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Manchester scientists treat fatal genetic brain disease using stem cell gene therapy

Scientists from The University of Manchester have used stem cell gene therapy to treat a fatal genetic brain disease in mice for the first time.

From The University of Manchester 25 Jul 2013

Randomized trial examines purging of tumor cells from stem cells prior to transplantation in neuroblastoma patients

Judith Villablanca, MD, of The Saban Research Institute of Children's Hospital Los Angeles, Susan Kreissman, MD, of Duke University Medical Center, and colleagues reported the results of a randomized, phase 3 clinical trial conducted by the Children's Oncology Group examining the effect of selectively removing (purging) tumor cells from blood stem cells before they are transplanted back into patients with high-risk neuroblastoma following high-dose chemotherapy.

25 Jul 2013

Real-time monitoring helps ease prosthetic leg pain

University of Washington engineers aim to ease this discomfort with research that could help build better sockets. They have developed a device that tracks how much a person's limb swells and shrinks when inside a prosthetic socket. The data could help doctors and patients predict how and when their limbs will swell, which could be used to build smarter sockets.

25 Jul 2013

GW professor receives $747,000 grant to research causes of severe intellectual disability and autism

As part of a national focus to better understand child health and development, Chiara Manzini, Ph.D., assistant professor of pharmacology and physiology at the George Washington University School of Medicine and Health Sciences, was awarded a $747,000 grant to research the causes of severe intellectual disability and autism.

25 Jul 2013

Stem cell-based epilepsy approach may help in search for better medicines to treat seizure disorders

A new stem cell-based approach to studying epilepsy has yielded a surprising discovery about what causes one form of the disease, and may help in the search for better medicines to treat all kinds of seizure disorders.

25 Jul 2013

Researchers find that Notch signaling elevated in tumors relative to normal bone

Many cancers show inappropriate activation of a cell signaling pathway called NOTCH. In the developing body, NOTCH tells brain cells to grow and proliferate. It should be quiet in the adult body, but cancers restart NOTCH to drive their own growth, far and beyond the rate of healthy tissues.

25 Jul 2013

Mda-9/syntenin helps regulate bladder cancer growth and metastasis

Scientists from Virginia Commonwealth University Massey Cancer Center have provided evidence from preclinical experiments that a gene known as melanoma differentiation associated gene-9/syntenin (mda-9/syntenin) could be used as a therapeutic target to kill bladder cancer cells, help prevent metastasis and even be used to non-invasively diagnose the disease and monitor its progression.

25 Jul 2013

Discovery could lead to new therapeutic strategy for Parkinson's disease

Biologists at The Scripps Research Institute (TSRI) have made a significant discovery that could lead to a new therapeutic strategy for Parkinson's disease.

25 Jul 2013

Study: Heart disease emerges as number one killer among Indians

Heart disease has emerged as the number one killer among Indians, according to a recent study by the Registrar General of India ( RGI) and the Indian Council of Medical Research (ICMR).

25 Jul 2013

Nearly 1/2 of older adults undergoing surgery with general anesthesia have delirium in PACU

Close to half of older adults undergoing surgery with general anesthesia are found to have delirium in the postanesthesia care unit (PACU), according to a study in the August issue of Anesthesia & Analgesia, official journal of the International Anesthesia Research Society (IARS).

25 Jul 2013

Researchers identify key molecular pathways that lead to late-onset Alzheimer's disease

Key molecular pathways that ultimately lead to late-onset Alzheimer's disease, the most common form of the disorder, have been identified by researchers at Columbia University Medical Center (CUMC).

25 Jul 2013

Scientists identify new genetic mutations that can cause pulmonary arterial hypertension

Columbia University Medical Center (CUMC) scientists have identified new genetic mutations that can cause pulmonary arterial hypertension (PAH), a rare fatal disease characterized by high blood pressure in the lungs.

