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FUS RNA binding ability essential for development of Amyotrophic Lateral Sclerosis

Research led by Dr. Udai Pandey, Assistant Professor of Genetics at LSU Health Sciences Center New Orleans, has found that the ability of a protein made by a gene called FUS to bind to RNA is essential to the development of Amyotrophic Lateral Sclerosis (ALS). This discovery identifies a possible therapeutic target for the fatal neurological disease.

20 Dec 2012

Misdiagnosis of obsessive compulsive disorder and ADHD can jeopardize patient care

On the surface, obsessive compulsive disorder (OCD) and attention deficit/hyperactivity disorder (ADHD) appear very similar, with impaired attention, memory, or behavioral control. But Prof. Reuven Dar of Tel Aviv University's School of Psychological Sciences argues that these two neuropsychological disorders have very different roots - and there are enormous consequences if they are mistaken for each other.

20 Dec 2012

Men with fibromyalgia symptoms less likely to receive diagnostic tests

Fibromyalgia is a complex illness to diagnose and to treat. There is not yet a diagnostic test to establish that someone has it, there is no cure and many fibromyalgia symptoms -- pain, fatigue, problems sleeping and memory and mood issues -- can overlap with or get mistaken for other conditions. A new Mayo Clinic study suggests that many people who have fibromyalgia, especially men, are going undiagnosed.

20 Dec 2012

Newtown shooting spotlights gaps in mental health care

The elementary school massacre prompts an examination of mental health care policies and access to guns by the mentally ill.

20 Dec 2012

Study focuses on hormone-sensitive breast tumours

Gene expression in breast cancer provides valuable biological information for better determining the diagnosis, treatment, risk of relapse and survival rate. However, the most common form of characterizing breast cancer is by histopathological techniques. This study, headed by Dr Aleix Prat, Head of the Translational Genomics Group at the Vall d'Hebron Institute of Oncology (VHIO) and an oncologist at the Breast Cancer Unit of the Vall d´Hebron University Hospital, focused on hormone-sensitive breast tumours known as luminals.

20 Dec 2012

Study finds no clear indication 9/11 debris causes cancer

The study, published in the Journal of the American Medical Association, examined the health of nearly 56,000 people.

20 Dec 2012

Amgen to pay $762 million fine for improper drug marketing

Biotech giant Amgen Inc. pleaded guilty in federal court to improper marketing of its anemia drug Aranesp and has agreed to pay $762 million in criminal fines and civil settlements to resolve complaints from company whistle-blowers. Federal prosecutors in New York said the Thousand Oaks company was "pursuing profits at the risk of patient safety" by encouraging doctors to use its popular anemia drug for unapproved uses to boost sales and to take market share from a rival drug maker.

20 Dec 2012

Scientists uncover TDP-43 protein as possible target for treatment of ALS, FTD

Neuroscientists at Georgetown University Medical Center say they have new evidence that challenges scientific dogma involving two fatal neurodegenerative diseases - amyotrophic lateral sclerosis (ALS), and frontotemporal dementia (FTD) - and, in the process, have uncovered a possible therapeutic target as a novel strategy to treat both disorders.

20 Dec 2012

Patients with hypertension or diabetes have increased risk of cancer recurrence, survival

By all accounts, a combination of colon cancer, diabetes and high blood pressure can be a recipe for medical disaster. Now, a new study led by a surgical oncologist and researcher at Temple University School of Medicine and Fox Chase Cancer Center has shown just how deadly this mix can be.

20 Dec 2012

New clues in understanding how epithelial cells repair themselves following chlorine-related injury

Scarring of the airways can lead to long-term breathing problems for some people exposed to high levels of chlorine gas from events such as an industrial accident, chemical spill following a train derailment or terroristic chemical warfare. Household mishaps from mixing bleach with acidic cleaning products also can cause release of chlorine gas; if this occurs in a poorly ventilated space, chlorine levels could be high enough to cause lung injury.

20 Dec 2012

GI bacteria exert some control over their hosts' appetites: Review

Over the last half decade, it has become increasingly clear that the normal gastrointestinal (GI) bacteria play a variety of very important roles in the biology of human and animals. Now Vic Norris of the University of Rouen, France, and coauthors propose yet another role for GI bacteria: that they exert some control over their hosts' appetites.

20 Dec 2012

Investigators report non-coding miRNAs as appealing biomarkers for cancer malignancy

As many as 50 percent of all human protein-coding genes are regulated by microRNA (miRNA) molecules. While some miRNAs impact onset and progression of cancer, others can actually suppress the development of malignant tumors and are useful in cancer therapy. They can also serve as potential biomarkers for early cancer detection. In a new issue of Cancer Biomarkers, investigators report on non-coding miRNAs as appealing biomarkers for malignancy.

