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Vitamin D receptor activation slows cell overgrowth in pulmonary hypertension

The study demonstrates that activating the vitamin D receptor (VDR) with calcitriol suppresses cell proliferation in pulmonary arterial smooth muscle cells, potentially reducing disease severity in pulmonary arterial hypertension (PAH).

12 Nov 2024

Exercise promotes nerve growth at the cellular level

There's no doubt that exercise does a body good. Regular activity not only strengthens muscles but can bolster our bones, blood vessels, and immune system.

12 Nov 2024

Western diet accelerates endometriosis growth and disrupts gut health

This study found that a Western diet doubles the growth of endometriotic lesions in mice and depletes the gut microbiome's beneficial bacterium, Akkermansia muciniphila, which may exacerbate endometriosis symptoms.

12 Nov 2024

Study shows community health workers can improve asthma care for children

While great strides have been made to ensure children have access to proper asthma care in their home and community, linking those environments to the care that children receive while in school has been a challenge.

12 Nov 2024

Air pollution found to contribute to head and neck cancer incidence

A recent study published in the journal Scientific Reports correlates higher levels of pollutant particulate matter to higher occurrences of head and neck aerodigestive cancer.

12 Nov 2024

Machine learning helps predict stroke risk after CF-LVAD implantation

Some patients with advanced heart failure can benefit from the support of a continuous-flow left ventricular assist device (CF-LVAD) to sustain heart function. However, despite improvements managing complications associated with the use of CF-LVADs, stroke continues to be a major adverse event after the implantation of the device.

12 Nov 2024

New treatment offers hope for children with Acute Flaccid Myelitis

Researchers at Kennedy Krieger Institute's International Center for Spinal Cord Injury (ICSCI) have made a remarkable advancement in treating children with Acute Flaccid Myelitis (AFM), a rare but severe neurological condition that causes sudden paralysis.

12 Nov 2024

Everyday physical activity provides immediate benefits for brain health

Exercise has been shown to improve brain health and reduce the risk of cognitive decline and dementia over the long-term.

12 Nov 2024

Novel compound BHB-Phe could offer new approach to weight loss

Researchers at Baylor College of Medicine, Stanford University School of Medicine and collaborating institutions report in the journal Cell the discovery of BHB-Phe, a novel compound produced by the body that regulates appetite and body weight through interactions with neurons in the brain.

12 Nov 2024

New treatment combination improves outcomes for small cell bladder and prostate cancer patients

A research team led by UCLA Health Jonsson Comprehensive Cancer Center investigators has shown that that combining pembrolizumab, an immunotherapy drug, with standard chemotherapy can improve treatment outcomes for patients with small cell bladder cancer and small cell/neuroendocrine prostate cancer.

12 Nov 2024

Vitamin D supplementation may decrease blood pressure in obese older adults

Vitamin D supplements may lower blood pressure in older people with obesity and taking more than the Institutes of Medicine's (IOM) recommended daily dose does not provide additional health benefits, according to new research published in the Journal of the Endocrine Society.

12 Nov 2024

New study highlights the importance of BMI in disease pathogenesis

New study from deCODE genetics/Amgen highlights the importance of BMI in pathogenesis of disease, suggesting that reducing BMI alone could lower the risk of several diseases.

12 Nov 2024

Neuropeptides influence T cell differentiation during viral infections

T helper (TH) cells are essential immune cells that help other immune cells function effectively. When activated in response to environmental stimuli, these cells can differentiate into either TH1 cells, which fight against viruses and intracellular pathogens, or TH2 cells, which fight against extracellular pathogens like bacteria and parasites.

12 Nov 2024

Imbalances in NET homeostasis linked to portal vein thrombosis in CHB-related decompensated cirrhosis

Portal vein thrombosis (PVT) is a challenging complication in liver cirrhosis, with no currently available sensitive diagnostic markers.

12 Nov 2024

TYK2 inhibition may offer new strategy to reduce tau toxicity in Alzheimer's

Researchers at Baylor College of Medicine, the Jan and Dan Duncan Neurological Research Institute (Duncan NRI) at Texas Children's Hospital and collaborating institutions discovered that the enzyme TYK2 transforms the normal protein tau into one that accumulates in the brain and contributes to the development of Alzheimer's disease in animal models.

12 Nov 2024

Wellbeing in the USA shows significant disparities, driven by race, sex, age, and location

A study reveals significant disparities in wellbeing across the U.S., influenced by race, ethnicity, and geography, affecting education, income, and lifespan.

12 Nov 2024

Key reason why some cancers do not respond to immunotherapy identified

Research reveals SLC13A3's role in tumor cell survival and immune therapy resistance, highlighting its potential as a target for improved cancer treatments.

12 Nov 2024

New calculator predicts epilepsy risk after venous stroke

A practical calculator that predicts the risk of epilepsy after venous stroke is presented in a study from the University of Gothenburg and others. The aim is to improve care for those affected, which are predominantly young adults.

12 Nov 2024

Switching from smoking to vaping improves respiratory health

A new paper in Nicotine and Tobacco Research, published by Oxford University Press, finds that people who switch from smoking cigarettes to vaping see improved respiratory health, but people who begin consuming electronic cigarettes while continuing to smoke regular cigarettes do not report improved respiratory symptoms.

12 Nov 2024

Extra hour of weekly exercise reduces risk of atrial fibrillation

Adding an extra hour every week of physical activity may lower the chance of developing the most common type of irregular heartbeat (arrythmia) by 11 percent, a new study shows.

12 Nov 2024