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$Ibrutinib shows added benefit for refractory mantle cell lymphoma patients$

Ibrutinib shows added benefit for refractory mantle cell lymphoma patients

Ibrutinib is a drug for the treatment of rare diseases. It has been approved for the treatment of adults with chronic lymphocytic leukaemia (CLL) or with relapsed or refractory mantle cell lymphoma (MCL) since 2014, and since 2015 also for the treatment of adults with Waldenström macroglobulinaemia. Regarding the treatment of patients with CLL or MCL, the Federal Joint Committee (G-BA) already conducted a benefit assessment and made a decision in 2015.

3 May 2016

Mepolizumab has no hint of added benefit in eosinophilic asthma

The monoclonal antibody mepolizumab has been approved since the end of 2015 for the treatment of adults with severe refractory eosinophilic asthma. The German Institute for Quality and Efficiency in Health Care now examined in an early benefit assessment whether the drug offers an added benefit for patients in comparison with the appropriate comparator therapy.

3 May 2016

Bioengineers develop synthetic bed to nurture colonies of human embryonic stem cells

The most productive way scientists have devised to nurture colonies of human embryonic stem cells is to do so atop a bed of mouse cells. That may be fine for lab research, but it poses an unacceptable contamination risk for stem cells intended for transplant into human patients. In a new study, Brown University bioengineers have developed a synthetic bed that works about as well as the mouse cells, called fibroblasts, without any possibility of contamination.

3 May 2016

Study confirms under-utilization of medication in patients after bypass surgery

Researchers at Thomas Jefferson University discovered that nearly half of coronary artery bypass patients are not taking statins and aspirin together when they are referred for diagnostic cardiac catheterization at least three years after their initial bypass. Their results are currently in press online in the American Journal of Cardiology.

3 May 2016

New nanoparticle approach can deliver antiobesity drugs directly to fat tissue

Researchers at MIT and Brigham and Women's Hospital have developed nanoparticles that can deliver antiobesity drugs directly to fat tissue. Overweight mice treated with these nanoparticles lost 10 percent of their body weight over 25 days, without showing any negative side effects.

3 May 2016

Researchers develop SpiroCall that can accurately measure lung function over simple phone call

Most people in the developing world who have asthma, cystic fibrosis or other chronic lung diseases have no way to measure how well their lungs are functioning outside of a clinic or doctor visit.

3 May 2016

Scientists discover genetic switches linked to increased lifespan in mammals

Newly discovered genetic switches that increase lifespan and boost fitness in worms are also linked to increased lifespan in mammals, offering hope that drugs to flip these switches could improve human metabolic function and increase longevity.

3 May 2016

Snapshots of NMDA receptor activation may help in novel drug design

Structural biologists at Cold Spring Harbor Laboratory and Janelia Research Campus/HHMI, have obtained snapshots of the activation of an important type of brain-cell receptor. Dysfunction of the receptor has been implicated in a range of neurological illnesses, including Alzheimer's disease, Parkinson's disease, depression, seizure, schizophrenia, autism, and injuries related to stroke.

3 May 2016

FDA’s new education campaign for LGBT young adults aims to prevent, reduce tobacco use

The U.S. Food and Drug Administration today announced the launch of a historic public education campaign aimed at preventing and reducing tobacco use among lesbian, gay, bisexual and transgender (LGBT) young adults ages 18-24. Of the more than 2 million LGBT young adults in the U.S., more than 800,000 smoke occasionally. The "This Free Life" campaign is designed to specifically reach the occasional or "social" smokers in the LGBT community to help prevent tobacco-related disease and the loss of tens of thousands LGBT lives to tobacco use each year.

3 May 2016

MII-pH can help doctors confirm diagnosis of GERD in newborns before treatment

Millions of Americans currently use medication for their indigestion and reflux, so it may come as no surprise that parents and doctors also prescribe medicine for newborns with reflux. However, according to a new study, newborns are likely being over treated the majority of the time with interventions - including surgery - that have risks for the infant.

3 May 2016

Fish oil supplements combined with anti-cancer therapy can reduce renal cell carcinoma

Researchers at UC Davis have shown that docosahexaenoic acid (DHA), a fatty acid commonly found in fish and fish oil supplements, reduces renal cell carcinoma invasiveness, growth rate, and blood vessel growth when combined with the anti-cancer therapy regorafenib. The study was published in the journal Molecular Cancer Therapeutics.

