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Study: Abundance of iron can drive cancer cell death in neuroblastoma

Neuroblastoma is a cancer that develops in nerve tissue, most commonly in the glands around the kidneys. The gene MYCN is overexpressed in 20-25% of neuroblastoma, and MYCN-amplified neuroblastoma contributes to a considerable percentage of pediatric cancer-related deaths.

24 Feb 2021

New platform can help treat neurodegenerative diseases through regenerative medicine

Imagine if surgeons could transplant healthy neurons into patients living with neurodegenerative diseases or brain and spinal cord injuries.

24 Feb 2021

Long-lasting B cells do not recognize emerging SARS-CoV-2 variants, shows study

A new analysis of B cells and more than 1,000 different monoclonal antibodies from 8 patients with COVID-19 shows that, contrary to previous hypotheses, protective B cell responses to the SARS-CoV-2 spike protein remain stable and continue to evolve over a 5-month period, many months after the initial period of active viral replication.

23 Feb 2021

COVID-19 may alter host proteins to cause autoimmunity

To better understand the transient and chronic autoimmune symptoms caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, researchers from Memorial Sloan Kettering Cancer Center, Guizhou Medical University, and biotech company Curandis embarked on an endeavor to establish a comprehensive autoantigenome for COVID19.

23 Feb 2021

Sheep model may help address fertility problems in women

A Texas A&M AgriLife study with sheep may soon help address fertility problems in women, if it can discover ways to break the chain of generational transfer of polycystic ovary syndrome, PCOS -- one of the most common infertility disorders.

23 Feb 2021

SARS-CoV-2 variants emerge during humoral immunity phase of acute COVID-19

A new preprint research paper posted to the bioRxiv server reports the rapid emergence of variants within an infected individual. The evolution of the virus within an infected host is not excluded by the close similarity between the consensus sequences of single-person SARS-CoV-2, since the number of viral copies is at its peak soon after infection occurs and before the host develops adaptive immunity.

23 Feb 2021

Two potent SARS-CoV-2 neutralizing antibodies effective against B.1.351 and B.1.1.7 variants

By analyzing the cryoEM structures of antibodies against the SARS-CoV-2 virus, researchers report that the neutralizing capabilities of two antibodies are not affected by new strains as these antibodies target regions of the virus away from the ACE2 binding regions.

23 Feb 2021

TBE patients continue to be affected by long-term problems

Impaired memory, reduced motivation, and declining motor skills. These are some of the problems that may persist several years after people contract tick-borne encephalitis, a University of Gothenburg thesis shows.

23 Feb 2021

Largescale antibody testing could lower the scale of COVID-19 pandemic

Research from Queen's University Belfast suggests that largescale antibody testing could lower social activity and thus contagion of COVID-19 (Coronavirus).

23 Feb 2021

Research predicts which mammal species can spread SARS-CoV-2

Scientists worldwide are fighting to contain the ongoing COVID-19 pandemic, which has already claimed more than 2.48 million lives. Preventing spillback infections is essential to containing the pandemic. To do so, it is vital to understand the nature of the virus, i.e., its susceptibility to a range of hosts.

23 Feb 2021

Slight differences can help distinguish between two similar pediatric brain conditions

Slight differences in clinical features can help physicians distinguish between two rare but similar forms of autoimmune brain inflammation in children, a new study by UT Southwestern scientists suggests.

23 Feb 2021

Study reveals new routes to potential treatments for chronic inflammatory conditions

Inflammatory lung diseases such as asthma, COPD and, most recently, COVID-19, have proven difficult to treat.

23 Feb 2021

New surgical procedure reduces the rate of recurrent strokes among atherosclerotic patients

A surgical procedure advanced and studied by vascular neurosurgeons at Cedars-Sinai dramatically reduced the rate of recurrent strokes among patients with atherosclerotic disease, a new study shows.

23 Feb 2021

Key mutation sites in the SARS-CoV-2 spike protein modulate antibody and ACE2 affinity

A paper recently uploaded to the preprint server bioRxiv by researchers at Chapman University in California (Feb 22nd, 2021) utilized computational methods to screen severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mutants for affinity with the angiotensin-converting enzyme 2 (ACE2) receptor and monoclonal antibodies REG10987 and REG10933.

23 Feb 2021

Innate immune system overreacts in patients with severe COVID-19

In patients with severe COVID-19, the innate immune system overreacts. This overreaction may underlie the formation of blood clots (thrombi) and deterioration in oxygen saturation that affect the patients.

23 Feb 2021

SARS-CoV-2 mutations allow escape from clinical monoclonal antibodies

A new research paper recently uploaded to the preprint server bioRxiv by Jesse D. Bloom et al. (22nd Feb 2021) aims to map all of the currently circulating SARS-CoV-2 lineages with resistance towards LY-CoV555 and LY-CoV016, and document the specific mutations that confer resistance, ultimately suggesting that future monoclonal antibody cocktails should target a more diverse range of epitopes.

23 Feb 2021

GSK-3 inhibitors show promise in treating coronavirus infections

Researchers in the United States have suggested a new approach to treating infection with coronaviruses such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).

23 Feb 2021

Glycan switch may explain why SARS-CoV-2 causes such variable symptoms

Researchers in Portugal have provided evidence that might explain why infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes mild or even asymptomatic illness in some individuals, but severe coronavirus disease 2019 (COVID-19) in others.

23 Feb 2021

Limiting the release of fat into the bloodstream during heart failure could help improve outcomes

University of Alberta researchers have found that limiting the amount of fat the body releases into the bloodstream from fat cells during heart failure could help improve outcomes for patients.

23 Feb 2021

New rapid diagnostic tests can differentiate between COVID-19 variants and multiple viruses

University of Minnesota Medical School researchers have developed two new rapid diagnostic tests for COVID-19 - one to detect COVID-19 variants and one to help differentiate with other illnesses that have COVID-19-like symptoms.

23 Feb 2021

Medical Research News

Study: Abundance of iron can drive cancer cell death in neuroblastoma

New platform can help treat neurodegenerative diseases through regenerative medicine

Long-lasting B cells do not recognize emerging SARS-CoV-2 variants, shows study

COVID-19 may alter host proteins to cause autoimmunity

Sheep model may help address fertility problems in women

SARS-CoV-2 variants emerge during humoral immunity phase of acute COVID-19

Two potent SARS-CoV-2 neutralizing antibodies effective against B.1.351 and B.1.1.7 variants

TBE patients continue to be affected by long-term problems

Largescale antibody testing could lower the scale of COVID-19 pandemic

Research predicts which mammal species can spread SARS-CoV-2

Slight differences can help distinguish between two similar pediatric brain conditions

Study reveals new routes to potential treatments for chronic inflammatory conditions

New surgical procedure reduces the rate of recurrent strokes among atherosclerotic patients

Key mutation sites in the SARS-CoV-2 spike protein modulate antibody and ACE2 affinity

Innate immune system overreacts in patients with severe COVID-19

SARS-CoV-2 mutations allow escape from clinical monoclonal antibodies

GSK-3 inhibitors show promise in treating coronavirus infections

Glycan switch may explain why SARS-CoV-2 causes such variable symptoms

Limiting the release of fat into the bloodstream during heart failure could help improve outcomes

New rapid diagnostic tests can differentiate between COVID-19 variants and multiple viruses

Advancing Menopause Care: Non-Hormonal Treatments for Vasomotor Symptoms

Building quality into drug development for safer, faster medicines

How Pulp Fixin Is Turning Paper into High-Performance Sustainable Labware

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