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Study helps predict which ovarian cancer patients will not benefit from immune-PARP combo

In patients with advanced ovarian cancer, a combination of drugs known as immune checkpoint inhibitors and PARP inhibitors can produce powerful remissions, clinical trials have shown, but up until now investigators haven't been able to predict which patients won't benefit from the treatment and should explore other options.

19 Mar 2020

Mental stress may be a stronger predictor of repeat heart attack

We all have stress in our lives--whether it's due to financial woes, work pressures, relationship issues, illness or even natural disasters or health crises like the emerging coronavirus.

19 Mar 2020

Study paves way for identifying ovarian cancer patients who will not benefit from combination therapy

A study suggests it may be possible to identify those who will not benefit from drug combination for advanced ovarian cancer.

19 Mar 2020

Mental stress may better predict repeat heart attack than physical stress

For heart attack survivors, psychological stress may better predict future heart attack or disease than physical stress.

19 Mar 2020

Hypertension-related deaths increase in the U.S across all age groups

While it typically has no symptoms, high blood pressure--or hypertension--has serious health consequences.

19 Mar 2020

Bacteria-trapping protein may contribute to breast cancer metastasis

The protein peptidyl arginine deiminase 4 (PAD4), which enables some immune cells to trap bacteria, promoted breast cancer metastasis in mice when expressed in cancer cells, according to data published in Molecular Cancer Research, a journal of the American Association for Cancer Research.

19 Mar 2020

People taking more steps daily found to have lower blood pressure

The smart watches seen on the wrists of roughly 1 in 5 Americans could be more than just a fun gimmick but a potentially useful research tool to track habitual physical activity levels.

19 Mar 2020

Statins may protect against heart damage caused by breast cancer therapies

Statins are widely used to lower cholesterol and prevent heart disease and related deaths, but can they also help guard against heart damage caused by certain breast cancer therapies?

19 Mar 2020

Homeless heart attack patients receive less treatment and are more likely to be readmitted

Homelessness has become a social crisis and public health problem around the world, affecting people of all ages. Most homeless people are at a disadvantage with few resources, and may or may not have adequate health insurance.

19 Mar 2020

Frailty plays a key role in outcomes following mitral valve procedures

Frailty measurements have become increasingly important in assessing surgical risk in patients with mitral valve disease, and research published online today in The Annals of Thoracic Surgery shows that frailty plays a significant role in outcomes following mitral valve procedures.

19 Mar 2020

More protein intake could cut the risk of developing atrial fibrillation in women

Women who ate slightly more than the recommended daily amount of protein were significantly less likely to develop atrial fibrillation

19 Mar 2020

Digestive symptoms are common in COVID-19 patients, study reveals

The American Journal of Gastroenterology published today a new study that reveals digestive symptoms, including diarrhea, are common in COVID-19 patients. The study comes from the Wuhan Medical Treatment Expert Group for COVID-19 in China.

19 Mar 2020

Identification of 'Hodor' in the gut lining highlights potential way to curb mosquito populations

The identification of an insect-specific metal-sensing receptor in the gut lining highlights a possible new way to curb populations of disease-transmitting insects such as mosquitoes.

18 Mar 2020

Singapore researchers find common therapeutic vulnerability for a deadly blood cancer

CML is a blood cancer that can be controlled by continuously taking an expensive type of medicine called a tyrosine kinase inhibitor (TKI). In almost all patients, stopping TKI treatment results in recurrence of CML.

18 Mar 2020

Targeting PI3Kβ alone and with combination therapy in PTEN-deficient tumors

The cover for issue 11 of Oncotarget features Figure 6, "Effects of AZD8186 in combination with anti-PD1 on syngeneic models," by Owusu-Brackett, et al.

18 Mar 2020

Viewpoint: Could infectious pathogens play a role in Alzheimer's disease?

For researchers investigating Alzheimer's Disease (AD), a devastating neurodegenerative illness afflicting close to 6 million Americans, it is the best and worst of times.

18 Mar 2020

Obese children more prone to anxiety, depression and shortening of life

Two studies published in the journals PLOS Medicine and BMC Medicine in March 2020 show that obesity in childhood is linked to a higher risk of future anxiety, depression, and death in early adult life compared to children in the general population. This could shape efforts to detect specific risk factors that predispose children to obesity and thus prevent it.

18 Mar 2020

Drug from scorpion venom could offer hope for children with fetal alcohol spectrum disorder

A research team led by Children's National Hospital faculty was able to "rescue" a pre-clinical model of fetal alcohol spectrum disorder in juvenile models, reversing motor skill deficits with the help of a novel drug derived from scorpion venom.

18 Mar 2020

Psychosis may be caused by problems with specialized nerve cells

A new Japanese study in mice published in the journal Nature indicates that the cause of the profound mental disturbance termed psychosis could be due to defects in the functioning of specialized nerve cells deep inside the brain, and due to some types of learning behavior. This could help understand how delusions arise in psychosis or schizophrenia, and eventually to develop therapies for these conditions.

18 Mar 2020

$FLS care effective for patients with fragility fractures$

FLS care effective for patients with fragility fractures

For patients with fragility fractures related to underlying bone weakness, a dedicated fracture liaison service can lower the risk of subsequent fractures, suggests a study in the March 18, 2020 issue of The Journal of Bone & Joint Surgery.

18 Mar 2020

Medical Research News

Study helps predict which ovarian cancer patients will not benefit from immune-PARP combo

Mental stress may be a stronger predictor of repeat heart attack

Study paves way for identifying ovarian cancer patients who will not benefit from combination therapy

Mental stress may better predict repeat heart attack than physical stress

Hypertension-related deaths increase in the U.S across all age groups

Bacteria-trapping protein may contribute to breast cancer metastasis

People taking more steps daily found to have lower blood pressure

Statins may protect against heart damage caused by breast cancer therapies

Homeless heart attack patients receive less treatment and are more likely to be readmitted

Frailty plays a key role in outcomes following mitral valve procedures

More protein intake could cut the risk of developing atrial fibrillation in women

Digestive symptoms are common in COVID-19 patients, study reveals

Identification of 'Hodor' in the gut lining highlights potential way to curb mosquito populations

Singapore researchers find common therapeutic vulnerability for a deadly blood cancer

Targeting PI3Kβ alone and with combination therapy in PTEN-deficient tumors

Viewpoint: Could infectious pathogens play a role in Alzheimer's disease?

Obese children more prone to anxiety, depression and shortening of life

Drug from scorpion venom could offer hope for children with fetal alcohol spectrum disorder

Psychosis may be caused by problems with specialized nerve cells

FLS care effective for patients with fragility fractures

Advancing brain microphysiological systems (bMPS)

PhD researcher at LifeArc

Unveiling Hidden Potential: Organoids for Disease Modeling in Neuroscience Research

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