Genomics

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Finding the genetic cause of childhood epilepsy helps improve treatment and care

Epilepsy is one of the most common chronic neurological diseases, affecting more than 50 million people worldwide. Although it is believed that a large proportion of childhood-onset epilepsies are caused by genetic changes, it remains unknown precisely how many of these patients suffer from a genetic disorder and how often the treatment can be targeted to their specific genetic alteration.

31 Aug 2021

Study identifies actionable genes and candidate drugs in biliary tract cancer using a knowledgebase

Oncotarget published "Actionability evaluation of biliary tract cancer by genome transcriptome analysis and Asian cancer knowledgebase" which reported that it is necessary to investigate actionable genes and candidate drugs using a sophisticated knowledgebase and characterize BTCs immunologically for evaluating the actionability of molecular and immune therapies.

31 Aug 2021

Research sheds light on potential biological mechanisms that impact adherence to medications

How strictly patients follow a prescribed drug treatment (drug adherence) is clearly important if the therapy is to have maximum effect. A number of things can affect adherence, including behavioral and socioeconomic factors, but to date there have been few investigations into the role played by genetics. Now, research to be presented at the annual conference of the European Society of Human Genetics today has thrown new light on the potential biological mechanisms that can affect adherence to treatment.

31 Aug 2021

Polygenic risk scores could be used as a tool to help diagnose epilepsy

Although epilepsy is a relatively common condition, affecting approximately 1% of individuals worldwide, it is often difficult to diagnose in clinical practice, and it is estimated that up to a quarter of all cases may be misdiagnosed initially.

30 Aug 2021

Molecular autopsy of dried blood spots can identify underlying cause of sudden cardiac death in a young person

The underlying cause of sudden cardiac death (SCD) in a young person is often difficult to identify. A genetic analysis could provide more information in many cases, but blood samples are not collected routinely at the time of death, and DNA extracted from the tissues collected at autopsy is damaged because of the way they are fixed in formalin and paraffin-embedded.

30 Aug 2021

Oral bacteria of wild Swedish brown bears reveal history of human antibiotic use

An international team of researchers used historical museum collections to study the effects of human-made antibiotics over the entire history of their application.

27 Aug 2021

Large analysis identifies 579 genetic locations linked to anti-social behavior and addiction

An analysis of data from 1.5 million people has identified 579 locations in the genome associated with a predisposition to different behaviors and disorders related to self-regulation, including addiction and child behavioral problems.

27 Aug 2021

New MOGONET outperforms existing supervised multi-omics integrative analysis approaches

Genomics, proteomics, metabolomics, transcriptomics -- rapid advances in high-throughput biomedical technologies has enabled the collection of data with unprecedented detail from the growing number of omics.

27 Aug 2021

Study identifies 579 genomic regions associated with predisposition to self-regulating behaviors

Researchers have identified 579 locations in the human genome associated with a predisposition to self-regulation-related behaviors, including addiction and child behavioral problems. With data from 1.5 million people of European descent, the effort is considered to be one of the largest genome-wide association studies to date.

26 Aug 2021

Genetic background linked to elevated risk of omega-3 deficiency in Hispanic Americans

Hispanic people with a high percentage of American Indigenous ancestry are at increased risk of a nutritional deficiency that could affect their heart health and contribute to harmful inflammation, new research suggests.

26 Aug 2021

Researchers identify numerous genetic regions that may affect individuals' food intake

A team of researchers at Massachusetts General Hospital, Boston University School of Public Health, and other institutions have identified more than two dozen genetic regions that may affect individuals' food intake.

25 Aug 2021

Study provides new insight into the mosquito immune system and disease transmission

A new study that details mosquito immune cells could shed light on the insect immune system and how mosquitoes transmit parasites that cause malaria.

25 Aug 2021

Lack of inflammatory genes makes carnivores the biggest carriers of zoonotic pathogens

Carnivorous animals lack key genes needed to detect and respond to infection by pathogens, a study has found.

24 Aug 2021

Researchers discover molecule that plays an important role in sperm motility regulation

About 120 million unintended pregnancies occurred each year between 2015 and 2019 worldwide. While there are oral contraceptives for women, the development of oral contraceptives for men has not been successful.

24 Aug 2021

Researchers use gene editing to render male mosquitoes infertile and slow disease spread

Mosquitos spread viruses that cause potentially deadly diseases such as Zika, dengue fever and yellow fever. New U.S. Army-funded research uses gene editing to render certain male mosquitoes infertile and slow the spread of these diseases.

23 Aug 2021

Analysis of seadragon genome offers new insights into its phenotype and sex-determination locus

A study by Prof. LIN Qiang from the South China Sea Institute of Oceanology (SCSIO) of the Chinese Academy of Sciences and his collaborators from Singapore and Germany lifts the veil on seadragons' mysterious looks, and sheds light on a sex-determination locus shared by seadragons and alligator pipefish, both members of the Syngnathidae family.

22 Aug 2021

Rice University awarded $4 million CPRIT grant to establish Genetic Design and Engineering Center

Rice University faculty members led by bioengineer Gang Bao have been awarded a $4 million grant by the Cancer Prevention and Research Institute of Texas to establish the Genetic Design and Engineering Center.

20 Aug 2021

Researchers develop an integrative approach to boost accuracy of mosquito vector surveillance

A team of researchers from the National University of Singapore, led by Assistant Professor Nalini Puniamoorthy from the Department of Biological Sciences, has developed an integrative approach that increases the accuracy of mosquito surveillance and management.

20 Aug 2021

SARS-CoV-2 mutations alter dynamics of neutralizing antibodies

A new study describes how monoclonal antibodies raised against SARS-CoV-2 are affected by mutations in the antibody binding site.

20 Aug 2021

SARS-CoV-2 lambda variant escapes immune response via spike mutations

A new study explores the mechanism by which the SARS-CoV-2 lambda variant has acquired immune evasion capabilities above that of the wildtype.

20 Aug 2021

Genomics

Finding the genetic cause of childhood epilepsy helps improve treatment and care

Study identifies actionable genes and candidate drugs in biliary tract cancer using a knowledgebase

Research sheds light on potential biological mechanisms that impact adherence to medications

Polygenic risk scores could be used as a tool to help diagnose epilepsy

Molecular autopsy of dried blood spots can identify underlying cause of sudden cardiac death in a young person

Oral bacteria of wild Swedish brown bears reveal history of human antibiotic use

Large analysis identifies 579 genetic locations linked to anti-social behavior and addiction

New MOGONET outperforms existing supervised multi-omics integrative analysis approaches

Study identifies 579 genomic regions associated with predisposition to self-regulating behaviors

Genetic background linked to elevated risk of omega-3 deficiency in Hispanic Americans

Researchers identify numerous genetic regions that may affect individuals' food intake

Study provides new insight into the mosquito immune system and disease transmission

Lack of inflammatory genes makes carnivores the biggest carriers of zoonotic pathogens

Researchers discover molecule that plays an important role in sperm motility regulation

Researchers use gene editing to render male mosquitoes infertile and slow disease spread

Analysis of seadragon genome offers new insights into its phenotype and sex-determination locus

Rice University awarded $4 million CPRIT grant to establish Genetic Design and Engineering Center

Researchers develop an integrative approach to boost accuracy of mosquito vector surveillance

SARS-CoV-2 mutations alter dynamics of neutralizing antibodies

SARS-CoV-2 lambda variant escapes immune response via spike mutations

Evolving spectrophotometry for modern biopharma workflows

Scaling B-cell cloning workflows for antibody development

Fluidics in Modern Healthcare & Medical Device Innovation

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