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Study shows mechanistic link between sleep loss in early life and adult behavior in animal model

Mom always said you need your sleep, and it turns out, she was right. According to a new study published in Science this week from researchers at the Perelman School of Medicine at the University of Pennsylvania, lack of sleep in young fruit flies profoundly diminishes their ability to do one thing they do really, really well - make more flies.

22 Apr 2014

Researchers uncover novel function of Amyloid Precursor Protein linked to Alzheimer's disease

A research team led by the National Neuroscience Institute has uncovered a novel function of the Amyloid Precursor Protein (APP), one of the main pathogenic culprits of Alzheimer's disease. This discovery may help researchers understand how the protein goes awry in the brains of Alzheimer's disease patients, and potentially paves the way for the development of innovative therapeutics to improve the brain function of dementia patients.

22 Apr 2014

California Orthopaedic Medical Clinic offers comprehensive surgical solution for spinal stenosis

Like any back surgery, spinal stenosis treatment can be a significant and emotionally taxing moment in a person's life – which is why it is essential to ensure that it is effective the first time by trusting treatment to experts like Dr. Seyed M. Rezaian.

22 Apr 2014

New genetic evidence strengthens link between role of dietary fats with colon cancer progression

Scientists have shown new genetic evidence that could strengthen the link between the role of dietary fats with colon cancer progression.

22 Apr 2014

FDA approves molecularly targeted drug as second-line treatment for advanced stomach cancer

Based on results of a clinical trial led by Dana-Farber Cancer Institute scientists, the U.S. Food and Drug Administration approved a molecularly targeted drug as second-line treatment in advanced stomach cancer that has progressed after standard chemotherapy has failed.

22 Apr 2014

New approach may help reduce use of antipsychotics and other psychiatric drugs in dementia patients

A new approach to handling agitation, aggression and other unwanted behaviors by people with dementia may help reduce the use of antipsychotics and other psychiatric drugs in this population, and make life easier for them and their caregivers, a team of experts says.

22 Apr 2014

Researchers develop simple assay that reveals evolutionary relationships among various tumor sites within patient

The process of metastasis - a tumor's ability to spread to other parts of the body - is still poorly understood. It is not easy to determine whether metastasis began early or late in the development of the primary tumor or whether individual metastatic sites were seeded directly from the original tumor or from an intermediate site.

22 Apr 2014

Small gene embedded in large gene contributes to development of acute myeloid leukemia

A small gene that is embedded in a larger, well-known gene is the true leukemia-promoting force usually attributed to the larger gene, according to a new study by researchers at The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC - James).

22 Apr 2014

Synageva announces publication of LAL Deficiency review in Atherosclerosis

Synageva BioPharma Corp., a biopharmaceutical company developing therapeutic products for rare diseases, today announced the publication of an overview of lysosomal acid lipase deficiency (LAL Deficiency) in the online version and an upcoming print edition of Atherosclerosis, the official journal of the European Atherosclerosis Society.

21 Apr 2014

Study points to new therapeutic strategy for treating depression

A new study points to a conceptually novel therapeutic strategy for treating depression. Instead of dampening neuron firing found with stress-induced depression, researchers demonstrated for the first time that further activating these neurons opens a new avenue to mimic and promote natural resilience.

21 Apr 2014

Sarepta Therapeutics plans to submit eteplirsen NDA for treatment of Duchenne muscular dystrophy

Sarepta Therapeutics, Inc., a developer of innovative RNA-based therapeutics, today announced it plans to submit a New Drug Application (NDA) to the U.S. Food and Drug Administration by the end of 2014 for the approval of eteplirsen for the treatment of Duchenne muscular dystrophy (DMD).

21 Apr 2014

New hypothesis about emergence of Parkinson's disease

The cause of neuronal death in Parkinson's disease is still unknown, but a new study proposes that neurons may be mistaken for foreign invaders and killed by the person's own immune system, similar to the way autoimmune diseases like type I diabetes, celiac disease, and multiple sclerosis attack the body's cells.

21 Apr 2014

FDA and EC grant Orphan Drug Designation to Boehringer’s volasertib for acute myeloid leukemia

Boehringer Ingelheim Pharmaceuticals, Inc. announced today that the U.S. Food and Drug Administration (FDA) and European Commission (EC) have granted Orphan Drug Designation to volasertib for acute myeloid leukemia (AML).

