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New approach to mapping viral mutations that escape antibodies used to treat COVID-19

A new approach to mapping viral mutations that "escape" leading clinical antibodies has revealed mutations in the SARS-CoV-2 virus that allow it to evade treatments, including a single amino-acid mutation that fully escapes Regeneron's antibody cocktail.

26 Jan 2021

New discovery could lead to faster and more effective treatments for chronic health complications

A world-first discovery by researchers at Monash University and The University of Queensland could lead to faster and more effective treatments for chronic health complications, such as cardiovascular disease and cancer, with 'fluorescent' in vivo biosensors.

26 Jan 2021

Prostate cancer: Drug-resistant, metastasis-causing cells can produce exponentially growing tumors

The cover for issue 1 of Oncotarget features Figure 2, "Results in clinical trials," published in "Drug resistant cells with very large proliferative potential grow exponentially in metastatic prostate cancer" by Blagoev, et al. which reported that most metastatic cancers develop drug resistance during treatment and continue to grow, driven by a subpopulation of cancer cells unresponsive to the therapy being administered.

26 Jan 2021

Machine learning identifies patterns of maternal autoantibodies associated with autism

Using machine learning, researchers at the UC Davis MIND Institute have identified several patterns of maternal autoantibodies highly associated with the diagnosis and severity of autism.

26 Jan 2021

Researchers develop method for presymptomatic COVID-19 detection

An encouraging new study by researchers at University College London, UK, reports the potential of a form of COVID-19 testing which can detect presymptomatic cases.

26 Jan 2021

Astrocytes might be a potential new target to better treat epilepsy

A significant number of epilepsy patients does not respond to currently available drugs. A collaboration between researchers in Japan and at the Heinrich Heine University Düsseldorf now addressed a cell type in the brain that has so far not received much attention in epilepsy therapy.

26 Jan 2021

Codon frequency optimization shows SARS-CoV-2 antiviral potential

A study conducted by researchers in the US has revealed that optimization of codon for bacterial expression causes the production of an inactive enzyme non-structural protein 12 (Nsp12), a catalytic subunit of RNA-dependent RNA polymerase of SARS-CoV-2.

26 Jan 2021

Researchers engineer antibody that broadly neutralizes a range of clade 1 sarbecoviruses

Researchers have engineered an antibody that neutralizes SARS-CoV-2 with a potency that "rivals" current lead SARS-CoV-2 clinical neutralizing antibodies, and that also broadly neutralizes a range of clade 1 sarbecoviruses.

26 Jan 2021

Five-day regimen of radiotherapy safe, effective for men with high-risk forms of prostate cancer

A study led by researchers at the UCLA Jonsson Comprehensive Cancer Center found shortening a traditional 45-day course of radiation to a five-day course delivered in larger doses is safe and as effective as conventional radiation for men with high-risk forms of prostate cancer.

26 Jan 2021

Mutations in SARS-CoV-2 spike proteolytic cleavage sites may alter transmission dynamics

A study conducted by researchers at the University of Kentucky and the Washington University School of Medicine in the USA has revealed that mutations in the proteolytic cleavage site within the S2 subunit can alter the processing of the SARS-CoV-2 spike protein, affecting viral entry into host cells.

26 Jan 2021

Drug intervention may prevent heart damage caused by chemotherapy

There could be an intervention on the horizon to help prevent heart damage caused by the common chemotherapy drug doxorubicin, new research suggests.

26 Jan 2021

Diabetes and glucose levels tied to increased risk of COVID-19 death

Researchers at Xijing Hospital, Fourth Military Medical University, Xi’an, China, found that diabetes and on-admission glucose levels may increase the risk of COVID-19 mortality.

26 Jan 2021

SARS-CoV-2 rapidly adapts to Vero E6 cell culture propagation

Researchers at the Erasmus Medical Centre in the Netherlands and the University of Illinois at Urbana-Champaign in the US found that SARS-CoV-2 rapidly adapts to Vero E6 cell culture propagation and that this can be prevented by using cell lines with an active serine protease-mediated entry pathway.

