Genomics

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Research provides compelling insights into the complex nature of genomic imprinting in mice

Mammalian offspring inherit two versions, or alleles, of each gene with one allele from each biological parent. However, gene expression is tightly regulated and certain genes undergo the phenomenon of "genomic imprinting", which is where only the allele received by the male or the female parent is expressed.

4 Jan 2022

Experts cautiously optimistic about risks of Delta-Omicron mutations mix

Researchers evaluate the risk of the P681R, N501Y, and D614G mutations of current interest co-occurring naturally due to convergent evolution.

4 Jan 2022

Production of molecular probes of spike and subdomains for all SARS-CoV-2 variants

Researchers designed molecular probes of diverse SARS-CoV-2 variants and evaluated their antibody binding specificity.

3 Jan 2022

The impact of natural selection on sequence diversity in SARS-CoV-2

Recent genomic analysis demonstrates that the SARS-CoV-2 genome is under two distinct selective forces.

3 Jan 2022

Genomic sequencing supports a long-term infection as source of SARS-CoV-2 Omicron

Researchers study the nucleotide sequences of the newly emerged SARS-CoV-2 Omicron variant with other nucleotide sequences in the GISAID database.

3 Jan 2022

Omicron analysis shows no clear evidence for increased virulence or lethality

Researchers conducted a genomic sequencing and epidemiological correlation analysis of the SARS-CoV-2 Omicron variant.

29 Dec 2021

New study targets the methylation profile of microglia from human brain

In the central nervous system, microglial cells play critical roles in development, aging, brain homeostasis, and pathology. Recent studies have shown variation in the gene-expression profile and phenotype of microglia across brain regions and between different age and disease states.

29 Dec 2021

Scientists detect COVID-19 infection in white-tailed deer in 6 Ohio locations

Scientists have detected infection by at least three variants of the virus that causes COVID-19 in free-ranging white-tailed deer in six northeast Ohio locations, the research team has reported.

24 Dec 2021

Recently evolved region of the ‘dark genome’ provides clues to treatment of schizophrenia, bipolar disorder

Scientists investigating the DNA outside our genes - the 'dark genome' - have discovered recently evolved regions that code for proteins associated with schizophrenia and bipolar disorder.

23 Dec 2021

Eating sugar is healthy for some Greenlanders with a genetic variation

A genetic variation among some Greenlanders makes sugar healthy – significantly more than for most people.

22 Dec 2021

Researchers use network modeling to hone in on cancer gene interactions critical to malignancy

Wilmot Cancer Institute researchers are a step closer to understanding the complex gene interactions that cause a cell to become malignant.

21 Dec 2021

Deletion of autism-linked gene diminishes myelin in mice

Myelin, a sheath of insulation around nerves that enables electrical impulses to efficiently travel through the central nervous system, is diminished in mice that have a gene deletion associated with autism spectrum disorder, new research finds.

21 Dec 2021

Cheap and accessible methods for genome sequencing will help tackle future pandemics

A worldwide consortium of scientists, led by the Earlham Institute and the University of Liverpool in the UK, mark a significant milestone in equipping researchers in low- and middle-income countries (LMICs) with cheap and accessible methods for sequencing large collections of bacterial pathogens - at a cost of less than $10USD per genome.

21 Dec 2021

Researchers use machine learning to shed light on genetic mutations linked with spina bifida

Weill Cornell Medicine researchers are using machine learning, a form of artificial intelligence, to shed light on genetic mutations associated with spina bifida.

20 Dec 2021

UBR7 protein acts as a histone chaperone during DNA replication, study finds

The protein UBR7 acts as a histone chaperone, regulating histone re-deposition at specific sites during DNA replication, according a recent study published in The EMBO Journal.

20 Dec 2021

Genomic study of furin cleavage sites validates the natural evolutionary origin of SARS-CoV-2 in bats

A team of researchers describes the genomic region encompassing the furin cleavage site in SARS-CoV-2.

20 Dec 2021

Genome-wide ancient human DNA data from Sudan reveals new insights into the Nile Valley past

The first genome-wide ancient human DNA data from Sudan reveals new insights into the ancestry and social organization of people who lived more than 1,000 years ago in the Nile Valley, an important genetic and cultural crossroads.

20 Dec 2021

Researchers receive CZI grant to support Asian Immune Diversity Atlas project

A team of researchers, led by the Agency for Science, Technology and Research's Genome Institute of Singapore (GIS), was awarded the prestigious Chan Zuckerberg Initiative Ancestry Network Grant in support of their Asian Immune Diversity Atlas (AIDA) project.

18 Dec 2021

Services to accelerate genome editing research

AMSBIO has expanded its range of custom gene editing services to complement its extensive portfolio of off-the-shelf CRISPR/Cas9 products.

From AMS Biotechnology 17 Dec 2021

Study: Common gene mutation for Parkinson's disease drives mislocalization of iron in the brain

A common gene mutation for Parkinson's disease drives mislocalization of iron in activated microglia, according to a new study publishing December 16th in the open-access journal PLOS Biology, by Mark Cookson of the National Institute on Aging and colleagues

17 Dec 2021

Genomics

Research provides compelling insights into the complex nature of genomic imprinting in mice

Experts cautiously optimistic about risks of Delta-Omicron mutations mix

Production of molecular probes of spike and subdomains for all SARS-CoV-2 variants

The impact of natural selection on sequence diversity in SARS-CoV-2

Genomic sequencing supports a long-term infection as source of SARS-CoV-2 Omicron

Omicron analysis shows no clear evidence for increased virulence or lethality

New study targets the methylation profile of microglia from human brain

Scientists detect COVID-19 infection in white-tailed deer in 6 Ohio locations

Recently evolved region of the ‘dark genome’ provides clues to treatment of schizophrenia, bipolar disorder

Eating sugar is healthy for some Greenlanders with a genetic variation

Researchers use network modeling to hone in on cancer gene interactions critical to malignancy

Deletion of autism-linked gene diminishes myelin in mice

Cheap and accessible methods for genome sequencing will help tackle future pandemics

Researchers use machine learning to shed light on genetic mutations linked with spina bifida

UBR7 protein acts as a histone chaperone during DNA replication, study finds

Genomic study of furin cleavage sites validates the natural evolutionary origin of SARS-CoV-2 in bats

Genome-wide ancient human DNA data from Sudan reveals new insights into the Nile Valley past

Researchers receive CZI grant to support Asian Immune Diversity Atlas project

Services to accelerate genome editing research

Study: Common gene mutation for Parkinson's disease drives mislocalization of iron in the brain

AI in Healthcare: How generative tools are transforming clinical practice

The future of automation: Machine learning–driven hepatocyte and organoid counting

From street to lab: Advancing controlled substance testing with handheld Raman and FTIR

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