Genomics

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Foam-based delivery system could revolutionize gene therapies

Foam mixed with medications is already used to treat conditions such as varicose veins, hemorrhoids, wounds on the skin and even hair loss.

29 May 2024

Researchers decode spatial structure of prime editor

Joint research led by Yutaro Shuto, Ryoya Nakagawa, and Osamu Nureki of the University of Tokyo determined the spatial structure of various processes of a novel gene-editing tool called "prime editor."

29 May 2024

Understanding genetic mosaicism in human cells

In a study led by Jan Korbel at the European Molecular Biology Laboratory (EMBL) and Ashley Sanders at the Berlin Institute for Medical Systems Biology of the Max Delbrück Center (MDC-BIMSB), researchers have found that approximately one in 40 human bone marrow cells carry massive chromosomal alterations – copy number variations and chromosomal rearrangements, for example – without causing any apparent disease or abnormality.

28 May 2024

Comprehensive study provides new understandings of genomic influences on neuropsychiatric disease

A new analysis has revealed detailed information about genetic variation in brain cells that could open new avenues for the targeted treatment of diseases such as schizophrenia and Alzheimer's disease.

23 May 2024

UCLA research connects genetic risk and brain changes in autism

A groundbreaking study led by UCLA Health has unveiled the most detailed view of the complex biological mechanisms underlying autism, showing the first link between genetic risk of the disorder to observed cellular and genetic activity across different layers of the brain.

23 May 2024

Novel catalog of gene-isoform variation unveiled in the developing human brain

A team led by researchers at UCLA and the University of Pennsylvania has produced a first-of-its kind catalog of gene-isoform variation in the developing human brain.

23 May 2024

Harnessing molecular pathways governed by key gene to enhance wheat yields

A study from the University of Adelaide has discovered molecular pathways regulated by a gene traditionally used to control wheat-flowering behavior could be altered to achieve greater yields.

23 May 2024

Gene cluster expression analysis for personalized lung cancer therapy

About 30% of lung cancer patients are accessible to targeted therapy or immunotherapy based on the current criteria.

23 May 2024

Unraveling the role of MIR1 gene in Candida albicans virulence

This study is led by Professor Yan Wang (School of Pharmacy, Second Military Medical University (Naval Medical University), Shanghai, China). Her team found that the lack of MIR1 gene, which encodes mitochondrial phosphate carrier, can lead to severe virulence defects in Candida albicans.

22 May 2024

LMU study identifies dual genetic pathways increasing cardiovascular disease risk

LMU researchers have discovered two independent ways by which genetic variants increase the risk of cardiovascular diseases.

22 May 2024

Ancient viral sequences in the human genome may contribute to psychiatric disorder susceptibility

New research led by King's College London has found that thousands of DNA sequences originating from ancient viral infections are expressed in the brain, with some contributing to susceptibility for psychiatric disorders such as schizophrenia, bipolar disorder, and depression.

22 May 2024

New MOBE technology revolutionizes multiplexed genome editing

The human genome consists of around 3 billion base pairs and humans are all 99.6% identical in their genetic makeup.

21 May 2024

New CRISPR screen method reveals cellular drivers of neurological disorders

The brain is often referred to as a "black box" - one that's difficult to peer inside and determine what's happening at any given moment.

20 May 2024

Fruit fly wing development offers clues to possible treatments for birth defects

If fruit fly wings do not develop into the right shape, the flies will die. UC Riverside researchers have learned how fly embryo cells develop as they need to, opening a window into human development and possible treatments for birth defects.

17 May 2024

New rule of biology highlights benefits of instability in living organisms

A molecular biologist at the USC Dornsife College of Letters, Arts and Sciences may have found a new "rule of biology."

17 May 2024

Genes and age reveal new insights into cognitive variability, study finds

Study examines the effects of specific genes and age on cognition, revealing potential for creating genotype- and cognition-stratified cohorts for future research.

16 May 2024

Azenta opens the doors to its new genomics laboratory in Oxford, UK

Azenta, Inc. today announced the grand opening of the new Genomics Laboratory in Oxford, UK, expanding its global reach of GENEWIZ Multiomics & Synthesis Solutions further in the UK market.

From Azenta Life Sciences 16 May 2024

Study reveals CNTN4 gene's role in neuronal development and Alzheimer's disease pathogenesis

New research has shed light on the complex interplay between cell proteins, and how they impact on neurons in neurodevelopmental disorders and Alzheimer's disease.

15 May 2024