Genomics

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Study identifies 29 new genetic variants linked to acne

A study of the genetics of acne has identified 29 regions of the genome that influence the condition. These genetic insights offer potential new targets for treatment. They may also help clinicians identify individuals at high risk of severe disease.

7 Feb 2022

Scientists reveal how droplets of transcription factors collectively read DNA regions to switch on genes

Life starts with one cell. When an organism develops, dividing cells specialize to form the variety of tissues and organs that build up the adult body, while keeping the same genetic material – contained in our DNA.

6 Feb 2022

Genomes of marine invertebrates found to be surprisingly stable across deep time

Scientists have discovered that the genomes of marine invertebrates have been surprisingly stable across deep time.

6 Feb 2022

Gene therapy helps heart muscle cells electrically activate in live mice

Biomedical engineers at Duke University have demonstrated a gene therapy that helps heart muscle cells electrically activate in live mice.

4 Feb 2022

Evaluating effects of D614G and P681R/H mutations on SARS-CoV-2 VOCs

Researchers evaluate how the D614G and P681H mutations alter the attributes of SARS-CoV-2 VOCs.

3 Feb 2022

Scientists identify genome regions linked to migraine risk

An international consortium of leading migraine scientists identified more than 120 regions of the genome that are connected to risk of migraine.

3 Feb 2022

Study identifies a genetic mutation linked to high risk of lethal childhood leukemia

A genetic variant changing just one base pair of nucleotides greatly increases risk of a high-risk subtype of childhood acute lymphoblastic leukemia (ALL), according to a Northwestern Medicine study published in Nature Genetics.

3 Feb 2022

CRISPRa method helps discover genes that play a role in immune cell biology

CRISPR genome editing has served as a powerful tool for deleting or altering DNA sequences and studying the resulting effect.

3 Feb 2022

Genome study reveals unexpected heterogeneity of human ribosomal RNA genes

A genome study undertaken by Johns Hopkins Kimmel Cancer Center researchers to look for variants in a gene considered a fundamental building block for microscopic structures that synthesize proteins took a surprising twist.

2 Feb 2022

Three different autism risk genes found to have similar effects on brain development

Autism spectrum disorder has been associated with hundreds of different genes, but how these distinct genetic mutations converge on a similar pathology in patients has remained a mystery.

2 Feb 2022

UCLA researchers develop first human genomic transgenic mouse model of Huntington's disease

Researchers at the Jane and Terry Semel Institute for Neuroscience and Human Behavior at UCLA and the David Geffen School of Medicine at UCLA have developed a new mouse model of Huntington's disease that recapitulates more Huntington's disease-like characteristics than earlier models.

2 Feb 2022

'Genetic scissors' can give rise to unforeseen heritable mutations

CRISPR-Cas9, the "genetic scissors", creates new potential for curing diseases; but treatments must be reliable. In a new study, researchers have discovered that the method can give rise to unforeseen changes in DNA that can be inherited by the next generation.

2 Feb 2022

Gut bacteria transfer genes through sex to take vitamin B12, study shows

Your gut bacteria need vitamin B12 just as much as you do. Though DNA is usually passed from parent to child, new research shows gut bacteria transfer genes through "sex" in order to take their vitamins.

2 Feb 2022

Study finds minimal genetic difference between healthy sea stars and those with wasting syndrome

Healthy-looking ochre sea stars have minimal genetic difference from those displaying symptoms of sea star wasting syndrome, say Oregon State University researchers who examined whether genetic variation was the reason some animals went unaffected during an epidemic of the deadly disease.

2 Feb 2022

Dexamethasone administration at a late time point could enhance transgene expression

Dexamethasone, a glucocorticoid with anti-inflammatory and immunosuppressive effects, can transiently increase the expression of therapeutic genes delivered using adeno-associated virus (AAV) vectors.

31 Jan 2022

New study on mutation origination fundamentally challenges neo-Darwinism

A new study by a team of researchers from Israel and Ghana has brought the first evidence of nonrandom mutation in human genes, challenging a core assumption at the heart of evolutionary theory by showing a long-term directional mutational response to environmental pressure.

31 Jan 2022

Study identifies high-priority genes associated with uterine cancer that could be potential drug targets

No single gene causes uterine cancer, the fourth most common cancer among women, which is on the rise in the U.S.

28 Jan 2022

Oligodendrocytes may have a different role in the development of multiple sclerosis, study finds

An international team of researchers led by Karolinska Institutet in Sweden have discovered that a cell type in the central nervous system known as oligodendrocytes might have a different role in the development of multiple sclerosis (MS) than previously thought.

28 Jan 2022

Study identifies genetic link between early maturation and high aerobic performance in juvenile salmon

A study conducted at the University of Helsinki indicates that early sexual maturation and high aerobic performance in salmon have a genetic link that is already evident in juvenile salmon.

28 Jan 2022

ERGA aims to provide genomic data to inform research about Europe's biodiversity

To provide important genomic data to inform research about Europe's biodiversity, scientists from 48 different countries initiated the "European Reference Genome Atlas" (ERGA) in 2021.

28 Jan 2022

Genomics

Study identifies 29 new genetic variants linked to acne

Scientists reveal how droplets of transcription factors collectively read DNA regions to switch on genes

Genomes of marine invertebrates found to be surprisingly stable across deep time

Gene therapy helps heart muscle cells electrically activate in live mice

Evaluating effects of D614G and P681R/H mutations on SARS-CoV-2 VOCs

Scientists identify genome regions linked to migraine risk

Study identifies a genetic mutation linked to high risk of lethal childhood leukemia

CRISPRa method helps discover genes that play a role in immune cell biology

Genome study reveals unexpected heterogeneity of human ribosomal RNA genes

Three different autism risk genes found to have similar effects on brain development

UCLA researchers develop first human genomic transgenic mouse model of Huntington's disease

'Genetic scissors' can give rise to unforeseen heritable mutations

Gut bacteria transfer genes through sex to take vitamin B12, study shows

Study finds minimal genetic difference between healthy sea stars and those with wasting syndrome

Dexamethasone administration at a late time point could enhance transgene expression

New study on mutation origination fundamentally challenges neo-Darwinism

Study identifies high-priority genes associated with uterine cancer that could be potential drug targets

Oligodendrocytes may have a different role in the development of multiple sclerosis, study finds

Study identifies genetic link between early maturation and high aerobic performance in juvenile salmon

ERGA aims to provide genomic data to inform research about Europe's biodiversity

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