Genomics

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New USC study reveals how DNA loops silence gene activity

The blueprint for human life lies within the DNA in the nucleus of each of our cells. In human cells, around six and a half feet of this genetic material must be condensed to fit inside the nucleus. DNA condensation is not random.

16 Jan 2024

Pioneering Genomic Progress: An Interview with Rami Mehio, Illumina's Software and Informatics Expert

In this interview, Rami Mehio, head of software and informatics at Illumina, shares his experiences and contributions to major genomic projects like the UK Biobank's whole genome sequencing. He discusses the challenges and innovations in genomic data analysis, highlighting Illumina's role in advancing genetic research and precision medicine.

From Illumina, Inc. 15 Jan 2024

Ancient genomes reveal origins of multiple sclerosis risk in Europe

Researchers investigated the variables contributing to geographical heterogeneity in multiple sclerosis prevalence and the impact of genetic and environmental factors on the disease's development.

15 Jan 2024

Community health workers champion genetic literacy for minorities

Changes to DNA, known as mutations, can increase the likelihood of developing cancer. Specifically, people with mutations in their BRCA 1 and 2 genes are substantially more likely to develop hereditary breast and ovarian cancers. But how do people know if they have these mutations?

12 Jan 2024

Paternal sperm microRNAs also play a role in offspring health

A recent study has reported that changes in mice sperm microRNAs brought about by aging may affect the growth and development of offspring.

12 Jan 2024

Drug-resistant Candida: Study uncovers evolutionary tricks of a fungal pathogen

Global fungal infections, which affect one billion people and cause 1.5 million deaths each year, are on the rise due to the increasing number of medical treatments that heighten vulnerability.

12 Jan 2024

Scientists develop noninvasive way to monitor gene expression dynamics in the brain

Researchers introduced a non-invasive, sensitive method for monitoring gene expression in the brain using engineered reporters called released markers of activity, which can exit the brain into the blood for easy detection.

12 Jan 2024

Revolutionary blood test monitors gene expression dynamics in the brain

The brain is the most protected organ in the body, sheathed in a complex and nearly impenetrable barrier of specialized blood vessels.

11 Jan 2024

Study shows how cancer care can be transformed from 'one size fits all' approach into precision healthcare

In the largest study of its kind, scientists today report how combining health data with whole genome sequence (WGS) data in patients with cancer can help doctors provide more tailored care for their patients.

10 Jan 2024

Study identifies more than 200 new genes linked to depression

More than 200 genes linked to depression have been newly identified in a worldwide study led by UCL researchers.

10 Jan 2024

Unearthing individual-level mutation risk patterns

Mutations, which occur continuously in every cell of our bodies, are a key contributor to cancer, ageing, and neurodegeneration.

10 Jan 2024

Breakthrough in gene editing: Enhanced virus-like particles promise new era in genetic disease treatment

Researchers developed an advanced prime editor-engineered virus-like particle (PE-eVLP) system, significantly enhancing gene editing efficiency in human cells and showing potential for treating genetic diseases.

9 Jan 2024

CRISPR cures on the horizon: Breakthrough center aims to heal rare, deadly genetic diseases

Children and adults with rare, deadly genetic diseases have fresh hope for curative therapies, thanks to a new collaboration between the Innovative Genomics Institute (IGI) and Danaher Corporation, a global life sciences and diagnostics innovator.

9 Jan 2024

Engineered virus-like particles power up gene editing, correcting blindness in mice

Prime editing, a versatile form of gene editing that can correct most known disease-causing genetic mutations, now has a new vehicle to deliver its machinery into cells in living animals.

8 Jan 2024

Genomic analysis of uncultured bacteria from patients identifies more than thirty new species

Unknown germs are a common occurrence in hospitals. Researchers at the University of Basel have spent many years collecting and analyzing them.

8 Jan 2024

Study identifies 9 novel genes linked to gestational diabetes

The largest genetic study of gestational diabetes to date has led to a discovery of nine novel genetic regions linked to this severe and common pregnancy complication.

5 Jan 2024

Researchers discover PPFIA3 gene as a cause of previously unknown syndromic neurodevelopmental disorder

An international collaborative study led by postdoctoral scientist, Dr. Maimuna Paul, and child neurologist, Dr. Hsiao-Tuan Chao, an assistant professor at Baylor College, a faculty member with the Cain Pediatric Neurology Research Foundation Laboratories at the Jan and Dan Duncan Neurological Research Institute (Duncan NRI) at Texas Children's Hospital, and an investigator at the McNair Medical Institute with The Robert and Janice McNair Foundation, recently discovered that variants in the PPFIA3 gene cause a previously unknown syndromic neurodevelopmental disorder.

4 Jan 2024

New study highlights the work of biobank at the Colorado Center for Personalized Medicine

A new peer-reviewed study in the American Journal of Human Genetics highlights the work of the biobank at the Colorado Center for Personalized Medicine (CCPM), a world-class site for precision medicine in research and clinical care created in partnership with the University of Colorado Anschutz Medical Campus and UCHealth.

4 Jan 2024

Revolutionary RNA-based switch offers new control over gene expression in mammalian cells

Researchers developed an RNA-based switch, the pA regulator system, to control gene expression in mammalian cells by modulating synthetic polyA signal cleavage, offering a novel approach for gene therapy applications.

4 Jan 2024

"Genetic priority score" promises to revolutionize drug development

Driven by the need for a better way to prioritize targets for drug development, the Icahn School of Medicine at Mount Sinai has led the development of a novel "genetic priority score" (GPS) that will integrate various types of human genetic data into a single easy-to-interpret score.

3 Jan 2024

Genomics

New USC study reveals how DNA loops silence gene activity

Pioneering Genomic Progress: An Interview with Rami Mehio, Illumina's Software and Informatics Expert

Ancient genomes reveal origins of multiple sclerosis risk in Europe

Community health workers champion genetic literacy for minorities

Paternal sperm microRNAs also play a role in offspring health

Drug-resistant Candida: Study uncovers evolutionary tricks of a fungal pathogen

Scientists develop noninvasive way to monitor gene expression dynamics in the brain

Revolutionary blood test monitors gene expression dynamics in the brain

Study shows how cancer care can be transformed from 'one size fits all' approach into precision healthcare

Study identifies more than 200 new genes linked to depression

Unearthing individual-level mutation risk patterns

Breakthrough in gene editing: Enhanced virus-like particles promise new era in genetic disease treatment

CRISPR cures on the horizon: Breakthrough center aims to heal rare, deadly genetic diseases

Engineered virus-like particles power up gene editing, correcting blindness in mice

Genomic analysis of uncultured bacteria from patients identifies more than thirty new species

Study identifies 9 novel genes linked to gestational diabetes

Researchers discover PPFIA3 gene as a cause of previously unknown syndromic neurodevelopmental disorder

New study highlights the work of biobank at the Colorado Center for Personalized Medicine

Revolutionary RNA-based switch offers new control over gene expression in mammalian cells

"Genetic priority score" promises to revolutionize drug development

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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