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Inspiration submits IB1001 BLA with FDA for treatment of hemophilia B

Ipsen today announced that its partner, Inspiration Biopharmaceuticals, Inc., has submitted a Biologics License Application (BLA) to the U.S. Food and Drug Administration (FDA) for the approval of IB1001, an intravenous recombinant factor IX (rFIX) for the treatment and prevention of bleeding in individuals with hemophilia B.

17 Apr 2012

UTHealth researcher studies novel cell therapy to prevent GVHD

A researcher at The University of Texas Health Science Center at Houston (UTHealth) is studying a novel cell therapy that could help avoid autoimmune problems after stem cell transplantation, as well as potentially treat other autoimmune diseases.

17 Apr 2012

AANS commemorates National Neurosurgery Awareness Week in Miami

The American Association of Neurological Surgeons (AANS) is commemorating National Neurosurgery Awareness Week (NNAW) April 15-21, 2012, in conjunction with its 80th Annual Scientific Meeting in Miami, held April 14-18, 2012.

17 Apr 2012

Vanda acquires license from Lilly to develop and commercialize NK-1R antagonist

Vanda Pharmaceuticals Inc., a biopharmaceutical company focused on the development and commercialization of products for central nervous system disorders, announced today that it has acquired an exclusive world-wide license from Eli Lilly and Company (Lilly) to develop and commercialize a small molecule neurokinin 1 receptor (NK-1R) antagonist for all human indications.

17 Apr 2012

Paper points out decision-making capacity of patients with dementia

Luis Carlos álvaro, a clinical neurologist at the Hospital of Basurto (Bilbao) and lecturer at the University of the Basque Country (UPV/EHU), has had an article published on the capacity of patients with dementia to make decisions. It is entitled Competencia: conceptos generales y aplicación en la demencia (Competence: general concepts and application in dementia), and has been published in the journal Neurología.

17 Apr 2012

Maternal depression may affect infants’ sleep

Sleep problems are common in young children and can lead to difficulties in families. Several factors likely contribute to these problems, and mothers' depression has consistently been identified as one. Now a new study has found that moms with higher levels of symptoms of depression might act in ways that disturb their infants' sleep.

17 Apr 2012

Study: Sharp increase in airborne pollens across Europe

When trees and plants release their pollen, millions of hay fever sufferers are affected by sneezing fits and itchy, watery eyes. Today in Germany, roughly every fourth person suffers from allergies - and this figure is set to rise. Climate change is seen as one of the factors fuelling the increase in allergic responses.

17 Apr 2012

More than one third of patients with invasive cancer are undertreated for their pain

More than one third of patients with invasive cancer are undertreated for their pain, with minorities twice as likely to not receive analgesics, according to research from The University of Texas MD Anderson Cancer Center.

17 Apr 2012

Simple two-question test more effective in identifying anxiety disorders in children

A University of British Columbia researcher has developed a simple two-question test to screen kindergarten-aged children for future anxiety disorders - the most commonly reported mental health concern among children.

17 Apr 2012

Depressed mothers more likely to wake up their infants at night

Depressed mothers are more likely to needlessly wake up their infants at night than mothers who are not depressed, according to Penn State researchers.

17 Apr 2012

Abnormal protein accumulation in the brain may lead to onset, severity of Parkinson's

Injection of a small amount of clumped protein triggers a cascade of events leading to a Parkinson's-like disease in mice, according to an article published online this week in the Journal of Experimental Medicine.

17 Apr 2012

Metformin associated with reduced risk of Parkinson's in patients with diabetes

A major 12-year study based on a Taiwanese population cohort has demonstrated that not only does diabetes increase the risk of developing Parkinson's disease more than 2-fold, the use of sulfonylureas, commonly used as treatment for diabetes, increases the risk further by about 57%. This study also found that by including metformin in the therapy, no increased risk in developing Parkinson's disease was recorded.

17 Apr 2012

ONO-4641 reduces number of lesions in people with MS

An investigational oral drug called ONO-4641 reduced the number of lesions in people with multiple sclerosis (MS), according to the results of a phase two clinical trial to be presented as Emerging Science at the American Academy of Neurology's 64th Annual Meeting in New Orleans April 21 to April 28, 2012.

17 Apr 2012

Steroids still work better for patients with sciatica

Despite the great promise that injecting a new type of anti-inflammatory pain medicine into the spine could relieve the severe leg and lower back pain of sciatica, a Johns Hopkins-led study has found that the current standard of care with steroid injections still does better.

17 Apr 2012

Study: 1 in 26 may develop epilepsy at some point in life

A landmark study from the Institute of Medicine (IOM) reports that your chance of developing epilepsy at some point in your life is one in 26. Onset is highest in children and older adults. But epilepsy knows no boundaries—it can strike at any age and across all socio-economic levels and ethnicities. There is no known cure and one-third of people with epilepsy have treatment-resistant or refractory epilepsy.

17 Apr 2012

Football-related brain injuries appear to rise among high school students

Catastrophic brain injuries associated with full-contact football appear to be rising, especially among high school students, according to a new report.

17 Apr 2012

High-fibre diet protects women from cardiovascular disease

Foods high in fibre provide good protection against cardiovascular disease, and the effect is particularly marked in women. This is shown in a new study from Lund University in Sweden.

17 Apr 2012

Morphotek commences MORAb-004 Phase II study in metastatic colorectal cancer

Morphotek, Inc., a subsidiary of Eisai Inc., announced today that it has commenced a multi-center, Phase II study evaluating the safety and efficacy of MORAb-004 in the treatment of metastatic colorectal cancer that is refractory to all standard therapy.

17 Apr 2012

Study pinpoints compounds that repress cancer gene’s activity

A research team pursuing one of the most commonly altered genes in cancer has laid a critical foundation for understanding this gene that could point the way toward developing drugs against it. A recent study of cancer genetics pointed to the gene MCL1, which encodes a protein that helps keep cells alive

17 Apr 2012

Cosmetics may contain chemicals that raise risk of obesity and diabetes

Scientists found that those who were exposed to phthalates, colourless man-made substances included in a variety of common consumer products, were more prone to weight gain. And subjects with even 'modest' levels of the substance in their bloodstream were twice as likely to develop diabetes.

16 Apr 2012