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Lipid buildup predicts weaker bones once it passes a critical threshold

A large cross-sectional study using NHANES data found a non-linear negative relationship between lipid accumulation product (LAP) and lumbar spine bone mineral density (BMD). The association became significant only above a threshold value (ln-LAP > 2.846), independent of BMI.

12 May 2025

Review spotlights MYC as a multidimensional therapeutic target in cancer

A new review in Genes and Diseases explores the central role of MYC, a master regulatory protein, in the development and progression of cancer, spotlighting its potential as a multidimensional therapeutic target.

12 May 2025

Testosterone use not linked to increased gynecological cancer risk in early years

Transmasculine and gender-diverse individuals who use testosterone are not at increased risk of gynecological cancer in the first years of hormone therapy.

12 May 2025

RANBP2 identified as key regulator in the progression of multiple solid tumors

The nuclear pore complex protein RANBP2 has emerged as a critical factor in the development and progression of various solid malignancies.

12 May 2025

Study shows cardiovascular benefits of GLP-1RAs in patients following bariatric surgery

Medications like semaglutide and liraglutide may help to reduce the risk for heart attacks, strokes, and other major adverse cardiovascular events (MACE) as well as death in adults with obesity and diabetes following bariatric surgery who did not achieve sufficient weight loss and diabetes control, according to new research being presented at this year's European Congress on Obesity (ECO) in Malaga, Spain.

12 May 2025

Simple vest could help older adults maintain weight loss long term

Wearing a weighted vest during a 6-month calorie-restricted weight loss program helped older adults with obesity regain less weight over 24 months compared to those on diet alone. This benefit may be due to better preservation of resting metabolic rate during the intervention.

12 May 2025

Mitochondrial DNA editing offers new hope for neurodegenerative disease treatment

Mitochondrial DNA (mtDNA) editing has emerged as a revolutionary approach in the fight against neurodegenerative diseases (NDDs).

12 May 2025

Estrogen-related receptors could be a key to repairing energy metabolism and muscle fatigue

A new Salk Institute study suggests estrogen-related receptors could be a key to repairing energy metabolism and muscle fatigue.

12 May 2025

HER3 reemerges as a key driver of cancer progression and therapy resistance

A new publication shines a spotlight on HER3, a long-overlooked member of the ErbB receptor family, revealing its critical role in cancer progression and resistance to therapy.

12 May 2025

Mice study sheds light on the mechanisms underlying sex differences in psychiatric conditions

Conditions such as Tourette syndrome (TS), schizophrenia, and Attention-Deficit/Hyperactivity Disorder (ADHD) have sex differences with unknown mechanisms.

12 May 2025

Study links gum disease symptoms to higher risk of multiple chronic conditions

A major new study presented at EuroPerio11, the world's leading congress in periodontology and implant dentistry by the EFP, has found that people with signs of gum disease are more likely to suffer from multiple chronic health conditions, a state known as multimorbidity.

12 May 2025

CAR-T cell therapy linked to brain fog in cancer patients

After treatment with CAR-T cells - immune cells engineered to attack cancer - patients sometimes tell their doctors they feel like they have "brain fog," or forgetfulness and difficulty concentrating.

12 May 2025

Tirzepatide outperforms semaglutide for weight loss in people without diabetes

A head-to-head trial found that tirzepatide led to significantly greater weight loss and waist reduction than semaglutide in adults with obesity but without diabetes. Over 72 weeks, tirzepatide helped more participants reach key weight loss milestones, with manageable side effects and strong metabolic benefits.

12 May 2025

Living near golf courses raises Parkinson’s disease risk, study finds

Living within 1 to 3 miles of a golf course is associated with a significantly higher risk of Parkinson’s disease, particularly in groundwater-vulnerable areas. The study suggests both drinking water contamination and airborne pesticides may contribute to elevated risk.

12 May 2025

Chokeberry juice reduces blood vessel resistance in people with pre-diabetes

A German crossover trial found that drinking polyphenol-rich red berry juice improved peripheral resistance and helped preserve muscle mass in pre-diabetic adults. No significant changes were seen in glucose control or oxidative stress over the 14-day interventions.

12 May 2025

Large language models help predict epileptogenic zones for surgery

Epilepsy, one of the most common neurological disorders characterized by recurrent seizures, affects over 70 million people worldwide.

12 May 2025

Novel Alzheimer's therapy shows low risk of severe side effects

The Food and Drug Administration's approval in 2023 of lecanemab - a novel Alzheimer's therapy shown in clinical trials to modestly slow disease progression - was met with enthusiasm by many in the field as it represented the first medication of its kind able to influence the disease.

12 May 2025

Hearing aids may help older adults combat social isolation

Providing hearing aids and advice on their use may preserve social connections that often wane as we age, a new study shows.

12 May 2025

Saving teeth through regeneration offers long-term benefits over implants

A major long-term study presented at EuroPerio11, the world's leading congress on gum health and implant dentistry by the European Federation of Periodontology (EFP), reveals that saving teeth with severe bone loss through periodontal regeneration (PR) offers benefits equal to - if not greater than - replacing them with dental implants or bridges.

12 May 2025