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Metastatic renal cell carcinoma (mRCC) therapy: an interview with Charles A. Nicolette, Ph.D., CSO of Argos Therapeutics

Metastatic renal cell carcinoma is a devastating disease. There are roughly 20-25,000 new cases per year in the United States and it is increasing for some reason.

12 Feb 2013

Problem drinkers’ depression often related to heavy alcohol intake

For problem drinkers, bouts of depressive symptoms are often the direct result of their heavy alcohol intake, according to a study in the March issue of the Journal of Studies on Alcohol and Drugs.

12 Feb 2013

Berkeley Lab researchers resolve EGFR activation mystery

Researchers with Lawrence Berkeley National Laboratory (Berkeley Lab) and the University of California (UC) Berkeley have provided important new details into the activation of the epidermal growth factor receptor (EGFR), a cell surface protein that has been strongly linked to a large number of cancers and is a major target of cancer therapies.

12 Feb 2013

Young adults with depression symptoms may benefit from computerized avatars

Young adults, in a period of transition, are often reluctant to seek treatment for mental health problems because of the stigma, inadequate insurance coverage and difficulty finding a mental health care provider.

12 Feb 2013

Study finds reduced insulin effectiveness, high blood pressure in first-born children

Long a source of sibling rivalry, birth order may raise the risk of first-born children developing diabetes or high blood pressure, according to a recent study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM).

12 Feb 2013

Strokes that occur during or shortly after surgery can be devastating

Strokes that occur during or shortly after surgery can be devastating, resulting in longer hospital stays and increased risks of death or long-term disability.

12 Feb 2013

Blood vessels play an important role in preventing spread of tumour cells

A lack of the protein endoglin in the blood vessels of tumour-bearing mice enables the spread of daughter tumours, according to researchers at Karolinska Institutet and Lund University in Sweden in a study published in the scientific periodical The Journal of Experimental Medicine. Given that the tumour vasculature constitutes an important barrier to the spread of cancer cells, the team suggests that drugs should be developed to strengthen the blood vessels' protective function.

12 Feb 2013

Developing tiny probes for research and brain-related medical applications

Developing tiny probes for research and brain-related medical applications - that is the goal of the project NeuroSeeker, launched in February 2013 with a kick-off event in Leuven, Belgium.

12 Feb 2013

Florida Hospital, Sanford-Burnham and Takeda renew research agreement

Sanford-Burnham Medical Research Institute (Sanford-Burnham) and Florida Hospital announced today that they have renewed a research agreement with Takeda Pharmaceutical Company Limited (Takeda) to extend their collaboration to discover and evaluate new therapeutic approaches to obesity. The collaboration uses a research and drug-development model that creates an early feedback loop in the discovery pipeline.

12 Feb 2013

New cancer research to be highlighted in AACR Annual Meeting 2013

The AACR Annual Meeting 2013 will bring more than 17,000 scientists, advocates, industry leaders and other professionals to Washington, D.C., for the latest in breakthrough cancer science.

12 Feb 2013

Community health workers can help individuals better manage their diabetes

Newly published results from a randomized controlled clinical trial in the Pacific U.S. territory of American Samoa add clear evidence for the emerging idea that community health workers can meaningfully improve type 2 diabetes care in medically underserved communities.

12 Feb 2013

RNF20 protein required for MLL-rearranged leukemia amplification

Acute myeloid leukemia (AML) is an aggressive blood cancer that is currently incurable in 70% of patients. In a bold effort, CSHL scientists are among those identifying and characterizing the molecular mechanisms responsible for this cancer in order to generate potential new therapeutics.

12 Feb 2013

Southampton scientists create new method to generate bone cells

Scientists at the University of Southampton have created a new method to generate bone cells which could lead to revolutionary bone repair therapies for people with bone fractures or those who need hip replacement surgery due to osteoporosis and osteoarthritis.

12 Feb 2013

Tips on avoiding a Valentine's Day Headache

February 14 is right around the corner, and no one wants to spend Valentine's day, or the day after, with a severe headache and some of its accompaniments – nausea, vomiting, sensitivity to light and sound. And you certainly don't want your gift to be the culprit in producing a headache.

12 Feb 2013

Valor, Oxygen Biotherapeutics enter License and Supply Agreement for Dermacyte

Oxygen Biotherapeutics, Inc., announced today that it has entered into a License and Supply Agreement with the Cosmetics Division of Valor SA of Lausanne, Switzerland, for Dermacyte, a perfluorocarbon based cosmetic product currently manufactured and distributed by Oxygen Biotherapeutics.

11 Feb 2013

Researchers identify miR-506 as potential therapeutic candidate for metastatic ovarian cancer

Researchers employed an extensive analysis of genomic information to identify a new, high-risk cohort of ovarian cancer patients, characterize their tumors, find a potential treatment and test it in mouse models of the disease.

11 Feb 2013

Valproate, pregnancy and IQ: an interview with Professor Kimford Meador

Valproate (sodium salt of valproic acid) is an anticonvulsant used in the treatment of epilepsy, migraine and bipolar disorder as well as some other off label psychiatric indications.

11 Feb 2013

Researchers discover miR-27b that regulates lipid levels in the blood

Researchers have identified a microRNA liver gene, miR-27b, which regulates lipid (cholesterol or fat) levels in the blood. This regulator gene controls multiple genes involved in dyslipidemia-abnormal blood cholesterol levels that can contribute to heart disease.

11 Feb 2013

Combined genomic and proteomic plasma analysis can identify molecular disease mechanisms

For the first time, scientists have combined genomic and proteomic analysis of blood plasma to enhance identification of genetically regulated protein traits. This could be applied to any large association study of civilization diseases where blood plasma has been collected, vastly improving a clinician's ability to identify disease susceptibility in individuals and populations.

11 Feb 2013

Symposium to discuss new techniques for assessing risk of acute kidney injury

Leading critical care experts will discuss new techniques for assessing risk of acute kidney injury (AKI) at an educational symposium to be held at the Eighteenth International Conference on Continuous Renal Replacement Therapies (CRRT) in San Diego.

11 Feb 2013