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Research shows a unique T cell receptor repertoire in MIS-C patients

Children with coronavirus disease 2019 (COVID-19) sometimes develop the Multisystem Inflammatory Syndrome in Children (MIS-C), which is associated with high morbidity. The underlying T-cell associated mechanism is described by researchers in a new study published on the preprint server bioRxiv in November 2020, as a response to superantigen activation.

11 Nov 2020

Men and women may require different brain tumor therapy, study finds

The current study shows that the sex differences in the tumor phenotype vary with the effect of the enhancer regulatory molecule bound to Brd4 on the course of stem cell-like differentiation in male and female GBM cells. Inhibition of Brd4 by genetic and pharmacological factors also varies in males and females, both in vivo and in vitro.

11 Nov 2020

Researchers find a better way to block asthma triggers

Every day, ten Americans die from asthma. While quick-acting inhalers and medications can reduce inflammation during an asthma attack, people with asthma have few tools to prevent the next attack from coming.

11 Nov 2020

Pitt neuroscientists uncover additional complexities behind sensation of pain from light touch

Researchers from the Pittsburgh Center for Pain Research at the University of Pittsburgh School of Medicine announced today in the journal Neuron that they've uncovered additional complexities behind mechanical allodynia--the sensation of pain from innocuous stimuli, such as light touch.

11 Nov 2020

Spain's annual life expectancy at birth dropped due to COVID-19 pandemic

Spain's annual life expectancy at birth dropped by 0.9 years between 2019 and the annual period up until July 2020 due to the COVID-19 pandemic, according to a new study published this week in the open-access journal PLOS ONE by Sergi Trias-Llimos of the Center for Demographic Studies, Spain, and colleagues.

11 Nov 2020

Behavioral responses to COVID-19 differ by age, study shows

A new study from the USC Leonard Davis School of Gerontology shows that the behavioral responses to COVID-19 differed by age.

11 Nov 2020

Study examines the impact of natural disasters on suicide rates

Disasters like hurricanes and tornadoes are occurring with increasing frequency and severity across the globe. In addition to impacting local communities, infrastructure and the economy, these disasters also can lead to severe emotional distress and anxiety for those living in their paths.

11 Nov 2020

Discovery of novel hidden gene in SARS-CoV-2

A team of researchers from Germany, Taiwan, and the United States has identified and characterized a new hidden gene in SARS-CoV-2 that is also present in Guangxi pangolin coronaviruses – though, curiously, absent in closely related pangolin and bat coronaviruses.

11 Nov 2020

Blood biomarker may predict prognosis, recovery from stroke

Researchers at Mayo Clinic in Florida and collaborators have found that a biomarker in the blood may determine the extent of brain injury from different types of strokes and predict prognosis in these patients.

11 Nov 2020

Smell and taste changes in general population may indicate COVID-19 spread

Self-reports of smell and taste changes provide earlier markers of the spread of infection of SARS-CoV-2 than current governmental indicators, according to an international team of researchers.

11 Nov 2020

Spike-based DNA vaccine shows excellent protection against SARS-CoV-2 in a hamster model

A study conducted at the United States Army Research Institute of Infectious Diseases shows how a relatively simple full-length DNA vaccine against spike glycoprotein of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can elicit neutralizing antibody response in an animal model – even after a single shot with simple jet injection technique.

11 Nov 2020

Researchers link balance dysfunction after traumatic brain injury with diminished sensory acuity

Kessler Foundation researchers have linked balance dysfunction in individuals with traumatic brain injury with diminished sensory acuity.

11 Nov 2020

Teledermatology improves access to care, reduces consult time

A new study from researchers in the Perelman School of Medicine at the University of Pennsylvania and Independence Blue Cross shows that when patients' primary care doctors were able to photograph areas of concern and share them with dermatologists, the response time for a consultation dropped from almost 84 days to under five hours.

11 Nov 2020

Research reveals uncertainty in how to care for patients with certain type of heart attack

There are several different types of heart attacks, which occur when blood flow to the heart is blocked or reduced. New research by investigators at Massachusetts General Hospital reveals considerable uncertainty in how to care for patients with one type.

11 Nov 2020

MU researcher develops procedures for defining the preclinical stages of Alzheimer's disease

Both of Andrew Kiselica's grandfathers developed dementia when he was in graduate school. As Kiselica was going through neuropsychology training in graduate school, he saw his mother's father become unable to walk or speak due to severe dementia.

11 Nov 2020

Host genetic "super-variants" may increase COVID-19 death risk

Researchers at Yale University have identified genetic variants among people of white British ancestry that may increase the risk of dying from coronavirus disease 2019 (COVID-19) – the illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

11 Nov 2020

Rheumatoid arthritis may increase risk of dying from COVID-19

Researchers in New Zealand and Australia have conducted a study showing that people with rheumatoid arthritis may be at an increased risk of death if they develop coronavirus disease 2019 (COVID-19) after becoming infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

11 Nov 2020

Children's sleep behaviors linked to gray matter volume with implications for academic performance, IQ

Children who sleep better (that is, those who wake up less during night) and those who wake up earlier have more grey matter in their brains (specifically, in eight cortical regions and in the hippocampus), perform better academically, and have a higher level of intelligence (IQ).

11 Nov 2020

Low prevalence of SARS-CoV-2 specific antibodies in Lubbock, Texas

A recent study published in the Journal of Primary Care and Community Health has assessed the prevalence of antibodies developed specifically against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in front-line workers in Lubbock, Texas. According to the study findings, immunoglobulin G (IgG)-specific anti-SARS-CoV-2 antibodies have been detected in only 0.73% of the participants.

11 Nov 2020

Research tracks humoral immunity response over eight months post COVID-19 infection

Researchers from Chongqing Medical University have tried to answer one of the burning questions regarding the longevity of immune response to coronavirus disease 2019 (COVID-19): How long does immunity last after infection? Their study looked at the lasting effects and continued immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) over eight months after recovery from the infection.

11 Nov 2020