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CU Cancer Center study finds distinct genetic drivers of colorectal cancer in younger and older patients

A University of Colorado Cancer Center study being presented Saturday at the 2016 Genitourinary Cancers Symposium shows genetic differences between colorectal cancer (CRC) in young and old patients, possibly pointing toward different treatments and strategies in combating the young form of the disease.

22 Jan 2016

Study finds possibility of targeting Orai3 as novel treatment for obesity-related inflammation

A new study by a team of Rosalind Franklin University researchers headed by Carl White, PhD, assistant professor of physiology and biophysics, has discovered that the degree of chronic inflammation caused by obesity is highly dependent on levels of the signaling molecule, hydrogen sulfide, which alters the activity of a calcium channel, Orai3.

22 Jan 2016

Researchers use ASC secreted factors to create therapeutic factor concentrate for critical limb ischemia

"Critical limb ischemia" (CLI) describes an advanced stage of peripheral artery disease characterized by obstruction of the arteries and a markedly reduced blood flow to the extremities. CLI identifies patients at high-risk for major amputation. The estimated annual incidence of CLI ranges between 500 and 1000 new cases out of one million people per year, with the highest rates among the elderly, smokers, and those with diabetes. CLI is considered to be a critical public health issue. Attempts at revascularization are often unsuccessful.

22 Jan 2016

UT Southwestern researchers reveal how CDK4/6-inhibitors alter pancreatic cancer cell metabolism

UT Southwestern Medical Center researchers have found that cancer drugs known as CDK4/6-inhibitors alter the metabolism of pancreatic cancer cells, revealing a biologic vulnerability that could be exploited for therapeutic gain.

22 Jan 2016

Bariatric surgery prior to knee replacement benefits morbidly obese patients with end-stage osteoarthritis

Previous research studies have linked obesity to adverse outcomes and increased costs following total knee replacement surgery (TKR). A new, computer model-based evaluation appearing in the Journal of Bone and Joint Surgery, supports bariatric surgery in morbidly obese patients with end-stage osteoarthritis (loss of cartilage and joint pain, caused by aging and use) prior to TKR.

22 Jan 2016

Amgen announces approval of cholesterol-lowering medication Repatha (evolocumab) Injection in Japan

Amgen today announced that the Japanese Ministry of Health, Labour and Welfare has approved the cholesterol-lowering medication Repatha (evolocumab) Injection, the first proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor to be approved in Japan.

22 Jan 2016

Simple blood test could predict relapse in AML patients

A simple blood test capable of detecting trace levels of leukaemia cells remaining after intensive chemotherapy has been developed by scientists at the National Institute for Health Research Biomedical Research Centre at Guy’s and St Thomas’ NHS Foundation Trust and King’s College London.

22 Jan 2016

Aged Garlic Extract beneficial for preventing heart disease

The supplement Aged Garlic Extract can reverse the buildup of deadly plaque in arteries and help prevent the progression of heart disease, according to a new study scheduled for publication in the Journal of Nutrition.

22 Jan 2016

Dartmouth researchers discover rare natural products that promote regeneration of injured nerve cells

Nerve damage from neurodegenerative disease and spinal cord injury has largely been considered irreversible, but Dartmouth researchers report progress in the effort to synthesize rare natural products that promote regeneration and growth of injured nerve cells.

22 Jan 2016

Researchers identify biomarkers that may influence potential new drug design or alternative treatments of cancer

Researchers have discovered gene-targets (biomarkers) that may enable alternative treatments or the potential design of new drugs that target metastasis-promoting tumor genes.

22 Jan 2016

New study identifies DKK3 as a driver of kidney fibrosis

Chronic kidney disease can develop in response to a variety of insults and is characterized by progressive renal fibrosis and atrophy of kidney tubule. Therapeutic options are limited and the disease is often not detected until later stages.

22 Jan 2016

First national PSA campaign launched with strong message: No one is excused from prediabetes

Losing weight and being healthier are at the top of everyone’s New Year’s resolutions. But, despite the best intentions, work, kids, and social events often push lifestyle changes to the bottom of the list.

22 Jan 2016

Fibrosis in kidney transplants driven by continuous injury

Clinically, kidney fibrosis can be used to assess stage, progression, and prognosis for both kidney transplants and kidney disease. There is debate as to whether kidney fibrosis is a maladaptive, injury-triggered process that inherently progresses to kidney failure or an adaptive wound-healing process that stabilizes the injury site.

22 Jan 2016

People suffering from chronic stress, anxiety may be at increased risk for depression and dementia

A scientific review paper warns that people need to find ways to reduce chronic stress and anxiety in their lives or they may be at increased risk for developing depression and even dementia.

22 Jan 2016

Mindfulness could help children avoid obesity

Mindfulness, described as paying attention on purpose and being in the present moment with acceptance, could be an effective way to help children avoid obesity. New research published in the journal Heliyon suggests that the balance in brain networks in children who are obese is different compared to healthy-weight children, making them more prone to over-eating.

22 Jan 2016

Champions Oncology begins prospective correlative trial of PDX in patients with sarcoma

Champions Oncology today announced that it has initiated a sponsored prospective correlative trial of patient derived xenograft modeling (PDX or Champions TumorGraft PDX models) in patients with metastatic or recurrent sarcoma. Mount Sinai Hospital in Toronto, Canada is the first clinical site to enroll patients in the newly-opened study.

21 Jan 2016

Medical Condition News

CU Cancer Center study finds distinct genetic drivers of colorectal cancer in younger and older patients

Study finds possibility of targeting Orai3 as novel treatment for obesity-related inflammation

Researchers use ASC secreted factors to create therapeutic factor concentrate for critical limb ischemia

UT Southwestern researchers reveal how CDK4/6-inhibitors alter pancreatic cancer cell metabolism

Bariatric surgery prior to knee replacement benefits morbidly obese patients with end-stage osteoarthritis

Amgen announces approval of cholesterol-lowering medication Repatha (evolocumab) Injection in Japan

Simple blood test could predict relapse in AML patients

Aged Garlic Extract beneficial for preventing heart disease

Dartmouth researchers discover rare natural products that promote regeneration of injured nerve cells

Researchers identify biomarkers that may influence potential new drug design or alternative treatments of cancer

New study identifies DKK3 as a driver of kidney fibrosis

First national PSA campaign launched with strong message: No one is excused from prediabetes

Fibrosis in kidney transplants driven by continuous injury

People suffering from chronic stress, anxiety may be at increased risk for depression and dementia

Mindfulness could help children avoid obesity

Champions Oncology begins prospective correlative trial of PDX in patients with sarcoma

Oxeia accelerating development of neurometabolic treatments for concussions

Paradigm, UnitedHealthcare sign contractual agreement for coverage of PCDx

AbbVie doses first subject in adalimumab clinical trial using Halozyme's ENHANZE technology

MD Anderson and AbbVie join forces to design new immunotherapy cancer patients

Advancing Motor Neuron Disease Diagnosis with Non-Invasive Ultrasound and AI

How agentic AI is reshaping laboratory workflows

Fourier 80: bringing benchtop NMR systems to the laboratory

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