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Researchers identify mechanism of platelet hyperactivation in COVID-19 patients

A recent study conducted at the University of Pennsylvania and the Children’s Hospital of Philadelphia, USA, has revealed the mechanism of platelet hyperactivation in critically ill coronavirus disease 2019 (COVID-19) patients.

4 May 2021

What happens in the first few days of SARS-CoV-2 infection?

New research, published in PLOS Biology, has evaluated SARS-CoV-2 infection in primary cultures of well-differentiated cells to determine how the virus affects the body and how the infection starts. Answers to these questions are essential to forming a general understanding of viral pathogenesis, which helps us develop effective prevention and treatment strategies for COVID-19.

4 May 2021

Can SARS-CoV-2’s impairment of endothelium cause vascular disease?

The study, published in the journal Circulation Research, suggests that COVID-19 is not only a respiratory disease but also a vascular disease. It highlights how the virus attacks the vascular system, causing endothelial impairment.

4 May 2021

Moderna COVID-19 vaccine makes it on WHO Emergency Use Listing

Moderna has announced Emergency Use Listing granted by the World Health Organization for its COVID-19 mRNA vaccine.

4 May 2021

COVID-19 in pregnancy does not significantly increase respiratory illness in newborns, says study

A new study published in the journal JAMA offers reassuring evidence that infants born to mothers with coronavirus disease 2019 (COVID-19), or even asymptomatic infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have little increase in respiratory symptoms over babies born to uninfected mothers.

4 May 2021

Critical care nurses in poor physical and mental health report more medical errors

A study led by The Ohio State University College of Nursing finds that critical care nurses in poor physical and mental health reported significantly more medical errors than nurses in better health.

4 May 2021

Could in vitro glycoengineering help produce better SARS-CoV-2 spike candidates for vaccine research?

A vexing problem in the development of vaccines has been the need to achieve the right glycosylation profile for the viral antigens. A new study, recently released as a preprint on the bioRxiv* server, shows how a sequential cell-free approach produced complex N-glycans from simpler types, in a one-pot reaction.

4 May 2021

Early exposure to air pollutants linked to high blood pressure in children, adolescents

A meta-analysis of 14 air pollution studies from around the world found that exposure to high levels of air pollutants during childhood increases the likelihood of high blood pressure in children and adolescents, and their risk for high blood pressure as adults.

4 May 2021

Four-part small-molecule cocktail can prevent cellular stress

Researchers at the National Institutes of Health (NIH) have devised a four-part small-molecule cocktail that can protect stem cells called induced pluripotent stem cells (iPSCs) from stress and maintain normal stem cell structure and function.

4 May 2021

Developmental abnormalities are controlled by genetics of the fetus and placenta

Yale researchers have shown that developmental abnormalities, including those that lead to pregnancy loss and autism, are controlled by the genetics of the fetus and placenta -- and not the mother's intrauterine environment.

4 May 2021

Ravi Sheth receives 2020 Hertz thesis prize for transforming microbial research

Hertz Fellow Ravi Sheth says his lab in the Brooklyn Navy Yard is "like a Willy Wonka factory of microbes" geared toward improving the taste and safety of food and beverages.

4 May 2021

Rapid and sensitive SARS-CoV-2 detection from saliva using CRISPR

In a paper recently uploaded to the preprint server medRxiv by Edward Málaga Trillo et al. (April 29th, 2021), these methods are tested in combination with CRISPR-Cas detection in the field, demonstrating a sensitivity and specificity of 93.8% and 99%, respectively.

4 May 2021

New computational tool helps screen molecules for their potential COVID-fighting properties

A year into the COVID-19 pandemic, mass vaccinations have begun to raise the tantalizing prospect of herd immunity that eventually curtails or halts the spread of SARS-CoV-2.

4 May 2021

Uncertainty during first COVID-19 lockdown had negative impact on mental health

Many people in Switzerland experienced considerable psychological distress during the first COVID-19 lockdown from mid-March to the end of April 2020.

4 May 2021

Researchers discover new way to improve the subcutaneous administration of mRNA

If not before, then certainly since the first messenger RNA (mRNA) vaccines to combat the SARS CoV2 virus were approved in Germany, mRNA has become a recognized term even outside scientific circles.

4 May 2021

Study reveals major factors that affect bone health in hematopoietic stem cell transplantation recipients

Impaired bone health is among the most significant long-term consequences of hematopoietic stem cell transplantation (HSCT), a common therapy for patients with malignant and non-malignant hematological diseases.

4 May 2021

Evidence that elevated blood glucose is a significant risk factor for severe COVID-19

The literature analysis pointed to elevated blood glucose levels as a leading facilitator in the progression of COVID-19. Evidence linking elevated glucose to various steps in the life cycle of the virus and presentation of COVID-19 symptoms were also found.

3 May 2021

SARS-CoV-2 study in human gut organoids

Most of the major life-threatening symptoms of COVID-19 disease are associated with the host's generation of an exacerbated pro-inflammatory immune response. Many studies have correlated the intensity of the immune response with the severity of disease.

3 May 2021

Study shows a protective association between anticoagulants and COVID-19

In a new study, researchers investigated the association between the use of oral anticoagulants and warfarin in COVID-19 disease outcomes. They published their results in a paper on the medRxiv* preprint server.

3 May 2021

Differential NK cell activity found to contribute to SARS-CoV-2 infection resistance

The COVID-19 pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected millions of people worldwide and is the leading cause of mortality in Brazil in 2020 as well as early 2021. Clinical manifestations of COVID-19 disease range from no symptoms and mild flu-like symptoms to severe cases leading to hospitalization and death.

3 May 2021

Medical Research News

Researchers identify mechanism of platelet hyperactivation in COVID-19 patients

What happens in the first few days of SARS-CoV-2 infection?

Can SARS-CoV-2’s impairment of endothelium cause vascular disease?

Moderna COVID-19 vaccine makes it on WHO Emergency Use Listing

COVID-19 in pregnancy does not significantly increase respiratory illness in newborns, says study

Critical care nurses in poor physical and mental health report more medical errors

Could in vitro glycoengineering help produce better SARS-CoV-2 spike candidates for vaccine research?

Early exposure to air pollutants linked to high blood pressure in children, adolescents

Four-part small-molecule cocktail can prevent cellular stress

Developmental abnormalities are controlled by genetics of the fetus and placenta

Ravi Sheth receives 2020 Hertz thesis prize for transforming microbial research

Rapid and sensitive SARS-CoV-2 detection from saliva using CRISPR

New computational tool helps screen molecules for their potential COVID-fighting properties

Uncertainty during first COVID-19 lockdown had negative impact on mental health

Researchers discover new way to improve the subcutaneous administration of mRNA

Study reveals major factors that affect bone health in hematopoietic stem cell transplantation recipients

Evidence that elevated blood glucose is a significant risk factor for severe COVID-19

SARS-CoV-2 study in human gut organoids

Study shows a protective association between anticoagulants and COVID-19

Differential NK cell activity found to contribute to SARS-CoV-2 infection resistance

Advancing Menopause Care: Non-Hormonal Treatments for Vasomotor Symptoms

Building quality into drug development for safer, faster medicines

How Pulp Fixin Is Turning Paper into High-Performance Sustainable Labware

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