Genomics

RSS

Scientists use gold nanoparticles to edit genes tied to HIV, inherited blood disorders

Scientists at Fred Hutchinson Cancer Research Center took a step toward making gene therapy more practical by simplifying the way gene-editing instructions are delivered to cells.

28 May 2019

Large-scale genomic sequencing narrows search for Strep A vaccine

The global search for a group A streptococcal (Strep A) vaccine has narrowed after researchers identified a common gene signature in almost all global Strep A strains by sequencing thousands of genomes in a project spanning 10 years and more than 20 countries.

28 May 2019

Genetically eliminating TOX factors improves eradication of solid tumors in CAR T model

A decade ago researchers announced development of a cancer immunotherapy called CAR (for chimeric antigen receptor)-T, in which a patient is re-infused with their own genetically modified T cells equipped to mount a potent anti-tumor attack.

28 May 2019

Researchers get one step closer to global Strep A vaccine

The search for a global Strep A vaccine has narrowed after researchers sequenced the DNA of more than 2000 Group A Streptococcus samples from around the world.

27 May 2019

Mutations in 'junk' DNA can cause autism, study shows

Leveraging artificial intelligence techniques, researchers have demonstrated that mutations in so-called 'junk' DNA can cause autism.

27 May 2019

Mites and ticks are part of the same evolutionary line, research shows

Scientists from the University of Bristol and the Natural History Museum in London have reconstructed the evolutionary history of the chelicerates, the mega-diverse group of 110,000 arthropods that includes spiders, scorpions, mites and ticks.

27 May 2019

Artificial intelligence technique identifies new class of mutations behind autism

Many mutations in DNA that contribute to disease are not in actual genes but instead lie in the 99% of the genome once considered "junk." Even though scientists have recently come to understand that these vast stretches of DNA do in fact play critical roles, deciphering these effects on a wide scale has been impossible until now.

27 May 2019

Newly approved gene therapy for SMA is based on delivery vehicle discovered by Penn expert

James Wilson, MD, PhD, recalls being struck by the devastating toll of rare diseases as a young physician in the 1980s. He set out on a path to correct the genes that cause these conditions, including spinal muscle atrophy (SMA), the most common inherited fatal disease in infants.

25 May 2019

Are fruit fly 'avatars' the next step in personalized medicine?

Researchers have created fruit fly “avatars” that have helped to guide treatment for a man who had terminal colon cancer.

24 May 2019

Cornell University-led study creates new standard genome for widely researched worm

A new Cornell University-led study finds that the genome for a widely researched worm, on which countless studies are based, was flawed. Now, a fresh genome sequence will set the record straight and improve the accuracy of future research.

24 May 2019

Longas offers Morphoseq technology for highly accurate long read sequencing on short read NGS platforms

Longas Technologies Pty Ltd, a developer of Next Generation Sequencing technologies, has provided details on its Morphoseq library prep and associated software technology at the ‘Sequencing, Finishing and Analysis in the Future’ meeting, May 21 – 23, Santa Fe, NM, USA, that enables long read sequencing on short read NGS platforms.

23 May 2019

Spatial configuration of the genome is not inherited, but set up during embryogenesis

The architecture of the DNA-protein complexes that make up the genome in each cell nucleus regulates the course of early embryonic development.

23 May 2019

Scientists uncover unique set of genes that play a role in muscle cellular gene regulation

York University scientists have uncovered a unique set of genes that play a role in muscle cellular gene expression and differentiation which could lead to new therapeutic targets to prevent the spread of muscle cancer.

23 May 2019

Large study links rare DNA alterations to type 2 diabetes

An international consortium of scientists has analyzed protein-coding genes from nearly 46,000 people, linking rare DNA alterations to type 2 diabetes.

23 May 2019

Genetic switch that controls conversion of bad to good fat identified

Fat cells. They are the bane of a dieter's existence, but fat is important. Previous studies showed the subcutaneous white fat cells can transform to brown and beige varieties when exposed to cold stress.

23 May 2019

Scientists develop new genetic tool to modify and understand gene function

Scientists of the National Center for Cardiovascular Research led by Rui Benedito have developed a new genetic tool (iSuRe-Cre) that provides certainty in Cre-inducible genetic modifications, a key technique for understanding gene function.

22 May 2019

Yeast species thrives, despite losing DNA repair genes years ago

Researchers have discovered an ancient species of budding yeast that has lost dozens of DNA repair genes, without any adverse effects.

22 May 2019

Newly discovered molecules safely halt the gene editing process

Scientists have discovered two non-toxic molecules that safely halt the CRISPR-Cas9 gene editing process.

22 May 2019

Scientists create bacteria with man-made DNA

In a landmark research study, a living organism (E. coli) has been made using entirely human-made DNA.

21 May 2019

Archaeological evidence shows anatomically modern humans were roasting and eating plant starches

New discoveries made at the Klasies River Cave in South Africa's southern Cape, where charred food remains from hearths were found, provide the first archaeological evidence that anatomically modern humans were roasting and eating plant starches, such as those from tubers and rhizomes, as early as 120,000 years ago.

20 May 2019

Genomics

Scientists use gold nanoparticles to edit genes tied to HIV, inherited blood disorders

Large-scale genomic sequencing narrows search for Strep A vaccine

Genetically eliminating TOX factors improves eradication of solid tumors in CAR T model

Researchers get one step closer to global Strep A vaccine

Mutations in 'junk' DNA can cause autism, study shows

Mites and ticks are part of the same evolutionary line, research shows

Artificial intelligence technique identifies new class of mutations behind autism

Newly approved gene therapy for SMA is based on delivery vehicle discovered by Penn expert

Are fruit fly 'avatars' the next step in personalized medicine?

Cornell University-led study creates new standard genome for widely researched worm

Longas offers Morphoseq technology for highly accurate long read sequencing on short read NGS platforms

Spatial configuration of the genome is not inherited, but set up during embryogenesis

Scientists uncover unique set of genes that play a role in muscle cellular gene regulation

Large study links rare DNA alterations to type 2 diabetes

Genetic switch that controls conversion of bad to good fat identified

Scientists develop new genetic tool to modify and understand gene function

Yeast species thrives, despite losing DNA repair genes years ago

Newly discovered molecules safely halt the gene editing process

Scientists create bacteria with man-made DNA

Archaeological evidence shows anatomically modern humans were roasting and eating plant starches

Evolving spectrophotometry for modern biopharma workflows

Scaling B-cell cloning workflows for antibody development

Fluidics in Modern Healthcare & Medical Device Innovation

Latest Life Science News