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Study reveals new insights into how UV light triggers kidney inflammation in lupus patients

A new collaborative study from researchers at the Geisel School of Medicine at Dartmouth and the University of Washington (UW) and published in the Proceedings of the National Academy of Sciences, reveals unexpected insights into how skin exposure to ultraviolet light can worsen clinical symptoms in autoimmune diseases such as lupus.

22 Jan 2021

Patient-specific model is needed to understand cancer cells and their impacts

Despite cancer being a leading cause of death worldwide, treatment options for many types of cancers remain limited. This is partly due to the in vitro tools used to model cancers, which cannot adequately predict the behavior of a cancer or its sensitivity to drugs.

22 Jan 2021

Genomic test has lower prognostic accuracy in minority patients with breast cancer

Black women have higher recurrence and mortality rates than non-Hispanic white women for certain types of breast cancer, according to a University of Illinois Chicago researcher's study published recently in JAMA Oncology.

22 Jan 2021

Researchers develop comprehensive framework to classify small-cell lung cancer

Researchers from The University of Texas MD Anderson Cancer Center have developed the first comprehensive framework to classify small-cell lung cancer (SCLC) into four unique subtypes, based on gene expression, and have identified potential therapeutic targets for each type in a study published today in Cancer Cell.

22 Jan 2021

Simple count of social determinants of health may help predict patients' fatal heart disease risks

Doctors may be able to predict their patients' risks of fatal coronary heart disease more accurately by taking into account the number of adverse social factors affecting them, according to a new study led by researchers at Weill Cornell Medicine and NewYork-Presbyterian.

22 Jan 2021

New study helps understand molecular profile of tumors in cancer patients

Researchers from the University Hospitals in Zurich and Basel, ETH Zurich, University of Zurich and the pharmaceutical company Roche have set out to improve cancer diagnostics by developing a platform of state-of-the-art molecular biology methods.

21 Jan 2021

Mitochondrial mutation linked to elevated diabetes risk in Japanese men

A new study of Type 2 diabetes in Japanese populations has uncovered a previously uncharacterized genetic variant that puts male carriers at greater risk for the disease, as well as the mechanism by which it does so.

21 Jan 2021

Prioritizing older adults for COVID-19 vaccination will save more lives

Vaccinating older adults for COVID-19 first will save substantially more U.S. lives than prioritizing other age groups, and the slower the vaccine rollout and more widespread the virus, the more critical it is to bring them to the front of the line.

21 Jan 2021

New model shows key role of innate immunity in controlling COVID-19 viral load

Since SARS-CoV-2 was identified in December 2019, researchers have worked feverishly to study the novel coronavirus. Although much knowledge has been gained, scientists still have a lot to learn about how SARS-CoV-2 interacts with the human body, and how the immune system fights it.

21 Jan 2021

New data on impact of spike mutations and B117 UK variant on neutralization by mAbs and sera

A recent paper by British and Dutch scientists, currently available on the bioRxiv* preprint server, shows that the neutralizing activity of monoclonal antibodies can be dramatically reduced by mutations of the SARS-CoV-2 spike glycoprotein – unlike polyclonal antibodies generated after natural infection that remain active regardless of any introduced amino acid changes.

21 Jan 2021

SARS-CoV-2 variants appear to arise independently of local transmission

Researchers at the University of Michigan in the United States have cautioned against only using within-host minor genetic variations to resolve the genomic epidemiology of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).

21 Jan 2021

Pfizer-BioNTech vaccine shows reduced neutralization potential against SARS-CoV-2 B.1.1.7 spike variant

Researchers in the UK have conducted a study assessing the efficacy of the Pfizer-BioNTech COVID-19 vaccine BNT162b2 against the new variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).

21 Jan 2021

Study: Vast majority of U.S. infants may be suffering from gut microbiome deficiency

A new peer-reviewed study reveals that the vast majority of U.S. infants may be suffering from a substantial deficiency in an important bacterium key to breast milk utilization and immune system development, as well as protection against gut pathogens linked to common newborn conditions such as colic and diaper rash.

21 Jan 2021

Positive messages could potentially increase mask usage during the pandemic

Many organizations are looking at effective ways to communicate the importance of wearing a mask, especially as highly transmissible new strains of coronavirus threaten to cause a surge in infections.

21 Jan 2021

Randomized trials could help clarify uncertainties around reopening schools safely

Schools are closing again in response to surging levels of COVID-19 infection, but staging randomised trials when students eventually return could help to clarify uncertainties around when we should send children back to the classroom, according to a new study.

21 Jan 2021

Researchers simulate tailgating to examine the impact of excessive eating and drinking

The NFL playoffs are underway, and fans are finding ways to simulate tailgating during the COVID-19 pandemic. Football watch parties are synonymous with eating fatty foods and drinking alcohol. Have you ever wondered what all of that eating and drinking does to your body?

21 Jan 2021

Older age may offer a buffer against negative feelings brought on by the pandemic

Older adults are managing the stress of the coronavirus pandemic better than younger adults, reporting less depression and anxiety despite also experiencing greater general concern about COVID-19, according to a study recently published by researchers at the UConn School of Nursing.

21 Jan 2021

Dynamic, customized treatment approaches for gastroesophageal cancers may improve survival rates

A phase 2 clinical trial providing personalized treatments based on the genetic profile of metastatic tumors in gastroesophageal cancers has found that using customized treatment approaches, and adapting them over time as tumors become resistant, led to higher rates of survival compared to historical controls.

21 Jan 2021

COVID-19, influenza and suicide are responsible for deaths of ICE detainees

Thirty-five people have died in the custody of U.S. Immigration and Customs Enforcement (ICE) since April 2018, with a seven-fold increase in deaths even as the average daily population decreased by nearly a third between 2019 and 2020, a new USC study shows.

21 Jan 2021

New drug target valid for breast cancer as well as lymphoma

One more piece of the puzzle has fallen into place behind a new drug whose anti-cancer potential was developed at the University of Alberta and is set to begin human trials this year, thanks to newly published research.

21 Jan 2021

Medical Research News

Study reveals new insights into how UV light triggers kidney inflammation in lupus patients

Patient-specific model is needed to understand cancer cells and their impacts

Genomic test has lower prognostic accuracy in minority patients with breast cancer

Researchers develop comprehensive framework to classify small-cell lung cancer

Simple count of social determinants of health may help predict patients' fatal heart disease risks

New study helps understand molecular profile of tumors in cancer patients

Mitochondrial mutation linked to elevated diabetes risk in Japanese men

Prioritizing older adults for COVID-19 vaccination will save more lives

New model shows key role of innate immunity in controlling COVID-19 viral load

New data on impact of spike mutations and B117 UK variant on neutralization by mAbs and sera

SARS-CoV-2 variants appear to arise independently of local transmission

Pfizer-BioNTech vaccine shows reduced neutralization potential against SARS-CoV-2 B.1.1.7 spike variant

Study: Vast majority of U.S. infants may be suffering from gut microbiome deficiency

Positive messages could potentially increase mask usage during the pandemic

Randomized trials could help clarify uncertainties around reopening schools safely

Researchers simulate tailgating to examine the impact of excessive eating and drinking

Older age may offer a buffer against negative feelings brought on by the pandemic

Dynamic, customized treatment approaches for gastroesophageal cancers may improve survival rates

COVID-19, influenza and suicide are responsible for deaths of ICE detainees

New drug target valid for breast cancer as well as lymphoma

Membrane proteins in focus: Turning high-risk targets into routine workflows

How metabolic phenotyping can detect viral infections in minutes

Directed enzyme evolution and the Nobel Prize: Making enzymes evolve in the lab

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