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Compensatory neural connections stave off bipolar disorder onset

Patients at high genetic risk of bipolar disorder may be able to avert onset of the condition due to natural adaptive neuroplasticity that allows the brain to compensate for underlying network dysfunction associated with the condition, researchers report.

19 Jan 2016

$SIRIUS supports single-agent daratumumab in refractory multiple myeloma$

SIRIUS supports single-agent daratumumab in refractory multiple myeloma

Phase II trial results show that daratumumab monotherapy elicits responses and has a favourable adverse event profile in heavily-pretreated, refractory multiple myeloma patients.

19 Jan 2016

Stem cell transplantation of neurotrophic factors shows promise in ALS

Mesenchymal stem cells cultured to secrete neurotrophic factors can be administered to patients with amyotrophic lateral sclerosis without lasting unwanted effects and may have clinical benefits, indicates a phase I/II safety analysis study.

19 Jan 2016

Selexipag reduces clinical events in PAH patients

Selexipag, alone or in combination with other classes of pulmonary arterial hypertension medication, reduced the composite rate of disease complications and deaths among patients in a phase III trial.

19 Jan 2016

TG4010 vaccine promising in advanced NSCLC

Addition of the TG4010 vaccine to first-line chemotherapy improves outcomes in patients with advanced non-small-cell lung cancer, show the results of a placebo controlled trial.

19 Jan 2016

Common mortality causes prevail in epilepsy patients

A prospective, community-based study confirms that patients with epilepsy usually die of the same causes as other people.

19 Jan 2016

Best management unclear for patients needing carotid revascularisation

Research highlights the vulnerability of patients with symptomatic carotid stenosis to stroke while awaiting revascularisation.

19 Jan 2016

Citalopram of limited use for dementia-associated agitation

The use of citalopram for the treatment of agitation in Alzheimer’s disease may be limited to a small group of people with moderate agitation and low levels of cognitive impairment, study findings suggest.

19 Jan 2016

Anticholinesterase offers a ‘steadying hand’ to PD patients

The dementia drug rivastigmine may reduce the risk of falls in patients with Parkinson’s disease by improving gait stability, findings from the phase II ReSponD trial show.

19 Jan 2016

Weight loss may mark rapid Parkinson’s disease progression

Weight loss in patients with early Parkinson’s disease is associated with worsening motor function, research shows.

19 Jan 2016

Bradycardia does not increase cardiovascular disease risk

Bradycardia - a slower than normal heartbeat - does not increase the risk of developing cardiovascular disease, according to a study conducted by researchers at Wake Forest Baptist Medical Center. The study is published in the Jan.19 online edition of the Journal of American Medical Association Internal Medicine.

19 Jan 2016

Text message reminders may help reduce people’s blood pressure

The study, of over 1300 adults with high blood pressure in the Cape Town area, compared text message reminders and interactive text messaging to a control group receiving standard care. The results appear online in the American Heart Association journal Circulation.

19 Jan 2016

New diagnostic method shows COPD risk higher for women

Researchers from Lund University Sweden have through a new diagnostic method been able to show that the risk of developing Chronic Obstructive Pulmonary Disease could be twice as high for women as it is for men.

19 Jan 2016

WASF3 protein appears to be solid target for reducing cancer metastasis

A protein that is constantly expressed by cancer cells and quiescent in healthy ones appears to be a solid target for reducing cancer's ability to spread, scientists report.

19 Jan 2016

Researchers identify protein that could protect against toxic degeneration of cells in ALS

J. Gavin Daigle, a PhD candidate at the LSU Health New Orleans School of Graduate Studies, is the first author of a paper whose findings reveal another piece of the Amyotrophic Lateral Sclerosis (ALS) puzzle.

19 Jan 2016

GBI Research says COPD therapeutics pipeline lacks innovation

Analysis from business intelligence provider GBI Research - Frontier Pharma: Chronic Obstructive Pulmonary Disease (COPD) - Identifying and Commercializing First-in-Class Innovation - states that while currently-available drugs aim to manage the frequency and severity of symptoms associated with COPD, none have been shown to modify long-term disease progression.

19 Jan 2016

Rapastinel demonstrates pro-cognitive benefits in animal model of cognitive impairment

Allergan plc, a leading global pharmaceutical company, announced today that new data on the investigational medication rapastinel (GLYX-13) and its lack of impairment on cognitive function were published in the peer-reviewed journal Behavioural Brain Research.

19 Jan 2016

Age-related macular degeneration: an interview with Cathy Yelf, Macular Society

Age-related macular degeneration is a condition of the macula, a tiny area of the retina at the back of the eye. Your macula is only about the size of the grain of rice, that’s about four millimeters across.

19 Jan 2016

Phthalate DEHP could lead to weight gain

In cooperation with the Integrated Research and Treatment Center Adiposity Diseases at the University of Leipzig and the University Hospital Leipzig, researchers from the Helmholtz Centre for Environmental Research have now published a study in the PLOS ONE journal showing that the phthalate DEHP leads to weight gain and revealed the metabolic processes involved.

19 Jan 2016

Cash transfer programme increases child births at facilities, but fails to reduce maternal deaths

To reduce maternal and neo-natal deaths, India launched a cash transfer programme in 2005 that provides monetary incentives for women to give birth in health facilities instead of at home. While the programme successfully increased the use of health facilities for child birth, it did not reduce maternal deaths as much, especially in poor areas.

19 Jan 2016