Genomics

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Researchers comprehensively sequence the human immune system

For the first time ever, researchers are comprehensively sequencing the human immune system, which is billions of times larger than the human genome. In a new study published in Nature from the Human Vaccines Project, scientists have sequenced a key part of this vast and mysterious system -- the genes encoding the circulating B cell receptor repertoire.

14 Feb 2019

Novel approach uses small amounts of tissue to quantify PD-L1 expression levels in tumors

Immune checkpoint inhibitors, such as the anti-PD-1 antibody pembrolizumab, have become important tools for managing non-small-cell lung cancer.

14 Feb 2019

Oxford Genetics appoints Jocelyne Bath as new Chief Operating Officer

Oxford Genetics, a leader in innovative synthetic biology-based technologies for biologics discovery, development and delivery, announces the appointment of their new Chief Operating Officer, Jocelyne Bath.

From OXGENE 13 Feb 2019

New process efficiently reprograms stem cells in one step using measles virus vector

Induced pluripotent stem cells, the workhorse of many regenerative medicine projects, start out as differentiated cells that are reprogrammed to pluripotent stem cells by exposure to a complex set of genetic cocktails.

13 Feb 2019

Microbiologists identify enzyme that makes Helicobacter so adaptable

The bacterial pathogen Helicobacter pylori owes its worldwide distribution to its genetic adaptability. Ludwig-Maximilians-Universitaet Munich microbiologists have identified an enzyme that plays a vital role in the flexible control of global gene expression in the species.

13 Feb 2019

NIH scientists zero in on genes associated with AMD

National Eye Institute scientists led a collaborative study and zeroed in on genes associated with age-related macular degeneration, a leading cause of vision loss and blindness among people age 65 and older.

12 Feb 2019

Researchers map extremely complex chromosome aberrations using DNA puzzle pieces

Using puzzle pieces from four different DNA analyses, researchers at Karolinska Institutet in Sweden have been able to map three extremely complex chromosome aberrations.

12 Feb 2019

Scientists develop machine-learning approach to identify source of Salmonella

A team of scientists led by researchers at the University of Georgia Center for Food Safety in Griffin has developed a machine-learning approach that could lead to quicker identification of the animal source of certain Salmonella outbreaks.

12 Feb 2019

New model sheds light on how small cell lung cancer is initiated

Scientists from Weill Cornell Medicine have developed a stem-cell-based model of small cell lung cancer that will help them understand how the disease is initiated and how it progresses.

11 Feb 2019

Research sheds light on how motor enzyme can promote genome integrity

Approximately one per cent of each organism's genome encodes helicases. Helicases are mostly known as motor enzymes that can unwrap double-stranded DNA by use of energy.

11 Feb 2019

Researchers identify genes that make Staphyloccocus bacteria resistant to treatment

A Rutgers-led team has discovered two genes that make some strains of harmful Staphyloccocus bacteria resistant to treatment by copper, a potent and frequently used antibacterial agent.

11 Feb 2019

When genomic sequencing fails to diagnose a rare disease

Routine sequencing has given unprecedented insight into the genetics of rare diseases, but genomics fails to diagnose up to half of patients who are tested. That's the problem German scientists tackled in a recent study in the journal Molecular & Cellular Proteomics.

11 Feb 2019

Scientists develop novel way with genome sequences to study widespread form of malaria

Scientists at the Institute of Genome Sciences at the University of Maryland School of Medicine have developed a novel way with genome sequences to study and better understand transmission, treat and ultimately eradicate Plasmodium vivax, the most widespread form of malaria. P. vivax is a single-celled transmitted by mosquitoes.

11 Feb 2019

New studies add more evidence for 'grandmother hypothesis,' but there are limits

Humans are unusual in that women go through menopause and stop reproducing long before reaching the end of their life expectancy.

8 Feb 2019

RNAs are involved in protein aggregation and neurodegenerative diseases, research reveals

New research reveals RNAs, which are crucial for cells to produce proteins, are also involved in protein aggregation, where proteins do not fold properly and 'clump' together into aggregates. If cells cannot clear these away, they become toxic and prevent cells working properly.

8 Feb 2019

Cloning-free Nested CRISPR uses long DNA fragments for efficient gene editing

CRISPR is a technique that is revolutionizing biomedical research through high-precision genome editing. However, even though it allows the creation or correction of mutations consisting of a single or few nucleotides with relative ease, it still possesses limitations upon introducing larger fragments of DNA in the genome.

8 Feb 2019

Insufficient sleep mirrored by DNA from blood leukocytes

An insufficient amount of sleep and qualitatively poor sleep are common among the general population. Prior studies have indicated that prolonged insufficient sleep and poor sleep quality are associated with a heightened risk of cardiovascular diseases, dementia and psychiatric disorders, particularly depression, yet the molecular mechanisms underlying this connection are not well known.

7 Feb 2019

Chloroplast retrograde signaling attenuates elongation response to shade in plants

Plants need sunlight to feed and grow. Without light, the photosynthesis, the reaction by which the plant chloroplasts convert atmospheric CO2 and water into sugars and oxygen, cannot take place.

6 Feb 2019

Kansas geologist reveals startling global spread of antibiotic-resistant microbes

A University of Kansas geologist's work in the remote High Arctic of Norway has exposed the startling global spread of antibiotic-resistant microbes -- including multidrug-resistant "superbugs" -- that could have dire implications for human health worldwide.

6 Feb 2019

Study: BldC protein in Streptomyces acts as ‘brake’ to control timing of sporulation

Streptomyces are soil-dwelling bacteria that produce approximately two-thirds of the antibiotics in current clinical use.

6 Feb 2019

Genomics

Researchers comprehensively sequence the human immune system

Novel approach uses small amounts of tissue to quantify PD-L1 expression levels in tumors

Oxford Genetics appoints Jocelyne Bath as new Chief Operating Officer

New process efficiently reprograms stem cells in one step using measles virus vector

Microbiologists identify enzyme that makes Helicobacter so adaptable

NIH scientists zero in on genes associated with AMD

Researchers map extremely complex chromosome aberrations using DNA puzzle pieces

Scientists develop machine-learning approach to identify source of Salmonella

New model sheds light on how small cell lung cancer is initiated

Research sheds light on how motor enzyme can promote genome integrity

Researchers identify genes that make Staphyloccocus bacteria resistant to treatment

When genomic sequencing fails to diagnose a rare disease

Scientists develop novel way with genome sequences to study widespread form of malaria

New studies add more evidence for 'grandmother hypothesis,' but there are limits

RNAs are involved in protein aggregation and neurodegenerative diseases, research reveals

Cloning-free Nested CRISPR uses long DNA fragments for efficient gene editing

Insufficient sleep mirrored by DNA from blood leukocytes

Chloroplast retrograde signaling attenuates elongation response to shade in plants

Kansas geologist reveals startling global spread of antibiotic-resistant microbes

Study: BldC protein in Streptomyces acts as ‘brake’ to control timing of sporulation

Evolving spectrophotometry for modern biopharma workflows

Scaling B-cell cloning workflows for antibody development

Fluidics in Modern Healthcare & Medical Device Innovation

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