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Investigational stem cell therapy improves outcomes in patients with severe heart failure

An investigational stem cell therapy derived from patients' own blood marrow significantly improved outcomes in patients with severe heart failure, according to a study from the Cedars-Sinai Heart Institute.

5 Apr 2016

Tests used for diagnosing heart disease appear to function differently for women and men

Tests used to diagnose and assess the severity of coronary artery disease appear to function differently for women and men who have stable symptoms, according to researchers from Duke Clinical Research Institute.

5 Apr 2016

Surgery better than widely used drugs for treating hyperparathyroidism

While most cases of osteoporosis are caused by normal aging, another leading cause of the bone-loss disease is a condition called hyperparathyroidism, in which the parathyroid glands release an excessive amount of a hormone that regulates the body's calcium levels.

5 Apr 2016

Very few patients use FDA-approved medications for weight loss, new study suggests

Despite guidelines that advocate the use of weight loss medications to treat obesity, and the availability of FDA approved medications, very few patients use this treatment option, a new study suggests. The results will be presented Sunday, April 3, at ENDO 2016, the annual meeting of the Endocrine Society, in Boston.

5 Apr 2016

Edema Guard Monitor appears to reduce heart failure-related hospitalizations by more than half

In patients with heart failure, use of an investigational device that monitors the accumulation of fluid in the lungs appeared to cut heart failure-related hospitalizations by more than half, meeting the study's primary endpoint, and reduced deaths from any cause by 39 percent per year compared with standard assessment and treatment, researchers reported at the American College of Cardiology's 65th Annual Scientific Session.

5 Apr 2016

Inhalable form of Ambrisentan drug could offer faster-acting treatment option for pulmonary edema

In a new study, researchers show an aerosolized, inhalable form of the drug Ambrisentan could offer a faster-acting treatment option for pulmonary edema, a life-threatening condition in which fluid accumulates in the lungs. Pulmonary edema is a significant risk for anyone spending time at high altitudes, and also affects people with chronic conditions including congestive heart failure and sickle cell anemia.

5 Apr 2016

Blocking blood supply of small cell lung cancer tumors may help delay cancer relapse

A study by researchers at Marshall University Joan C. Edwards School of Medicine has found that blocking the blood supply of small cell lung cancer tumors may help reduce their growth and delay the regrowth process after treatment. Small cell lung cancer is considered the most lethal of all lung cancers.

5 Apr 2016

End-stage heart failure patients treated with cell therapy experience fewer cardiac events

End-stage heart failure patients treated with stem cells harvested from their own bone marrow experienced 37 percent fewer cardiac events - including deaths and heart failure hospital admissions - than a placebo-controlled group, according to a new study.

5 Apr 2016

Aged tumor cells in melanoma behave in a different way than younger tumor cells

Cancer risk increases with one's age as accumulated damage to our cells and chronic inflammation occur over time. Now, an international team of scientists led by The Wistar Institute have shown that aged tumor cells in melanoma behave differently than younger tumor cells, according to study results published in the journal Nature.

5 Apr 2016

Study evaluates long-term outcomes of TAVR with SAPIEN 3 in intermediate-risk patients

To account for baseline differences, TAVR patients were compared by a propensity score analysis with patients randomized to receive surgical intervention in a precursor study, PARTNER 2A. Propensity scoring analysis is a statistical technique used to reduce bias from potential confounding variables, which in this case was used to identify surgical patients from a previous study who would be comparable to TAVR patients in this study.

4 Apr 2016

Magnesium could be safe, cost-effective therapeutic intervention for genetic coagulation disorder

An international team of scientists was able to demonstrate in mouse and patient studies, how magnesium affects the production of blood platelets and that the TRPM7 channel function plays a key role in this process. Scientists of the Rudolf Virchow Center and the Hospital of the University of Würzburg were primarily involved in this study. Their results were published in the current journal "Nature Communications".

4 Apr 2016

Ischemic postconditioning for STEMI patients shows no clinical outcomes

A large randomized controlled trial of ischemic postconditioning in patients who had experienced the deadliest form of heart attack—ST-segment elevation myocardial infarction (STEMI)—failed to show that this procedure significantly reduces death from any cause or hospitalization for heart failure, according to research presented at the American College of Cardiology's 65th Annual Scientific Session.