25 Jul 2013

New quantitative screening method for diagnosing and longitudinal tracking of autism in children

Researchers at Indiana University School of Medicine and Rutgers University have developed a new quantitative screening method for diagnosing and longitudinal tracking of autism in children after age 3.

25 Jul 2013

Faulty genetic pathway is a potent player in many types of allergies, say researchers

Newly published research by investigators at the Johns Hopkins Children's Center and the Johns Hopkins Institute of Genetic Medicine reveals that a faulty genetic pathway already known for its role in some connective tissue disorders is also a potent player in many types of allergies.

25 Jul 2013

Stopping cholesterol drugs may increase risk of Parkinson's disease

People who stop taking cholesterol drugs may be at an increased risk for developing Parkinson's disease, according to research that appears in the July 24, 2013, online issue of Neurology, the medical journal of the American Academy of Neurology.

25 Jul 2013

New clinic focuses on men with fast-growing prostate cancer

While every year about 30,000 men die of prostate cancer in the United States, the most common cause of death in men with prostate cancer is heart disease. That's because not all prostate cancers are the same. Some are slow-growing while others are very aggressive.

25 Jul 2013

National Parkinson Foundation releases Parkinson's Central app

The National Parkinson Foundation launched today Parkinson's Central, a free app specifically created for people living with Parkinson's disease and their families. This is the only comprehensive app for people living with Parkinson's.

24 Jul 2013

Ligand Pharmaceuticals, Ethicor Pharma sign license agreement for lasofoxifene

Ligand Pharmaceuticals Incorporated announces the signing of a license agreement with Ethicor Pharma Ltd. for the manufacture and distribution of the oral formulation of lasofoxifene in the European Economic Area, Switzerland and the Indian Subcontinent.

24 Jul 2013

Verastem's defactinib gets FDA orphan drug designation for treatment of mesothelioma

Verastem, Inc., focused on discovering and developing drugs to treat cancer by the targeted killing of cancer stem cells, announced that lead cancer stem cell inhibitor, VS-6063 (defactinib), has received orphan drug designation from the U.S. Food and Drug Administration for use in the treatment of mesothelioma, a rare form of lung cancer.

24 Jul 2013

JACS reports study on LINX Reflux Management System for GERD treatment

An estimated 1 in 5 U.S. adults suffer from Gastroesophageal Reflux Disease (GERD), a chronic, often progressive disease that can cause debilitating symptoms and in certain cases lead to esophageal cancer.

24 Jul 2013

Medical Condition News

Manchester scientists treat fatal genetic brain disease using stem cell gene therapy

Randomized trial examines purging of tumor cells from stem cells prior to transplantation in neuroblastoma patients

Real-time monitoring helps ease prosthetic leg pain

GW professor receives $747,000 grant to research causes of severe intellectual disability and autism

Stem cell-based epilepsy approach may help in search for better medicines to treat seizure disorders

Researchers find that Notch signaling elevated in tumors relative to normal bone

Mda-9/syntenin helps regulate bladder cancer growth and metastasis

Discovery could lead to new therapeutic strategy for Parkinson's disease

Study: Heart disease emerges as number one killer among Indians

Nearly 1/2 of older adults undergoing surgery with general anesthesia have delirium in PACU

Researchers identify key molecular pathways that lead to late-onset Alzheimer's disease

Scientists identify new genetic mutations that can cause pulmonary arterial hypertension

New quantitative screening method for diagnosing and longitudinal tracking of autism in children

Faulty genetic pathway is a potent player in many types of allergies, say researchers

Stopping cholesterol drugs may increase risk of Parkinson's disease

New clinic focuses on men with fast-growing prostate cancer

National Parkinson Foundation releases Parkinson's Central app

Ligand Pharmaceuticals, Ethicor Pharma sign license agreement for lasofoxifene

Verastem's defactinib gets FDA orphan drug designation for treatment of mesothelioma

JACS reports study on LINX Reflux Management System for GERD treatment

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