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Intranasal vaccination effectively reduces viral shedding of SARS-CoV-2 in monkeys

A new preprint that appeared on the bioRxiv server reports that intranasal vaccination with the D614G variant of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in rhesus monkeys reduces viral shedding. This is an experiment in non-human primates (NHP), and its extrapolation to humans is unclear as yet.

12 Jan 2021

Structure of SARS-CoV-2 cytoplasmic tail uncovered

The virus's cytosolic tail also interacts with the host cell to promote its entry into the endoplasmic reticulum (ER). A new study appearing on the bioRxiv preprint server elucidates the conformation of this region of the virus, which will help understand how its form is related to its function in viral entry.

12 Jan 2021

Effect of mutations in the South African SARS-CoV-2 variant on transmission and neutralization

One such strain is the South African 501.V2 and UK B1.1.7 strains, which have been isolated from many countries and seem to spread faster than the ancestral strain. A preprint that recently appeared on the bioRxiv server reports the computational structure of this strain and the possible effect of the mutations on infectivity and neutralization.

12 Jan 2021

Bleeding disorder linked to poor clinical outcomes in COVID-19 patients

The novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is the pathogen responsible for the ongoing coronavirus disease 2019 (COVID-19) pandemic. Approximately 20-55% of hospitalized COVID-19 patients are reported to have deranged hemostatic laboratory parameters, which suggests coagulopathy.

12 Jan 2021

Researchers discover a new approach to inhibit intrahepatic cholangiocarcinoma

Reprogramming the rich connective tissue microenvironment of a liver cancer known as intrahepatic cholangiocarcinoma (ICC) inhibits its progression and resistance to standard chemotherapy in animal models, researchers from Massachusetts General Hospital have found.

12 Jan 2021

Mothers with multiple children report worse sleep patterns

Mothers with multiple children report more fragmented sleep than mothers of a single child, but the number of children in a family doesn't seem to affect the quality of sleep for fathers, according to a study from McGill University.

12 Jan 2021

Antigenic "supersite" could improve design of COVID-19 vaccines

Researchers in the United States have defined an antigenic “supersite” within the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that could have important implications for the design of vaccines to protect against coronavirus disease 2019 (COVID-19).

12 Jan 2021

Study reveals rising risk of mental health problems among COVID-19 health care professionals

The daily toll of COVID-19, as measured by new cases and the growing number of deaths, overlooks a shadowy set of casualties: the rising risk of mental health problems among health care professionals working on the frontlines of the pandemic.

12 Jan 2021

Study investigates the metabolites involved in growth and spread of melanoma

The first step in treating cancer is understanding how it starts, grows and spreads throughout the body. A relatively new cancer research approach is the study of metabolites, the products of different steps in cancer cell metabolism, and how those substances interact.

12 Jan 2021

Stimulation method helps some people with spinal cord injury to regain hand and arm mobility

Almost 18,000 Americans experience traumatic spinal cord injuries every year. Many of these people are unable to use their hands and arms and can't do everyday tasks such as eating, grooming or drinking water without help.

12 Jan 2021

Hypoxia signaling pathway could lead to COVID-19 treatments

Researchers in Spain have demonstrated that studying the hypoxia signaling pathway could provide opportunities for treating coronavirus disease 2019 (COVID-19).

12 Jan 2021

Researchers call for stronger regulations to reduce health burden of smokeless tobacco

Researchers at the University of York are calling for more stringent regulatory measures to reduce the health burden of smokeless tobacco, a product often found in UK stores without the proper health warnings and as a result of illicit trading.

12 Jan 2021

K-State medical director contributes to research on SARS-CoV-2 transmission and quarantine periods

Kyle Goerl, the medical director of Kansas State University's Lafene Health Center, is part of a collaborative team that is providing research-based guidance during the COVID-19 pandemic.

12 Jan 2021

$Incidence of osteoporotic hip fractures expected to escalate in some Eurasian countries$

Incidence of osteoporotic hip fractures expected to escalate in some Eurasian countries

A detailed analysis of the burden of osteoporosis in eight Eurasian countries has found that osteoporosis is a significant and growing health problem in the region that will escalate in the future due to expected demographic changes.

12 Jan 2021

Poor gut health may adversely affect COVID-19 prognosis

People infected with COVID-19 experience a wide range of symptoms and severities, the most commonly reported including high fevers and respiratory problems.

12 Jan 2021

Study examines the role of gut microbes in anorexia

You are likely familiar with the serious consequences of anorexia for those who experience it, but you might not be aware that the disorder may not be purely psychological.

12 Jan 2021

Metabolites may be predictive indicators of patients at risk for recurrent major depression

Researchers at University of California San Diego School of Medicine, in collaboration with Dutch scientists, have found that certain metabolites - small molecules produced by the process of metabolism - may be predictive indicators for persons at risk for recurrent major depressive disorder.

12 Jan 2021

Study: Sugar substitute doesn't lead to the development of diabetes in healthy adults

For those trying to live a healthy lifestyle, the choice between sugar and artificial sweeteners such as saccharin can be confusing.

12 Jan 2021

Researchers study the effectiveness of FEND product to improve airway hygiene

In a paper published in Molecular Frontiers Journal, researchers from Cambridge, Massachusetts and Bangalore, India study the effectiveness of FEND product to significantly improve airway hygiene by reducing and suppressing respiratory droplets potentially containing airborne pathogens and other contaminants.

12 Jan 2021

Clinicians at leading cardiac center report burnout and high levels of distress

More than half the clinicians surveyed at the Peter Munk Cardiac Centre reported burnout and high levels of distress according to a series of studies published today in the Canadian Medical Association Journal Open.

12 Jan 2021

Medical Research News

Intranasal vaccination effectively reduces viral shedding of SARS-CoV-2 in monkeys

Structure of SARS-CoV-2 cytoplasmic tail uncovered

Effect of mutations in the South African SARS-CoV-2 variant on transmission and neutralization

Bleeding disorder linked to poor clinical outcomes in COVID-19 patients

Researchers discover a new approach to inhibit intrahepatic cholangiocarcinoma

Mothers with multiple children report worse sleep patterns

Antigenic "supersite" could improve design of COVID-19 vaccines

Study reveals rising risk of mental health problems among COVID-19 health care professionals

Study investigates the metabolites involved in growth and spread of melanoma

Stimulation method helps some people with spinal cord injury to regain hand and arm mobility

Hypoxia signaling pathway could lead to COVID-19 treatments

Researchers call for stronger regulations to reduce health burden of smokeless tobacco

K-State medical director contributes to research on SARS-CoV-2 transmission and quarantine periods

Incidence of osteoporotic hip fractures expected to escalate in some Eurasian countries

Poor gut health may adversely affect COVID-19 prognosis

Study examines the role of gut microbes in anorexia

Metabolites may be predictive indicators of patients at risk for recurrent major depression

Study: Sugar substitute doesn't lead to the development of diabetes in healthy adults

Researchers study the effectiveness of FEND product to improve airway hygiene

Clinicians at leading cardiac center report burnout and high levels of distress

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

Bringing real-time analytics to downstream bioprocess monitoring

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