Genomics

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Novel assay enhances pediatric cancer treatment by identifying clinically relevant gene fusions

Identification of specific gene fusions is critical for the successful targeted treatment of pediatric cancer patients.

13 Feb 2024

Gene editing gets a boost with new CRISPR-COPIES

CRISPR/Cas systems have undergone tremendous advancement in the past decade. These precise genome editing tools have applications ranging from transgenic crop development to gene therapy and beyond.

12 Feb 2024

Understanding how natural genetic variation contributes to adaptive responses to low oxygen

Humans are still evolving, and Tatum Simonson, PhD, founder and co-director of the Center for Physiological Genomics of Low Oxygen at University of California School of Medicine, plans to use evolution to improve healthcare for all.

12 Feb 2024

Breakthrough technique unveils secrets of "backtracking" in gene regulation

A technique can determine for the first time how frequently, and exactly where, a molecular event called "backtracking" occurs throughout the genetic material (genome) of any species, a new study shows.

9 Feb 2024

DDT exposure found to alter sperm epigenome in humans

In a study that signals potential reproductive and health complications in humans, now and for future generations, researchers from McGill University, the University of Pretoria, Université Laval, Aarhus University, and the University of Copenhagen, have concluded that fathers exposed to environmental toxins, notably DDT, may produce sperm with health consequences for their children.

9 Feb 2024

Decoding the differences between two vital RNA transport complexes

Genetic expression, often leading to protein synthesis, requires a complex coordination of molecular machinery across several stages.

8 Feb 2024

Never-before-documented genetic disorder causes rare lung disease

The macrophage is one of the body's most important inhabitants. Meaning "big eater" in Greek, this immune cell consumes and digests problematic elements from microbes and cancer cells to dust and debris.

8 Feb 2024

Parental traits offer new clues to predicting neurodevelopmental disorders in children

Predicting the trajectory of neurodevelopmental and psychiatric disorders like autism or schizophrenia is difficult because they can be influenced by many different genetic and environmental factors.

8 Feb 2024

Researchers develop new approach to improve the accuracy of RNA sequencing

A team at NDORMS, University of Oxford has developed a new approach to significantly improve the accuracy of RNA sequencing.

7 Feb 2024

Extra fingers and double hearts: Scientists decode how tiny mutations can derail development

Our genomes provide the instructions for proper growth and development. Millions of genomic switches, known as enhancers, control the location and timing of gene expression, which in turn ensures the correct proteins are made in the right cells at the right time throughout our lives.

6 Feb 2024

Researchers discover mechanism that protects tissue after faulty gene expression

The genetic material, in the form of DNA, contains the information that is crucial for the correct functioning of every human and animal cell.

2 Feb 2024

CRISPR-Cas9 gene-editing tool repairs defective T cells to treat rare hereditary disease

Some hereditary genetic defects cause an exaggerated immune response that can be fatal. Using the CRISPR-Cas9 gene-editing tool, such defects can be corrected, thus normalizing the immune response, as researchers led by Klaus Rajewsky from the Max Delbrück Center now report in "Science Immunology."

2 Feb 2024

Breakthrough recombinase technology ushers in precise, adaptable gene editing

A team of researchers at the Carl Gustav Carus Faculty of Medicine, TUD Dresden University of Technology, led by Prof. Frank Buchholz, has achieved a major breakthrough in genome editing technology.

1 Feb 2024

CRISPR revolutionized: New method edits genes directly in the body

Most approved gene therapies today, including those involving CRISPR-Cas9, work their magic on cells removed from the body, after which the edited cells are returned to the patient.

1 Feb 2024

Ancient genomes unearth degenerate transposable elements in human DNA

The human genome, an intricate tapestry of genetic information for life, has proven to be a treasure trove of strange features. Among them are segments of DNA that can "jump around" and move within the genome, known as "transposable elements" (TEs).

30 Jan 2024

Study unmasks secrets of glioma's invasive margins

High-grade gliomas are cancerous tumors that spread quickly in the brain or spinal cord.

30 Jan 2024

RNA sequencing analysis feasible for diagnosis of molecular subtypes in pediatric B-ALL

Acute lymphoblastic leukemia (ALL) is the most common childhood cancer, representing more than 30% of all pediatric cases.

29 Jan 2024

Gene variant linked to increased miscarriage risk through disrupted chromosome pairing

Scientists at deCODE genetics, a subsidiary of Amgen and their collaborators from Iceland, Denmark and USA published a study today in Nature Structural and Molecular Biology titled "Variant in the synaptonemal complex protein SYCE2 associates with pregnancy loss through effects on recombination".

29 Jan 2024

HIV virus found to possess hidden transport ability

Around one million individuals worldwide become infected with HIV, the virus that causes AIDS, each year.

27 Jan 2024

Mutation butterfly effect: Study reveals how single change triggers autism gene network

Researchers in the RIKEN Center for Brain Science (CBS) examined the genetics of autism spectrum disorder (ASD) by analyzing mutations in the genomes of individuals and their families.

27 Jan 2024

Genomics

Novel assay enhances pediatric cancer treatment by identifying clinically relevant gene fusions

Gene editing gets a boost with new CRISPR-COPIES

Understanding how natural genetic variation contributes to adaptive responses to low oxygen

Breakthrough technique unveils secrets of "backtracking" in gene regulation

DDT exposure found to alter sperm epigenome in humans

Decoding the differences between two vital RNA transport complexes

Never-before-documented genetic disorder causes rare lung disease

Parental traits offer new clues to predicting neurodevelopmental disorders in children

Researchers develop new approach to improve the accuracy of RNA sequencing

Extra fingers and double hearts: Scientists decode how tiny mutations can derail development

Researchers discover mechanism that protects tissue after faulty gene expression

CRISPR-Cas9 gene-editing tool repairs defective T cells to treat rare hereditary disease

Breakthrough recombinase technology ushers in precise, adaptable gene editing

CRISPR revolutionized: New method edits genes directly in the body

Ancient genomes unearth degenerate transposable elements in human DNA

Study unmasks secrets of glioma's invasive margins

RNA sequencing analysis feasible for diagnosis of molecular subtypes in pediatric B-ALL

Gene variant linked to increased miscarriage risk through disrupted chromosome pairing

HIV virus found to possess hidden transport ability

Mutation butterfly effect: Study reveals how single change triggers autism gene network

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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