21 Apr 2014

Cedars-Sinai nurses screening hospitalized patients for signs of depression

In an effort to identify and treat patients with undiagnosed depression, Cedars-Sinai nurses are screening each hospitalized patient for signs of the illness and for risk factors that could make recoveries harder and longer.

21 Apr 2014

IV-administered ketamine effective in patients with chronic PTSD

For the first time, evidence that a single dose of IV-administered ketamine was associated with the rapid reduction of symptoms of post-traumatic stress disorder in patients with chronic PTSD was demonstrated in a proof-of-concept, randomized, double blind crossover study, undertaken by researchers at the Icahn School of Medicine at Mount Sinai in New York City. These findings, according to Mount Sinai researchers, could be the first step toward developing new interventions for PTSD.

21 Apr 2014

Genmab/GSK receive FDA sBLA approval for Arzerra in combination with chlorambucil for treatment of CLL

GlaxoSmithKline plc and Genmab A/S announced today that the U.S. Food and Drug Administration (FDA) has approved a Supplemental Biologic License Application (sBLA) for the use of Arzerra® (ofatumumab), a CD20-directed cytolytic monoclonal antibody, in combination with chlorambucil for the treatment of previously untreated patients with chronic lymphocytic leukaemia (CLL) for whom fludarabine-based therapy is considered inappropriate.

21 Apr 2014

Genoa Pharmaceuticals, McMaster University report additional benefits of GP-101 for IPF patients

Genoa Pharmaceuticals, the leader in inhaled medicines for pulmonary fibrosis, and collaborators Drs. Martin Kolb and Kjetil Ask at McMaster University announced today additional measured advantages of inhaled GP-101 (aerosol pirfenidone) in the treatment of idiopathic pulmonary fibrosis (IPF).

21 Apr 2014

India's shocking rates of suicide are highest in areas with most debt-ridden farmers

A new study has found that India's shocking rates of suicide are highest in areas with the most debt-ridden farmers who are clinging to tiny smallholdings - less than one hectare - and trying to grow 'cash crops', such as cotton and coffee, that are highly susceptible to global price fluctuations.

21 Apr 2014

Study sheds light on tiny environments that stem cells occupy in animal bodies

Johns Hopkins researchers have discovered an unexpected phenomenon in the organs that produce sperm in fruit flies: When a certain kind of stem cell is killed off experimentally, another group of non-stem cells can come out of retirement to replace them.

21 Apr 2014

Benzodiazepines may contribute to respiratory problems in people with COPD

A group of drugs commonly prescribed for insomnia, anxiety and breathing issues "significantly increase the risk" that older people with chronic obstructive pulmonary disease, or COPD, need to visit a doctor or Emergency Department for respiratory reasons, new research has found.

21 Apr 2014

Medical Condition News

Study shows mechanistic link between sleep loss in early life and adult behavior in animal model

Researchers uncover novel function of Amyloid Precursor Protein linked to Alzheimer's disease

California Orthopaedic Medical Clinic offers comprehensive surgical solution for spinal stenosis

New genetic evidence strengthens link between role of dietary fats with colon cancer progression

FDA approves molecularly targeted drug as second-line treatment for advanced stomach cancer

New approach may help reduce use of antipsychotics and other psychiatric drugs in dementia patients

Researchers develop simple assay that reveals evolutionary relationships among various tumor sites within patient

Small gene embedded in large gene contributes to development of acute myeloid leukemia

Synageva announces publication of LAL Deficiency review in Atherosclerosis

Study points to new therapeutic strategy for treating depression

Sarepta Therapeutics plans to submit eteplirsen NDA for treatment of Duchenne muscular dystrophy

New hypothesis about emergence of Parkinson's disease

FDA and EC grant Orphan Drug Designation to Boehringer’s volasertib for acute myeloid leukemia

Cedars-Sinai nurses screening hospitalized patients for signs of depression

IV-administered ketamine effective in patients with chronic PTSD

Genmab/GSK receive FDA sBLA approval for Arzerra in combination with chlorambucil for treatment of CLL

Genoa Pharmaceuticals, McMaster University report additional benefits of GP-101 for IPF patients

India's shocking rates of suicide are highest in areas with most debt-ridden farmers

Study sheds light on tiny environments that stem cells occupy in animal bodies

Benzodiazepines may contribute to respiratory problems in people with COPD

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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