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New drug combinations could help overcome genetic immunotherapy resistance

A new study from researchers at the UCLA Jonsson Comprehensive Cancer Center helps explain how disruptions in genes can lead to the resistance to one of the leading immunotherapies, PD-1 blockade, and how new drug combinations could help overcome resistance to the anti-PD-1 therapy in a mechanistically-based way.

28 May 2020

Researchers study the effect of major life events on wellbeing

Major life events such as marriage, death of a loved one or bankruptcy all affect our wellbeing. Now, for the first time, researchers have compared the differing impact of these events on the happiness and life satisfaction and how long that impact lasts.

28 May 2020

Adequate building ventilation can help tackle airborne transmission of Covid-19

Preventing airborne transmission of Covid-19 should be the next front of the battle against the virus, argue experts from the University of Surrey.

28 May 2020

Scientists create adenovirus that kills cancer cells

An adenovirus is now better able to target and kill cancer cells due to the addition of an RNA stabilizing element.

28 May 2020

Women and minorities inadequately represented in clinical trials for novel cardiometabolic drugs

Women and minorities, particularly African Americans, continue to be inadequately represented in clinical trials for novel cardiometabolic medications, with no evidence of improvement in enrollment numbers over the past decade, according to new research published last week in the Journal of the American Heart Association, an open-access journal of the American Heart Association.

28 May 2020

Transgenic mouse model of HLH may play key role in saving lives during COVID-19

A transgenic mouse developed at Cincinnati Children's to model the deadly childhood immune disease HLH (hemophagocytic lymphohistiocytosis) may play a key role in saving lives during the COVID-19 virus pandemic.

28 May 2020

Physical activity prevents the accumulation of damaged proteins and keeps muscles healthy

Researchers at the University of Copenhagen's Department of Nutrition, Exercise and Sports have demonstrated that physical activity prompts a clean-up of muscles as the protein Ubiquitin tags onto worn-out proteins, causing them to be degraded.

28 May 2020

Type 2 diabetes is more prevalent in American Indians and Alaska Natives

Type 2 diabetes (T2D) affects American Indians and Alaska Natives at approximately three times the rate of white Americans and is closely linked to the disproportionately high rates of cardiovascular diseases such as heart attacks and strokes, according to the American Heart Association Scientific Statement "Cardiovascular Health in American Indians and Alaska Natives," published today in the Association's flagship journal Circulation.

28 May 2020

Nearly 50% of COVID-19 patients have altered sense of tastes

Nearly half of individuals who contract COVID-19 experience changes in their sense of taste, a new analysis led by a University of Toledo researcher has found.

28 May 2020

Early exposure to anesthetics may cause alcohol use disorder in adolescents

Early exposure to anesthetics may make adolescents more susceptible to developing alcohol use disorder (AUD), according to new research from Binghamton University, State University of New York.

28 May 2020

New project launched to find novel treatments for rare genetic diseases

The University Carlos III Madrid, Almirall, S.A. and the MEDINA Foundation have launched a project to find new treatments for recessive dystrophic epidermolysis bullosa and other genetic diseases caused by nonsense mutations.

28 May 2020

Studies advance the understanding of sensory disconnection during sleep and anesthesia

During sleep and under anesthesia, we rarely respond to such external stimuli as sounds even though our brains remain highly active.

28 May 2020

Fluctuating estrogen levels could make alcohol more rewarding to women

Fluctuating estrogen levels may make alcohol more rewarding to female mice, according to new research in JNeurosci. Untangling the involved signaling pathways could unveil sex-based treatments for alcohol use disorders.

28 May 2020

Monash study confirms new approach to measure consciousness

An international study involving Monash physicists has confirmed a new approach to measure consciousness, potentially changing our understanding complex neurological problems.

28 May 2020

SCN study outlines impacts of targeted skills training on Canada’s regenerative medicine sector

Today, Canada’s Stem Cell Network (SCN) released a study entitled, Training Tomorrow’s Research Leaders, outlining the impacts of nearly 20 years of targeted skills training on Canada’s emergent regenerative medicine sector.

28 May 2020

Frog brain discovery may pave the way for repairing birth defects in humans

A team of researchers from Tufts University, Universitat de Valencia, and Harvard University has discovered that the brains of developing frog embryos damaged by nicotine exposure can be repaired by using “ionoceuticals” that can help in the recovery of bioelectric patterns in the embryo.

28 May 2020

Faulty ApoE4 gene increases risk for Alzheimer’s and for COVID-19

It has not been clear whether dementia worsens the infection or if it has resulted from the patient's old age and the severity of care home outbreaks. Now, a new study sheds light on the reason why people with dementia are at a high risk of developing severe disease caused by the coronavirus disease.

27 May 2020

Canadian study of COVID-19 patients admitted to ICUs finds lower overall mortality

A Canadian case series of all patients with COVID-19 admitted to six intensive care units (ICUs) in Metro Vancouver found patient outcomes were substantially better than reported in other jurisdictions. The paper is published in CMAJ.

27 May 2020

Is air pollution a risk factor for COVID-19 infection?

The COVID-19 pandemic began at the very end of 2019 in Wuhan city, Hubei province, China. However, its spread soon began to threaten the health of the whole country and then of the world, leading to nearly 5.7 million cases and over 355,000 dead as of today. A new study, published on the preprint server medRxiv* in May 2020, explores the effects of air pollution on COVID-19 infections in China.

27 May 2020

Research provides new evidence for potential blood-based biomarker for Alzheimer's

A potential blood-based biomarker for Alzheimer's and other neurodegenerative diseases seems even more promising thanks to new research from a Massachusetts General Hospital-led study.

27 May 2020