4 Apr 2016

New CWRU study identifies three glycosyltransferases as major mutational targets in colorectal cancer

Little is known about the molecular basis of aberrant protein glycosylation, a complex enzymatic process that is a hallmark of many human cancers including colorectal cancers (CRC), and how it may contribute to tumor progression. In a new study published in Scientific Reports, an online journal of the Nature Publishing Group, scientists at Case Western Reserve University School of Medicine have successfully characterized the mutational landscapes of glycosylation-associated genes in colon cancer, identifying three glycosyltransferases as significant mutational targets in CRC.

4 Apr 2016

Society of Interventional Radiology honors outstanding achievers with annual awards

Renan Uflacker, M.D., FSIR, was honored posthumously on April 3 with the Society of Interventional Radiology Foundation Leaders in Innovation Award. The award was announced during the Society of Interventional Radiology's Annual Scientific Meeting in Vancouver, British Columbia.

4 Apr 2016

Evolocumab could be more effective than ezetimibe in lowering cholesterol in statin-intolerant patients

In the first major trial of its kind, Cleveland Clinic researchers used a blinded rechallenge with atorvastatin or placebo to objectively confirm the presence of muscle-related symptoms in patients with a history of intolerance to multiple statins and found that evolocumab (a PCSK9 inhibitor) was a more effective option to lower cholesterol than ezetimibe in these patients.

4 Apr 2016

MedUni Vienna researchers identify reason for chemoresistance in small cell lung cancer

Small cell lung cancer is not usually detected until it is at an advanced stage, when metastases have already formed. Chemotherapy is very effective initially but, within a year, cancer recurs and this time does not respond to a course of chemotherapy. The research group headed by Gerhard Hamilton, University Department of Surgery at MedUni Vienna, has now managed to identify the reason for this chemoresistance.

4 Apr 2016

Intravenous beta blockers offer no clinical benefit to patients with STEMI

Giving intravenous beta blockers before performing a coronary angioplasty in patients who had experienced the deadliest form of heart attack—ST-segment elevation myocardial infarction (STEMI)—was safe but did not reduce heart attack severity or improve blood flow from the heart's main pumping chamber, according to research presented at the American College of Cardiology's 65th Annual Scientific Session.

4 Apr 2016

Bariatric arterial embolization safe, effective in sustaining weight loss in severely obese people

Findings from the early phase of a clinical trial led by Johns Hopkins investigators indicates that a new, minimally invasive weight loss treatment known as bariatric arterial embolization is safe and effective in sustaining weight loss in severely obese people.

4 Apr 2016

Increased consumption of antibiotics in childhood may lead to adolescent prediabetes

Young children who take antibiotics may disrupt their gut's microbial ecosystem and be more likely to develop prediabetes in adolescence, new research from Greece reports. The study results will be presented in a poster Sunday, April 3, at ENDO 2016, the annual meeting of the Endocrine Society, in Boston.

4 Apr 2016

Oral Salmonella-based vaccine could prevent Type 1 diabetes

A combined vaccine therapy including live Salmonella is a safe and effective way to prevent diabetes in mice and may point to future human therapies, a new study finds. The results will be on Sunday, April 3, at ENDO 2016, the annual meeting of the Endocrine Society, in Boston.

4 Apr 2016

Medical Condition News

Investigational stem cell therapy improves outcomes in patients with severe heart failure

Tests used for diagnosing heart disease appear to function differently for women and men

Surgery better than widely used drugs for treating hyperparathyroidism

Very few patients use FDA-approved medications for weight loss, new study suggests

Edema Guard Monitor appears to reduce heart failure-related hospitalizations by more than half

Inhalable form of Ambrisentan drug could offer faster-acting treatment option for pulmonary edema

Blocking blood supply of small cell lung cancer tumors may help delay cancer relapse

End-stage heart failure patients treated with cell therapy experience fewer cardiac events

Aged tumor cells in melanoma behave in a different way than younger tumor cells

Study evaluates long-term outcomes of TAVR with SAPIEN 3 in intermediate-risk patients

Magnesium could be safe, cost-effective therapeutic intervention for genetic coagulation disorder

Ischemic postconditioning for STEMI patients shows no clinical outcomes

New CWRU study identifies three glycosyltransferases as major mutational targets in colorectal cancer

Society of Interventional Radiology honors outstanding achievers with annual awards

Evolocumab could be more effective than ezetimibe in lowering cholesterol in statin-intolerant patients

MedUni Vienna researchers identify reason for chemoresistance in small cell lung cancer

Intravenous beta blockers offer no clinical benefit to patients with STEMI

Bariatric arterial embolization safe, effective in sustaining weight loss in severely obese people

Increased consumption of antibiotics in childhood may lead to adolescent prediabetes

Oral Salmonella-based vaccine could prevent Type 1 diabetes

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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