26 Jan 2021

Study shows several peridomestic mammal species are potential spreaders of SARS-CoV-2

Researchers from the US and Australia show that several common peridomestic species (including deer mice, striped skunks and bushy-tailed woodrats) are amenable to infection with SARS-CoV-2.

26 Jan 2021

New UK SARS-CoV-2 variant circulating in US since November, says study

A new study by researchers at the Department of Ecology and Evolutionary Biology, University of Arizona, showed that the new variant has circulated in the US since November.

26 Jan 2021

New SARS-CoV-2 variant must be curbed to protect UK health services, warn experts

A new research project called REACT-1 – launched by researchers at the Imperial College London, Imperial College Healthcare NHS Trust, and Ipsos MORI – has aimed to better understand the dynamics of SARS-CoV-2’s viral spread across the UK.

26 Jan 2021

Accelerating vaccine rollout may provide greatest reduction in COVID-19 mortality

A thought-provoking preprint research paper posted to the medRxiv server suggests that among several factors that could potentially contribute to the design of an optimal vaccine strategy aimed at the most significant possible reduction in COVID-19 mortality, timing is likely to be the most important factor.

26 Jan 2021

Recombinant SARS-CoV-2 protein vaccine less immunogenic but more antigenic than expected

Now, a new preprint research paper posted to the medRxiv server presents preliminary results of a stabilized SARS-CoV-2 pre-fusion spike protein vaccine expressed in a baculovirus system (CoV2 preS dTM), with two different adjuvant formulations.

26 Jan 2021

B.1.1.7 variant and healthcare workers’ travel worry

Recently a team of researchers from Saudi Arabia, the United Arab Emirates, and the United States assessed travel-related anxiety in healthcare workers (HCWs) considering the emergence of new variants caused by SARS-CoV-2 mutations.

25 Jan 2021

Research shows immediate phase of blood vessel restructuring after aneurysm

Hitting a pothole on the road in just the wrong way might create a bulge on the tire, a weakened spot that will almost certainly lead to an eventual flat tire. But what if that tire could immediately begin reknitting its rubber, reinforcing the bulge and preventing it from bursting?

25 Jan 2021

Medical Research News

New approach to mapping viral mutations that escape antibodies used to treat COVID-19

New discovery could lead to faster and more effective treatments for chronic health complications

Prostate cancer: Drug-resistant, metastasis-causing cells can produce exponentially growing tumors

Machine learning identifies patterns of maternal autoantibodies associated with autism

Researchers develop method for presymptomatic COVID-19 detection

Astrocytes might be a potential new target to better treat epilepsy

Codon frequency optimization shows SARS-CoV-2 antiviral potential

Researchers engineer antibody that broadly neutralizes a range of clade 1 sarbecoviruses

Five-day regimen of radiotherapy safe, effective for men with high-risk forms of prostate cancer

Mutations in SARS-CoV-2 spike proteolytic cleavage sites may alter transmission dynamics

Drug intervention may prevent heart damage caused by chemotherapy

Diabetes and glucose levels tied to increased risk of COVID-19 death

SARS-CoV-2 rapidly adapts to Vero E6 cell culture propagation

Study shows several peridomestic mammal species are potential spreaders of SARS-CoV-2

New UK SARS-CoV-2 variant circulating in US since November, says study

New SARS-CoV-2 variant must be curbed to protect UK health services, warn experts

Accelerating vaccine rollout may provide greatest reduction in COVID-19 mortality

Recombinant SARS-CoV-2 protein vaccine less immunogenic but more antigenic than expected

B.1.1.7 variant and healthcare workers’ travel worry

Research shows immediate phase of blood vessel restructuring after aneurysm

Membrane proteins in focus: Turning high-risk targets into routine workflows

How metabolic phenotyping can detect viral infections in minutes

Directed enzyme evolution and the Nobel Prize: Making enzymes evolve in the lab

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