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African-Americans have higher burden of multiple, large-joint OA

New research suggests African Americans have a higher burden of multiple, large-joint osteoarthritis (OA), and may not be recognized based on the current definition of "generalized OA."

21 Oct 2011

UH scientists recommend new drug strategies for chronic diseases

Researchers at the University of Houston (UH) are recommending a new strategy for developing drugs to treat cancer, multiple sclerosis, Alzheimer's and cardiovascular diseases.

21 Oct 2011

Mortality rate from homicide, suicide more common in pregnant and postpartum women

Violent deaths are outpacing traditional causes of maternal mortality, such as hemorrhage and preeclampsia, and conflicts with intimate partner are often a factor, researchers report.

21 Oct 2011

New metabolic pathway for controlling brain inflammation

A team led by scientists from The Scripps Research Institute has identified a new metabolic pathway for controlling brain inflammation, suggesting strategies for treating it.

21 Oct 2011

UTS, Agilent establish joint nuclear magnetic resonance research facility

Agilent Technologies Inc. and the University of Technology, Sydney, today announced the establishment of a joint nuclear magnetic resonance research facility.

21 Oct 2011

Dual role for VEGF in regulating skin cancer stem cells and tumor progression

In a study published in Nature, researchers lead by Cédric Blanpain, MD/PhD, FNRS/FRS researcher and WELBIO investigator at the IRIBHM, Université libre de Bruxelles, Belgium, in collaboration with the groups of Peter Carmeliet (VIB/K.U.Leuven) and Jody J. Haigh (VIB/UGent) identify a new role for Vascular Endothelial Growth Factor (VEGF) in regulating skin cancer stem cells.

21 Oct 2011

Study links leptin levels with symptoms of depression, anxiety

A new study has for the first time in humans linked levels of leptin, a hormone produced by fat cells, with symptoms of depression and anxiety independent of weight.

21 Oct 2011

OncoGenex commences enrollment in OGX-427 Phase II trial for bladder cancer

OncoGenex Pharmaceuticals, Inc. announced today that it has initiated patient enrollment in a randomized, Phase II clinical trial evaluating OGX-427, an inhibitor of heat shock protein 27 (Hsp27), in patients with advanced bladder cancer.

21 Oct 2011

Byetta combination with insulin glargine gets FDA nod in type 2 diabetes

The US Food and Drugs Administration (FDA) has approved Byetta (exenatide) injection as add-on treatment for use with insulin glargine, together with exercise and diet for diabetes type 2 patients who are not responding well enough to glargine alone. Byetta's add-on therapy is for those on glargine with metformin and/or a TZD (thiazolidinedione) or without.

20 Oct 2011

An encouraging decline in heart failure admission numbers: Study

According to heartening news from researchers, hospitalizations for heart failure have dropped 29.5 percent nationally over the past decade. Researchers explain that this is largely because fewer patients were admitted rather than fewer admissions per patient, researchers found.

20 Oct 2011

OncoSec submits Device Master File for OMS to FDA

OncoSec Medical Incorporated, which is developing its advanced-stage OMS ElectroOncology therapies for the treatment of solid tumor cancers, announced today the submission of its Device Master File (DMF) to the U.S. Food and Drug Administration (FDA) for its patented OncoSec Medical System (OMS) which consists of a generator and hand-held applicator.

20 Oct 2011

Neuroscientists discover normal brain communication in people with AgCC

Like a bridge that spans a river to connect two major metropolises, the corpus callosum is the main conduit for information flowing between the left and right hemispheres of our brains. Now, neuroscientists at the California Institute of Technology have found that people who are born without that link-a condition called agenesis of the corpus callosum, or AgCC-still show remarkably normal communication across the gap between the two halves of their brains.

20 Oct 2011

TGen collaborates with Samuel Oschin Comprehensive Cancer Institute for clinical trials

Cedars-Sinai has combined efforts with the Translational Genomics Research Institute (TGen) in Arizona so researchers may offer joint clinical trials and collaborate to develop personalized therapies that could lead to more effective cancer treatments.

20 Oct 2011

New surgical tool can identify tumor margins during brain operation

Scientists are reporting development and successful initial testing of a new tool that tells whether brain tissue is normal or cancerous while an operation is underway, so that surgeons can remove more of the tumor without removing healthy tissue, improving patients' survival.

20 Oct 2011

University of Delaware receives DoD grant to create and manage BADER Consortium

The Department of Defense (DoD) Congressionally Directed Medical Research Programs (CDMRP) Peer Reviewed Orthopaedic Research Program (PRORP) has awarded a $19.7 million grant to the University of Delaware to create and manage a consortium that will improve the quality of life for warfighters who suffer significant limb injuries in combat.

20 Oct 2011

Intestinal ecosystem more dynamic than previously thought

The intestinal ecosystem is even more dynamic than previously thought, according to two studies by UT Southwestern Medical Center researchers published in the latest issue of Science.

20 Oct 2011

New prosthetic design may not offer same benefits for all knee replacement recipients

Undergoing a knee replacement involves sophisticated medical equipment, but innovative prosthetic design may not offer the same benefits for all knee replacement recipients, Yale School of Medicine researchers report in a perspective article in the October 20 issue of New England Journal of Medicine.

20 Oct 2011

OPHN1 protein mediates mGluR-dependent longterm depression at synapses

Scientists at Cold Spring Harbor Laboratory (CSHL) have solved part of a puzzle concerning the relationship between changes in the strength of synapses - the tiny gaps across which nerve cells in the brain communicate - and dysfunctions in neural circuits that have been linked with drug addiction, mental retardation and other cognitive disorders.

20 Oct 2011

JAMA study: Heart failure hospitalization rates fall

The rate of hospital admissions for elderly patients in the U.S. fell by nearly 30 percent in the past decade, based on an analysis of Medicare data. This finding, being published today, is viewed as progress against cardiovascular disease and the costs associated with this illness.

20 Oct 2011

Rituximab may alleviate chronic fatigue syndrome through B-lymphocyte depletion

Chronic fatigue syndrome (CFS) may be alleviated by the anti-cancer drug Rituximab, suggesting that the source of the disease could lie in the immune system, according to a new study published Oct. 19 in the online journal PLoS ONE.

20 Oct 2011