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First-ever study to evaluate effects of interaction between metamphetamines and Ibudilast

John W. Tsuang, M.D., principal investigator at the Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (LA BioMed), in conjunction with Steven J. Shoptaw, Ph.D., from the UCLA Department of Family Medicine, is spearheading a Phase I clinical safety trial that for the first time examines the effects of Ibudilast when administered with metamphetamine (MA), an addictive stimulant that is closely related to amphetamine.

26 Apr 2012

Scientists identify linchpin of fat metabolism

Humans are built to hunger for fat, packing it on during times of feast and burning it during periods of famine. But when deluged by foods rich in fat and sugar, the modern waistline often far exceeds the need to store energy for lean times, and the result has been an epidemic of diabetes, heart disease and other obesity-related problems.

26 Apr 2012

No link between lace-up ankle bracing and ACL injury

Giselle Aerni, MD presented her research project "The Effect of Lace-Up Ankle Bracing on Knee Biomechanics During a Jump Landing" at the 21st American Medical Society for Sports Medicine Annual Meeting in Atlanta, GA on April 24, 2012.

26 Apr 2012

Physical activity reduces oxidative stress in people with SCT

Sickle cell disease (SCD), an inherited condition that causes red blood cells to sometimes deform into a crescent shape, affects an estimated 100,000 Americans, typically those of African descent. However, far more have sickle cell trait (SCT), caused when individuals carry just a single copy of the disease-causing mutation in their genes.

26 Apr 2012

Commonwealth Fund Commission unveils community-based health plan

Noting the "unprecedented opportunity" provided under the Affordable Care Act, the Health Information Technology for Economic and Clinical Health (HITECH) Act, and other recently enacted federal laws, the Commonwealth Fund Commission on a High Performance Health System today unveiled a community-based plan to enhance health and reduce spending by improving care for chronically ill patients and targeting quality improvement efforts to conditions that can yield the greatest benefit in a relatively short time.

26 Apr 2012

ASIA honors SCI researchers with 2012 Apple Award

American Spinal Injury Association (ASIA) has awarded its 2012 Apple Award to the article by Mark Nash, PhD, et al, entitled, "Safety, tolerance, and efficacy of extended-release niacin monotherapy for treating dyslipidemia risks in persons with chronic tetraplegia: a randomized multicenter controlled trial."

26 Apr 2012

Intensive dialysis at home could increase survival chances for patients with ESRD

Patients suffering with end-stage renal disease could increase their survival chances by undergoing intensive dialysis at home rather than the conventional dialysis in clinics. A new study by Lawson Health Research Institute shows the potential of more intensive dialysis completed in a home setting.

26 Apr 2012

Gender differences in musculoskeletal health are not solely due to hormones

Osteoarthritis, osteoporosis, fractures, and spinal disorders are among the most common reasons for doctor visits. These conditions have more than one thing in common: they are all musculoskeletal problems and are more prevalent in women.

26 Apr 2012

Scientists gain new insight into signaling paths that control insulin production

Scientists from The Danish Stem Cell Center (DanStem) at the University of Copenhagen and Hagedorn Research Institute have gained new insight into the signaling paths that control the body's insulin production. This is important knowledge with respect to their final goal: the conversion of stem cells into insulin-producing beta cells that can be implanted into patients who need them.

26 Apr 2012

Pig mucus effective at blocking viruses associated with cervical and oral cancer

Scientists are reporting that the mucus lining the stomachs of pigs could be a long-sought, abundant source of "mucins" being considered for use as broad-spectrum anti-viral agents to supplement baby formula and for use in personal hygiene and other consumer products to protect against a range of viral infections. Their study appears in ACS' journal Biomacromolecules.

26 Apr 2012

NYU Langone expands MS Comprehensive Care Center

NYU Langone's Multiple Sclerosis (MS) Comprehensive Care Center recently opened the doors to a new clinical practice - the first to occupy NYU Langone Medical Center's new, nearly 300,000-square-foot Ambulatory Care Center located at 240 East 38th Street at Second Avenue in Manhattan.

26 Apr 2012

Study examines role of NLRP3 inflammasome in ventilator-induced lung injury

Mechanical ventilation is often lifesaving, but can also initiate or aggravate lung injury. A new study in the May issue of Anesthesiology examined the role of one particular receptor in the inflammatory pathway, the NLRP3 inflammasome, and whether it impacts ventilator-induced lung injury.

26 Apr 2012

UW researcher receives Dr. Harry L. Galanty Young Investigator Award

University of Washington researcher Jessie Fudge, MD received the Dr. Harry L. Galanty Young Investigator's Award for excellence in sports medicine research at the 21st American Medical Society for Sports Medicine Annual Meeting in Atlanta, Ga. on April 24, 2012.

26 Apr 2012

Latest AAN/AHS guidelines can help prevent migraine attacks

The latest American Academy of Neurology/American Headache Society Guidelines released this week outline evidence-based and effective treatments that can prevent migraine attacks and lessen their severity.

26 Apr 2012

FDA issues complete response letter to Takeda’s NDAs for type 2 diabetes investigational therapies

Takeda Pharmaceutical Company Limited and its wholly-owned subsidiary, Takeda Global Research & Development Center, Inc. today announced that the company received a complete response letter from the United States (U.S.) Food and Drug Administration (FDA) regarding New Drug Applications (NDAs) for alogliptin and fixed-dose combination (FDC) alogliptin and pioglitazone.

26 Apr 2012

Kv7.4 channels may play a fundamental role in high blood pressure

Scientists have identified what could be a biological tipping point in the development of high blood pressure, in a discovery that could one day lead to new treatment.

26 Apr 2012

EuroPRevent2012 to take place from May 3-5 in Dublin

EuroPRevent2012, the premier European event on cardiovascular disease (CVD) prevention, brings together the latest guidelines and studies focused on reducing the global epidemic of heart disease.

26 Apr 2012

Study uses brain data to predict how large populations will respond to ads

Advertisers and public health officials may be able to access hidden wisdom in the brain to more effectively sell their products and promote health and safety, UCLA neuroscientists report in the first study to use brain data to predict how large populations will respond to advertisements.

26 Apr 2012

Link between obesity and RA in women

Obesity and the painful autoimmune disorder rheumatoid arthritis are each becoming more common, raising a logical question: Could one have something to do with the other? For women, it appears there is a link, Mayo Clinic researchers say.

26 Apr 2012

Strong light can treat myocardial infarction

There are lots of ways to treat a heart attack - CPR, aspirin, clot-busters and more. Now CU medical school researchers have found a new candidate: Intense light.

26 Apr 2012