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Obe-cel demonstrates strong efficacy and safety in treating leukemia

Patients with relapsed or refractory CD19-positive B-cell acute lymphoblastic leukemia (ALL) who were treated with the novel anti-CD19 chimeric antigen receptor (CAR) T cell therapy, obecabtagene autoleucel (obe-cel), experienced high response rates and most did not need a subsequent stem cell transplant (SCT), according to results from the Phase Ib/II FELIX trial co-led by researchers at The University of Texas MD Anderson Cancer Center.

27 Nov 2024

Study links combined risk factors for aggressive behavior in men with CTE

People who have chronic traumatic encephalopathy (CTE) who have a family history of mental illness may have a higher risk of aggression in middle age, according to a study published in the November 27, 2024, online issue of Neurology®, the medical journal of the American Academy of Neurology.

27 Nov 2024

CBT and rehabilitation likely to improve long covid symptoms

Cognitive behavioral therapy (CBT) and a program of physical and mental rehabilitation probably improve symptoms of long covid, but the effects are modest, finds a review of the latest evidence published by The BMJ today.

27 Nov 2024

Targeting intracellular checkpoints to enhance NK cell immunotherapy

Natural killer (NK) cells are pivotal in the innate immune response against cancer and viral infections, with their presence in tumors correlating to better patient outcomes in various cancers.

27 Nov 2024

Persistence landscapes could help achieve unbiased and accurate radiological interpretation

A new editorial was published in Oncotarget's Volume 15 on November 12, 2024, entitled "Persistence landscapes: Charting a path to unbiased radiological interpretation."

27 Nov 2024

New injection treatment could be a game-changer for people with asthma and COPD

An injection given during some asthma and COPD attacks is more effective than the current treatment of steroid tablets, reducing the need for further treatment by 30%.

27 Nov 2024

SONIA trial demonstrates cost-effective treatment approach for advanced breast cancer

On November 27, the prestigious journal Nature will publish the results of an innovative breast cancer research project from the Netherlands.

27 Nov 2024

Understanding the pathophysiological relationship between OSA and metabolic syndrome

Cardiovascular diseases remain a leading cause of mortality globally, particularly among individuals with both obstructive sleep apnea (OSA) and metabolic syndrome (MetS).

27 Nov 2024

Adults with egg white allergy face significant quality of life challenges

Study reveals significant impairments in the quality of life for adults with hen's egg white allergy, highlighting the need for accurate food labeling and further research into effective treatments.

27 Nov 2024

Childhood social disadvantage linked to increased MS severity

People who develop multiple sclerosis (MS) as children and grow up in less advantaged neighborhoods may have a larger volume of inflammation and brain tissue loss on imaging than those who grow up in more advantaged neighborhoods, according to a study published in the November 27, 2024, online issue of Neurology, the medical journal of the American Academy of Neurology.

27 Nov 2024

Novel mRNA-based therapy offers hope for patients with proliferative vitreoretinopathy

A new preclinical study by Mass Eye and Ear investigators showed that a novel mRNA-based therapy may be able to prevent blindness and scarring from proliferative vitreoretinopathy (PVR) following a retinal detachment repair or traumatic injury to the eye.

27 Nov 2024

Stanford team uses natural cell death mechanism to kill cancer cells

Our bodies divest themselves of 60 billion cells every day through a natural process of cell culling and turnover called apoptosis.

27 Nov 2024

Study reveals protein mobility defect as a key factor in chronic diseases

Chronic diseases like type 2 diabetes and inflammatory disorders have a huge impact on humanity. They are a leading cause of disease burden and deaths around the globe, are physically and economically taxing, and the number of people with such diseases is growing.

27 Nov 2024

Research shows "Alzheimer's in a dish" model can accelerate drug discovery

A decade ago, researchers introduced a new model for studying Alzheimer's disease. Known as "Alzheimer's in a dish," the model uses cultures of mature brain cells suspended in a gel to recapitulate what takes place in the human brain over 10 to 13 years in just six weeks.

27 Nov 2024

Younger age at type 2 diabetes diagnosis increases mortality risk

Research found that younger age at type 2 diabetes diagnosis is associated with higher risks of cardiovascular and all-cause mortality, emphasizing the need for early prevention and personalized management strategies.

27 Nov 2024

Philadelphia beverage tax: Did it curb childhood obesity?

The 2017 Philadelphia beverage tax aimed to reduce sugar-sweetened beverage consumption and improve pediatric health. While it significantly reduced sugary drink purchases, its impact on overall pediatric weight was limited, with minor changes observed in specific subgroups.

27 Nov 2024

IQWiG evaluates smoking cessation drugs for severe tobacco dependence treatment

By law, smokers with severe tobacco dependence are entitled to receive one-off drug therapy for smoking cessation as part of evidence-based programmes reimbursed by the German statutory health insurance (SHI).

27 Nov 2024

Study unveils key mechanism in Alzheimer's disease

A new study from the University of Liverpool represents a significant step forward in scientists' understanding of Alzheimer's disease.

27 Nov 2024

Exposure to air pollutants raises risk of persistent long-COVID symptoms

Exposure to air pollutants (PM2.5 and PM10) is associated with an increased risk of persistent long-COVID symptoms, partly due to its impact on the severity of the acute infection.

27 Nov 2024

Social media's role in shaping public attitudes toward obesity

Through an analysis of tweets (now rebranded X) relating to obesity published between April 2019 and December 2022, a study conducted by the Geneva University Hospitals (HUG) and the University of Geneva (UNIGE) has revealed that most of these tweets convey negative sentiments about overweight.

27 Nov 2024