition from foraging to farming facilitated the emergence of human-adapted pathogens that persist until today.

25 Feb 2020