Genomics

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New AI method predicts gene activity in human cells

Using a new artificial intelligence method, researchers at Columbia University Vagelos College of Physicians and Surgeons can accurately predict the activity of genes within any human cell, essentially revealing the cell's inner mechanisms.

8 Jan 2025

Childhood stress impacts epigenetic profile of sperm and brain development

Childhood stress can impact the epigenetic profile of sperm. These results may also have practical implications for future generations through epigenetic inheritance, as many of the observed epigenetic associations are related to brain development.

8 Jan 2025

UCD researchers discover gene mutation linked to vision problems in zebrafish

Researchers in University College Dublin (UCD) have discovered that a mutation in a gene called emc1 causes major vision problems in zebrafish.

8 Jan 2025

New research reveals potential biomarkers for epilepsy diagnosis

New research led by UTHealth Houston scientists uncovered two genes associated with variants linked to epilepsy, which showed specific traits that make them promising diagnostic biomarkers.

6 Jan 2025

Newly identified genes may hold the key to understanding brain's response to PFAS

Per- and polyfluorinated alkyl substances (PFAS) earn their "forever chemical" moniker by persisting in water, soil and even the human brain.

6 Jan 2025

Bacteria in Lake Mendota evolve in cycles following seasonal shifts

Like Bill Murray in the movie "Groundhog Day," bacteria species in a Wisconsin lake are in a kind of endless loop that they can't seem to shake. Except in this case, it's more like Groundhog Year.

3 Jan 2025

Genetic mutation in esophageal cancer found to have dual effects

A genetic fault long believed to drive the development of esophageal cancer may in fact play a protective role early in the disease, according to new research published in Nature Cancer.

3 Jan 2025

Twigstats unveils Europe’s hidden ancestral shifts from Iron Age to Viking era

Twigstats reveals ancient migrations in Europe, enhancing genomic analysis and uncovering genetic shifts from 500 BCE to 1000 CE with unprecedented precision.

3 Jan 2025

Unveiling the role of gene inactivation in human disease

New work by Columbia researchers has turned a textbook principle of genetics on its head and revealed why some people who carry disease-causing genes experience no symptoms.

2 Jan 2025

Study identifies novel IgAN loci through pleiotropy

IgA nephropathy (IgAN) is a prevalent form of primary glomerulonephritis characterized by the deposition of IgA in the glomerular mesangium, leading to a spectrum of histopathological lesions and a variable clinical course that can progress to end-stage renal disease in a significant proportion of patients.

2 Jan 2025

Study provides new insights into the genetic underpinnings of pediatric cancers

Largescale changes in the genome inherited from parents are significant risk factors for pediatric solid tumors, such as Ewing sarcoma, neuroblastoma, and osteosarcoma, according to a new study.

2 Jan 2025

Scientists launch public resource to classify cancer subtypes for better diagnosis

A multi-institutional team of scientists has developed a free, publicly accessible resource to aid in classification of patient tumor samples based on distinct molecular features identified by The Cancer Genome Atlas (TCGA) Network.

2 Jan 2025

Unraveling retrotransposon mechanisms in centromere insertion

A joint research group team led by Sayuri Tsukahara and Tetsuji Kakutani of the University of Tokyo has clarified a mechanism of how retrotransposons, genetic elements that can "jump around" chromosomes and are known drivers of evolution, preferentially insert in the centromere.

1 Jan 2025

Advancements in DNA storage through epi-bit technology

In the era of big data, global mass data flow has presented data storage systems with a looming challenge. As DNA has incredibly high storage density – a single gram of DNA can store 215,000 terabytes, the same size as 10 million hours of high-definition video (Imburgia & Nivala, 2024)– and long-term stability, it is an attractive medium for data storage.

26 Dec 2024

New method allows non-destructive study of fish teeth

Can we examine the teeth of living fish and other vertebrates in detail, repeatedly over time, without harming them?

26 Dec 2024

Fruit flies steal bacterial defense to survive parasitic wasps

In the continual arms race between parasites and their hosts, innovation was thought to be the key to a successful attack or defense that one-ups the competition.

24 Dec 2024

New insights into the developmental trajectory of social behaviors in fragile X syndrome

In a comprehensive Genomic Press Interview, researchers from the University of Texas Health Science Center at San Antonio and Hirosaki University have uncovered critical new insights into the developmental trajectory of social behaviors in fragile X syndrome, the leading genetic cause of autism spectrum disorder.

24 Dec 2024

SPLICER shows promise in Alzheimer's and other diseases

A new gene editing tool that helps cellular machinery skip parts of genes responsible for diseases has been applied to reduce the formation of amyloid-beta plaque precursors in a mouse model of Alzheimer's disease, researchers at the University of Illinois Urbana-Champaign report.

23 Dec 2024

New synthetic biology breakthrough improves genetic circuit integration

The research team led by Professor Jongmin Kim from the Department of Life Sciences at POSTECH, along with graduate students Hyunseop Goh and Seungdo Choi, has successfully developed the 'Synthetic Translational Coupling Element (SynTCE),' significantly enhancing the precision and integration density of genetic circuits in synthetic biology.

20 Dec 2024

A scaffolded vaccine approach for broader influenza protection

Most people who get the seasonal influenza vaccine – which contains strains of viruses from distinct virus subtypes – mount a strong immune response to one strain, leaving them vulnerable to infection by the others, and researchers have long wondered what impacts such variable responses more – host genetics or prior exposure to virus strains.

19 Dec 2024