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Novel hydrogel-based vaccine formulation shows high efficacy against SARS-CoV-2

A fascinating new preprint research paper posted to the bioRxiv* server discusses impressively high neutralizing responses elicited with a single dose of a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine formulation, which could help turn the tide of the current pandemic if validated.

6 Apr 2021

Researchers define genetic landscape of uterine leiomyosarcomas

In a new study, Yale Cancer Center researchers have defined the genetic landscape of uterine leiomyosarcomas (uLMS).

6 Apr 2021

Research explores sex differences in placental defenses against SARS-CoV-2 infection

A plethora of earlier studies has reported on the differences between the sexes in susceptibility to the currently circulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), as well as its severity. A new preprint research paper posted to the bioRxiv* server extends this to the placenta in pregnancy.

6 Apr 2021

Oncogenic RAS mutations are responsible for regrowth of cancer cells following genotoxic therapies

In the fight against cancers, activating mutations in the RAS family of genes stand in the way of finding viable treatment options.

6 Apr 2021

South Africa SARS-CoV-2 variant B.1.351 easily escapes Sputnik vaccine

A new preprint research paper posted to the medRxiv* server reports on vaccine resistance data that pushes the end of the pandemic further away.

6 Apr 2021

New nanoparticle SARS-CoV-2 vaccine confers robust protection with single dose after two weeks

In a methodologically ‘state-of-the-art’ approach, US researchers have developed a protein-based nanoparticle vaccine against coronavirus disease (COVID-19), with a swift generation of antibodies and the potential to protect individuals who cannot receive other COVID-19 vaccines for medical reasons. The research is posted to the bioRxiv* preprint server.

5 Apr 2021

Devastating liver disease itching turns out to have a surprising cause

A devastating itching of the skin driven by severe liver disease turns out to have a surprising cause. Its discovery points toward possible new therapies for itching, and shows that the outer layer of the skin is so much more than insulation.

5 Apr 2021

Study: Alzheimer's disease treatments could reduce the financial burden to U.S. state budgets

Alzheimer's disease treatments that slow progression of the disease could significantly reduce the financial burden to U.S. state budgets, according to a new USC study.

5 Apr 2021

Masks, good ventilation are more important than social distancing for reducing COVID spread

A new study from the University of Central Florida suggests that masks and a good ventilation system are more important than social distancing for reducing the airborne spread of COVID-19 in classrooms.

5 Apr 2021

Temple, Case Western scientists receive $3 million NIH grant to study pathway behind heart failure

Like a bad water pump that fails to circulate coolant in a car engine, a failing heart struggles to pump blood through the body, causing symptoms of fatigue, shortness of breath, and swelling in the legs and feet.

5 Apr 2021

Cavity shave margin resection reduces the rate of positive margins in patients with DCIS

According to the American Cancer Society, a noninvasive breast cancer called ductal carcinoma in situ (DCIS) accounts for approximately one of every four new breast cancer cases in the United States.

5 Apr 2021

EMS workers face triple the risk for mental health problems

Emergency medical service (EMS) workers face triple the risk for significant mental health problems such as depression and posttraumatic stress disorder compared to the general population, according to a recently published study by researchers from Syracuse University.

5 Apr 2021

Researchers study how social media misinformation influences vaccine readiness in Appalachia

The saying goes, "You can't believe everything you find on the Internet." As simple as that sounds, navigating social media can often blur the line between reality and fantasy. This proves especially difficult when trying to fight a global pandemic.

5 Apr 2021

Survey: Public trust in the CDC has declined during COVID-19 pandemic

Public trust in the federal Centers for Disease Control and Prevention has fallen during the coronavirus pandemic, with the decline bringing overall population-level trust in the agency to the same lower level of trust long held by Black Americans about the agency, according to a new RAND Corporation study.

5 Apr 2021

Anxiety among men transitioning into parenthood is higher than reported

The transition to parenthood is a major life event that's often accompanied with new challenges related to financial, relationship, and work-life balance concerns.

5 Apr 2021

Different neural circuitries linked to distinct Parkinsonian behavioral deficits

Parkinson's disease (PD) is well known as a debilitating disease that gradually worsens over time. Although the disease's progression has been largely tied to the loss of motor functions, non-motor symptoms, including the loss of cognitive abilities, often emerge early in the disease.

5 Apr 2021

Can universal vaccines and treatments against future SARS-CoV-2 variants be developed?

A team of researchers from Saudi Arabia and Spain recently quantified the rapid evolution of SARS-CoV-2 by tracking the mutations of the virus globally, focusing on the receptor-binding domain (RBD) of the virus’s spike protein, which determines its infectivity.

5 Apr 2021

Researchers Identify potent small molecule inhibitors against SARS-CoV-2

A team of scientists from the USA and Sweden has recently screened 8 million small molecule inhibitors against SARS-CoV-2.

5 Apr 2021

SARS-CoV-2 cryptic transmission modeling shows emergence of first wave in US and Europe

To analyze this cryptic transmission phase and the first wave of the pandemic that ensued, researchers from Italy, UK, and the US used a data-driven, spatial, stochastic, and age-structured epidemic model. They developed a mechanistic understanding of the evolution of the epidemic and estimated the time required for local transmission in various states and countries. The model developed by the team offers a statistical idea of SARS-CoV-2 introductions across European countries and many states in the US.

5 Apr 2021

The use of mammalian cell surface display for rapid characterization of SARS-CoV-2 variants

A research group from the U.S. demonstrated the practicality of a spike display system in order to accelerate vaccine design, but also to swiftly appraise the effects of mutations in emerging strains of the SARS-CoV-2.

5 Apr 2021

Medical Research News

Novel hydrogel-based vaccine formulation shows high efficacy against SARS-CoV-2

Researchers define genetic landscape of uterine leiomyosarcomas

Research explores sex differences in placental defenses against SARS-CoV-2 infection

Oncogenic RAS mutations are responsible for regrowth of cancer cells following genotoxic therapies

South Africa SARS-CoV-2 variant B.1.351 easily escapes Sputnik vaccine

New nanoparticle SARS-CoV-2 vaccine confers robust protection with single dose after two weeks

Devastating liver disease itching turns out to have a surprising cause

Study: Alzheimer's disease treatments could reduce the financial burden to U.S. state budgets

Masks, good ventilation are more important than social distancing for reducing COVID spread

Temple, Case Western scientists receive $3 million NIH grant to study pathway behind heart failure

Cavity shave margin resection reduces the rate of positive margins in patients with DCIS

EMS workers face triple the risk for mental health problems

Researchers study how social media misinformation influences vaccine readiness in Appalachia

Survey: Public trust in the CDC has declined during COVID-19 pandemic

Anxiety among men transitioning into parenthood is higher than reported

Different neural circuitries linked to distinct Parkinsonian behavioral deficits

Can universal vaccines and treatments against future SARS-CoV-2 variants be developed?

Researchers Identify potent small molecule inhibitors against SARS-CoV-2

SARS-CoV-2 cryptic transmission modeling shows emergence of first wave in US and Europe

The use of mammalian cell surface display for rapid characterization of SARS-CoV-2 variants

Advancing Menopause Care: Non-Hormonal Treatments for Vasomotor Symptoms

Building quality into drug development for safer, faster medicines

How Pulp Fixin Is Turning Paper into High-Performance Sustainable Labware

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