Genomics

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Cloning-free Nested CRISPR uses long DNA fragments for efficient gene editing

CRISPR is a technique that is revolutionizing biomedical research through high-precision genome editing. However, even though it allows the creation or correction of mutations consisting of a single or few nucleotides with relative ease, it still possesses limitations upon introducing larger fragments of DNA in the genome.

8 Feb 2019

Insufficient sleep mirrored by DNA from blood leukocytes

An insufficient amount of sleep and qualitatively poor sleep are common among the general population. Prior studies have indicated that prolonged insufficient sleep and poor sleep quality are associated with a heightened risk of cardiovascular diseases, dementia and psychiatric disorders, particularly depression, yet the molecular mechanisms underlying this connection are not well known.

7 Feb 2019

Chloroplast retrograde signaling attenuates elongation response to shade in plants

Plants need sunlight to feed and grow. Without light, the photosynthesis, the reaction by which the plant chloroplasts convert atmospheric CO2 and water into sugars and oxygen, cannot take place.

6 Feb 2019

Kansas geologist reveals startling global spread of antibiotic-resistant microbes

A University of Kansas geologist's work in the remote High Arctic of Norway has exposed the startling global spread of antibiotic-resistant microbes -- including multidrug-resistant "superbugs" -- that could have dire implications for human health worldwide.

6 Feb 2019

Study: BldC protein in Streptomyces acts as ‘brake’ to control timing of sporulation

Streptomyces are soil-dwelling bacteria that produce approximately two-thirds of the antibiotics in current clinical use.

6 Feb 2019

Researchers describe first case of patient affected by dysfunctions in SLC28 gene family

A research team has described the first case of a patient affected by dysfunctions in a nucleoside transporter of the SLC28 gene family, which brings a set of genes which were not related to human pathologies in the scientific bibliography so far.

5 Feb 2019

Large genetic analysis of impulsiveness reveals links with psychiatric disorders

Impulsiveness and substance use share a genetic basis, according to genome-wide association studies published in JNeurosci by academic and industry researchers.

From Society for Neuroscience 5 Feb 2019

New research describes genetic switches that ignite axon formation

While the neural architecture responsible for the transmission of electrical impulses has been known for more than a century, the basic biology behind how a neuron acquires its one and only axon -- a fundamental component of how neurons communicate -- remains a mystery.

5 Feb 2019

Scientists shed light on biological process that helps production of healthy cells

Scientists have shed light on a biological process that helps the production of healthy cells, which may aid understanding of neurological diseases and other conditions.

5 Feb 2019

Mapping mutations in esophageal cancer could improve treatment options

Mutations that cause oesophageal adenocarcinoma have been mapped in unprecedented detail - unveiling that more than half could be targeted by drugs currently in trials for other cancer types.

4 Feb 2019

Study sheds new light on genetics of diabetes in Japanese population

The genetic and genomic revolutions have led to an abundance of data about the genetic factors that confer a predisposition to type 2 diabetes, alongside environmental and lifestyle-related causes.

4 Feb 2019

New research uncovers crucial link between polyamines and MYCN

The MYCN oncogene has long been known to be a key cause of a number of deadly solid tumor cancers, including neuroblastoma, which claims more lives of children under the age of 5 than any other cancer.

4 Feb 2019

Newly launched CINECA enables researchers to access clinical research data

Registered researchers will have rapid access to an "unprecedented scale" of clinical research data through the new Common Infrastructure for National Cohorts in Europe, Canada and Africa, launched today.

4 Feb 2019

Genetic testing improves diagnoses of abnormalities in developing babies

Genetic testing improves the diagnoses of abnormalities in developing babies that are picked up during ultrasound scans, scientists report today (31 January) in The Lancet.

1 Feb 2019

New genetic technique could allow scientists to study how smell affects behavior

Take a whiff when it rains after a dry spell, and breathe in the earthy scent that pervades the air. That smell comes from decomposing bacteria, and scientists call the compound geosmin.

1 Feb 2019

Rhomboid enzymes warp space to break cellular speed limit

Johns Hopkins researchers have found that rhomboid enzymes, which are special proteins that cut other proteins, are able to break the “cellular speed limit” as they move through the cell membrane.

1 Feb 2019

Oxford Genetics signs licensing agreement with Aldevron to market lentiviral packaging plasmids

Oxford Genetics, a leading innovator of biopharmaceutical technologies, has signed a licensing agreement with world-class service organization, Aldevron to bring to market a standardized range of its plasmids for lentiviral manufacture.

1 Feb 2019

Warmer water and chemical exposure influence gene expression in North American fish

Warmer water temperatures, combined with low-level exposure to chemicals already known to be harmful to aquatic life, influence the expression of genes in the offspring of an abundant North American fish species - and threaten organisms whose sex determination is sensitive to water temperature.

1 Feb 2019

Synchron and Festo introduce new ultra-high throughput DNA extraction device at SLAS 2019

During SLAS 2019, Synchron and Festo will describe the recent technology breakthrough leading to ultra-high throughput DNA extraction – up to 38,400 extractions per 24 hours.

From Society for Laboratory Automation and Screening (SLAS) 30 Jan 2019

Researchers discover how transcription factors find specific loci within DNA

Bioengineering experts have discovered that transcription factors which bind non-specifically to mitotic chromosomes are more efficient at finding their binding site within DNA during interphase.

30 Jan 2019

Genomics

Cloning-free Nested CRISPR uses long DNA fragments for efficient gene editing

Insufficient sleep mirrored by DNA from blood leukocytes

Chloroplast retrograde signaling attenuates elongation response to shade in plants

Kansas geologist reveals startling global spread of antibiotic-resistant microbes

Study: BldC protein in Streptomyces acts as ‘brake’ to control timing of sporulation

Researchers describe first case of patient affected by dysfunctions in SLC28 gene family

Large genetic analysis of impulsiveness reveals links with psychiatric disorders

New research describes genetic switches that ignite axon formation

Scientists shed light on biological process that helps production of healthy cells

Mapping mutations in esophageal cancer could improve treatment options

Study sheds new light on genetics of diabetes in Japanese population

New research uncovers crucial link between polyamines and MYCN

Newly launched CINECA enables researchers to access clinical research data

Genetic testing improves diagnoses of abnormalities in developing babies

New genetic technique could allow scientists to study how smell affects behavior

Rhomboid enzymes warp space to break cellular speed limit

Oxford Genetics signs licensing agreement with Aldevron to market lentiviral packaging plasmids

Warmer water and chemical exposure influence gene expression in North American fish

Synchron and Festo introduce new ultra-high throughput DNA extraction device at SLAS 2019

Researchers discover how transcription factors find specific loci within DNA

Real-time Raman monitoring for pharmaceutical hot melt extrusion

Synthetic Psychedelics: A Growing Public Health Concern

How the Vutara VXL simplifies single-molecule imaging

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