20 Dec 2012

Hospitals with good work environment have low readmission rates

New research from the University of Pennsylvania School of Nursing has found that Medicare patients treated in hospitals with a good work environment for nurses had up to ten percent lower odds of readmission than those treated in hospitals with a poor work environment.

20 Dec 2012

Positive top-line results from Idera’s IMO-3100 Phase 2a trial on plaque psoriasis

Idera Pharmaceuticals today announced that 48% of patients with moderate-to-severe plaque psoriasis (12 of 25) treated with IMO-3100, a selective antagonist of Toll-like Receptors (TLRs) 7 and 9, demonstrated improvements in Psoriasis Area Severity Index (PASI) scores of 35% to 90% from baseline at the completion of a randomized, double-blind, placebo-controlled Phase 2a clinical trial of two dose levels of IMO-3100 administered for four weeks, with a four-week follow-up period.

20 Dec 2012

New therapeutic ultrasound approach could lead to an invisible knife for noninvasive surgery

A carbon-nanotube-coated lens that converts light to sound can focus high-pressure sound waves to finer points than ever before. The University of Michigan engineering researchers who developed the new therapeutic ultrasound approach say it could lead to an invisible knife for noninvasive surgery.

20 Dec 2012

Link made between muscular dystrophy and defective nerve wiring

Working with mice, Johns Hopkins scientists have discovered that a particular protein helps nerve cells extend themselves along the spinal cord during mammalian development. Their results shed light on the subset of muscular dystrophies that result from mutations in the gene that holds the code for the protein, called dystroglycan, and also show how the nerve and muscle failings of the degenerative diseases are related.

20 Dec 2012

Household rules can help parents resolve conflicts and guard children's mental health

Holiday presents will soon be under the tree for millions of adolescents. With those gifts may come sibling squabbles over violations of personal space, such as unwanted borrowing of a fashionable clothing item, or arguments over fairness, such as whose turn it is to play a new video game. Those squabbles represent two specific types of sibling conflict that can have different effects on a youth's emotional health, according to a multi-year study by a University of Missouri psychologist.

20 Dec 2012

Study helps reveal how nervous system modulates motor control patterns

Most people are impressed by how a toad jumps. UC Irvine biologist Emanuel Azizi is more impressed by how one lands. An assistant professor of ecology & evolutionary biology who specializes in muscle physiology and biomechanics, Azizi found that nature's favorite leapers possess a neuromuscular response that's specific to the intensity of a landing - a mechanism that protects muscles from injury upon impact.

20 Dec 2012

Researchers reveal role of dendritic cells in Type 1 diabetes

The researchers reveal the role of the innate immune cells, especially the dendritic cells, that cause the activation of the killer T-lymphocytes whose action is directed against the p pancreatic cells. The results obtained in mice make it possible to consider new ways of regulating the auto-immune reaction generated by the innate immune cells.

20 Dec 2012

Seattle Times examines partnership between Hutchinson Cancer Research Center, Uganda Cancer Institute

The Seattle Times examines a partnership between the Fred Hutchinson Cancer Research Center and the Uganda Cancer Institute (UCI). In 2008, "the two institutes formally agreed to collaborate on clinical care and research projects, and more recently a major building project at Uganda's only cancer-research center," the newspaper writes.

20 Dec 2012

Medical Condition News

FUS RNA binding ability essential for development of Amyotrophic Lateral Sclerosis

Misdiagnosis of obsessive compulsive disorder and ADHD can jeopardize patient care

Men with fibromyalgia symptoms less likely to receive diagnostic tests

Newtown shooting spotlights gaps in mental health care

Study focuses on hormone-sensitive breast tumours

Study finds no clear indication 9/11 debris causes cancer

Amgen to pay $762 million fine for improper drug marketing

Scientists uncover TDP-43 protein as possible target for treatment of ALS, FTD

Patients with hypertension or diabetes have increased risk of cancer recurrence, survival

New clues in understanding how epithelial cells repair themselves following chlorine-related injury

GI bacteria exert some control over their hosts' appetites: Review

Investigators report non-coding miRNAs as appealing biomarkers for cancer malignancy

Hospitals with good work environment have low readmission rates

Positive top-line results from Idera’s IMO-3100 Phase 2a trial on plaque psoriasis

New therapeutic ultrasound approach could lead to an invisible knife for noninvasive surgery

Link made between muscular dystrophy and defective nerve wiring

Household rules can help parents resolve conflicts and guard children's mental health

Study helps reveal how nervous system modulates motor control patterns

Researchers reveal role of dendritic cells in Type 1 diabetes

Seattle Times examines partnership between Hutchinson Cancer Research Center, Uganda Cancer Institute

Digital pathology and the PathoVerse: A conversation with Dr. Singh

Bioprocess Efficiency with Cell Density Monitoring

Exploring electron microscopy for plant and microbial imaging at the John Innes Centre

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