Genomics

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Researchers discover transposon-encoded RNA-guided nucleases with potential for genome editing

Researchers seeking to understand the origins of CRISPR-Cas9 systems have uncovered a class of transposon-encoded RNA-guided nucleases, which they dubbed "OMEGA," that could be harnessed for genome editing in human cells.

12 Sep 2021

New precision-guided sterile insect technique designed to control disease-spreading mosquitoes

Leveraging advancements in CRISPR-based genetic engineering, researchers at the University of California San Diego have created a new system that restrains populations of mosquitoes that infect millions each year with debilitating diseases.

11 Sep 2021

Genomic surveillance of SARS-CoV-2 reveals how the pandemic was caused in Africa

A genomic surveillance analysis of SARS-CoV-2 in Africa in the first year of the pandemic reveals that the first phase of the pandemic there was caused by importations from outside Africa, and involved limited virus spread, while the second, more deadly phase was fueled by ongoing transmission within the continent and led to emergence of many variants of concern.

10 Sep 2021

Washington University School of Medicine receives $7 million to investigate how human genome works

Washington University School of Medicine in St. Louis has received a $7 million grant from the National Institutes of Health to help lead national efforts to investigate how variations in the human genome sequence affect how the genome functions.

9 Sep 2021

UC San Diego researchers receive $6 million NIH grant to study insulin-producing cells

Sequencing the human genome - a feat accomplished in 2003 - provided the list of ingredients that make up a human being, but not the instructions that explain how those ingredients are used by each cell type to create complex "meals."

9 Sep 2021

New gene-delivering workhorse could make gene therapy safer, more effective for muscle diseases

Genetic muscle diseases lead to progressive muscle wasting and often early death, with few treatment options and no cure.

9 Sep 2021

IGVF consortium receives NIH funding to study how genomic variation influences biological function

The National Institutes of Health is providing approximately $185 million over five years to the Impact of Genomic Variation on Function consortium, initiated and funded by NIH's National Human Genome Research Institute.

9 Sep 2021

Highly extensive Gut Cell Atlas will transform research into intestinal diseases

Many diseases have their origin in early human development, and today (8th September), two publications in Nature reveal how researchers from the Human Cell Atlas (HCA) consortium are advancing understanding of this.

9 Sep 2021

Understanding how pathogens evolve novel virulence activities

Understanding how pathogens evolve is a fundamental component of learning how to protect ourselves and our world from pests and diseases.

7 Sep 2021

New open-access repository of FAQs on human genomic research counters misinformation

New research on the genomic influences on traits such as intelligence, household income, and sexual behavior captures public attention, but it is also used to justify beliefs in racial and social inequalities.

7 Sep 2021

Research reveals a previously unknown role for a key transcription regulator linked to cancer

CTCF is a transcription factor that has been a research target due to its role in regulating a critical oncogene called MYC.

7 Sep 2021

Increased infectivity and immune evasion drive the spread of Delta SARS-CoV-2 variant

Findings suggest infection control measures against variants will need to continue in the post-vaccination era.

6 Sep 2021

New insights could help unlock the mystery of how lung cancer arises in never smokers

A genomic analysis of lung cancer in people with no history of smoking has found that a majority of these tumors arise from the accumulation of mutations caused by natural processes in the body.

6 Sep 2021

Researchers develop the smallest CRISPR to date for genome editing

A compact and efficient CRISPR-Cas system, named CasMINI, could be broadly useful for cell-engineering and gene-therapy applications because it is easier to deliver into cells. The findings appear in a study publishing September 3 in the journal Molecular Cell.

4 Sep 2021

Stanford researchers engineer an efficient, multi-purpose, mini CRISPR system

The common analogy for CRISPR gene editing is that it works like molecular scissors, cutting out select sections of DNA. Stanley Qi, assistant professor of bioengineering at Stanford University, likes that analogy, but he thinks it's time to reimagine CRISPR as a Swiss Army knife.

4 Sep 2021

Growing wheat varieties with biological nitrification inhibition trait could increase yields

An international collaboration has discovered and transferred to elite wheat varieties a wild-grass chromosome segment that causes roots to secrete natural inhibitors of nitrification, offering a way to dial back on heavy fertilizer use for wheat and to reduce the crop's nitrogen leakage into waterways and air, while maintaining or raising its productivity and grain quality, says a new report in the Proceedings of the National Academy of Sciences of the United States of America.

2 Sep 2021

Study suggests a biological basis behind instantaneous compatibility reaction

Have you ever met someone you instantly liked, or at other times, someone who you knew immediately that you did not want to be friends with, although you did not know why?

2 Sep 2021

Genomic autopsy reveals many genetic variants associated with cardiomyopathy

Postmortem genetic testing, or genomic autopsy, of young individuals who experienced sudden death revealed many had known genetic variants that are associated with cardiomyopathy, according to a Northwestern Medicine study published in JAMA Cardiology.

31 Aug 2021

Study uses novel technology to map the brain circuitry of spirituality

Scientists have long suspected that religiosity and spirituality could be mapped to specific brain circuits, but the location of those circuits remains unknown. Now, a new study using novel technology and the human connectome, a map of neural connections, has identified a brain circuit that seems to mediate that aspect of our personality. The work appears in Biological Psychiatry, published by Elsevier.

31 Aug 2021

New, one-stop method developed to avoid de novo genetic disease in embryos

De novo variants (DNVs), genetic mutations that were not previously identifiable in the family history of one of two prospective parents, may cause disease in any children they have.

31 Aug 2021

Genomics

Researchers discover transposon-encoded RNA-guided nucleases with potential for genome editing

New precision-guided sterile insect technique designed to control disease-spreading mosquitoes

Genomic surveillance of SARS-CoV-2 reveals how the pandemic was caused in Africa

Washington University School of Medicine receives $7 million to investigate how human genome works

UC San Diego researchers receive $6 million NIH grant to study insulin-producing cells

New gene-delivering workhorse could make gene therapy safer, more effective for muscle diseases

IGVF consortium receives NIH funding to study how genomic variation influences biological function

Highly extensive Gut Cell Atlas will transform research into intestinal diseases

Understanding how pathogens evolve novel virulence activities

New open-access repository of FAQs on human genomic research counters misinformation

Research reveals a previously unknown role for a key transcription regulator linked to cancer

Increased infectivity and immune evasion drive the spread of Delta SARS-CoV-2 variant

New insights could help unlock the mystery of how lung cancer arises in never smokers

Researchers develop the smallest CRISPR to date for genome editing

Stanford researchers engineer an efficient, multi-purpose, mini CRISPR system

Growing wheat varieties with biological nitrification inhibition trait could increase yields

Study suggests a biological basis behind instantaneous compatibility reaction

Genomic autopsy reveals many genetic variants associated with cardiomyopathy

Study uses novel technology to map the brain circuitry of spirituality

New, one-stop method developed to avoid de novo genetic disease in embryos

Evolving spectrophotometry for modern biopharma workflows

Scaling B-cell cloning workflows for antibody development

Fluidics in Modern Healthcare & Medical Device Innovation

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