3 May 2016

UGA researcher works to advance effective treatment for infectious mononucleosis

The University of Georgia's Mark Ebell wasn't impressed with research on infectious mononucleosis when he wrote his first published review on it back in the 1990s. He still isn't—a subject he discusses in the April issue of the Journal of the American Medical Association.

3 May 2016

Key method to test compounds for anti-cancer activity in cells flawed, study reveals

The primary method used to test compounds for anti-cancer activity in cells is flawed, Vanderbilt University researchers report May 2 in Nature Methods. The findings cast doubt on methods used by the entire scientific enterprise and pharmaceutical industry to discover new cancer drugs.

3 May 2016

Social networks may cause stress to children and adolescents

Research has shown the significance of social relationships in influencing adult human behavior and health; however, little is known about how children's perception of their social networks correlates with stress and how it may influence development. Now, a University of Missouri research team has determined that children and adolescents physically react to their social networks and the stress those networks may cause. Scientists believe that the quality and size of the social relationships nurtured in childhood may have important physiological consequences for physical and mental health for youth.

3 May 2016

Antibiotic treatment may allow bad bugs to flourish

Antibiotics are essential for fighting bacterial infection, but, paradoxically, they can also make the body more prone to infection and diarrhea.

3 May 2016

NEI-funded study analyzes outcomes of anti-VEGF therapy for AMD

In a study of nearly 650 people with the eye disease age-related macular degeneration (AMD), half still had vision 20/40 or better, typically good enough to drive or to read standard print, after five years of treatment with anti-VEGF drugs that are injected into the eye. The authors of the study, funded by the National Eye Institute (NEI) at the National Institutes of Health, say those outcomes would have been unimaginable about 10 years ago, prior to the drugs' availability.

3 May 2016

New method may help identify small amounts of nanomaterials in environment samples

It is still unclear what the impact is on humans, animals and plants of synthetic nanomaterials released into the environment or used in products. It's very difficult to detect these nanomaterials in the environment since the concentrations are so low and the particles so small. Now the partners in the NanoUmwelt project have developed a method that is capable of identifying even minute amounts of nanomaterials in environmental samples.

2 May 2016

NEI to discuss research advances in regenerative medicine for eye disease at ARVO 2016

The National Eye Institute (NEI), part of NIH, is participating in the Inaugural Press Conference from the Association for Research in Vision and Ophthalmology Annual Meeting (ARVO 2016), the largest gathering of eye and vision researchers in the world, attracting over 11,000 attendees from more than 75 countries.

2 May 2016

Study on Zika exposure among HIV-infected patients in Ghana

What many may not know is that the Zika virus is a distant cousin of hepatitis C, a blood borne-virus that attacks the liver and often co-infects HIV patients.

2 May 2016

Half-strength apple juice followed by preferred fluid choice better for treating kids with mild gastroenteritis

Children with mild gastroenteritis and minimal dehydration experienced fewer treatment failures such as IV rehydration or hospitalization when offered half-strength apple juice followed by their preferred fluid choice compared with children who received electrolyte maintenance solution to replace fluid losses, according to a study published online by JAMA. The study is being released to coincide with its presentation at the Pediatric Academic Societies meeting.

2 May 2016

Medical Research News

Ibrutinib shows added benefit for refractory mantle cell lymphoma patients

Mepolizumab has no hint of added benefit in eosinophilic asthma

Bioengineers develop synthetic bed to nurture colonies of human embryonic stem cells

Study confirms under-utilization of medication in patients after bypass surgery

New nanoparticle approach can deliver antiobesity drugs directly to fat tissue

Researchers develop SpiroCall that can accurately measure lung function over simple phone call

Scientists discover genetic switches linked to increased lifespan in mammals

Snapshots of NMDA receptor activation may help in novel drug design

FDA’s new education campaign for LGBT young adults aims to prevent, reduce tobacco use

MII-pH can help doctors confirm diagnosis of GERD in newborns before treatment

Fish oil supplements combined with anti-cancer therapy can reduce renal cell carcinoma

UGA researcher works to advance effective treatment for infectious mononucleosis

Key method to test compounds for anti-cancer activity in cells flawed, study reveals

Social networks may cause stress to children and adolescents

Antibiotic treatment may allow bad bugs to flourish

NEI-funded study analyzes outcomes of anti-VEGF therapy for AMD

New method may help identify small amounts of nanomaterials in environment samples

NEI to discuss research advances in regenerative medicine for eye disease at ARVO 2016

Study on Zika exposure among HIV-infected patients in Ghana

Half-strength apple juice followed by preferred fluid choice better for treating kids with mild gastroenteritis

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