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Cigarette smoking, viral infections may reduce effectiveness of COPD symptom-reliever medication

New study backs up observations in Chronic Obstructive Pulmonary Disease (COPD) patients showing reduced effectiveness of symptom-reliever medication (β2-adrenoceptor agonists) in flare-ups linked to cigarette smoking and infection with viruses such as influenza.

11 Apr 2016

Novel nanoparticle drug delivery system for enhanced tumor penetration of cancer drugs

For more than a decade, biomedical researchers have been looking for better ways to deliver cancer-killing medication directly to tumors in the body. Tiny capsules, called nanoparticles, are now being used to transport chemotherapy medicine through the bloodstream, to the doorstep of cancerous tumors.

11 Apr 2016

Cyclodextrin dissolves cholesterol crystals, reduces atherosclerotic plaques

Cardiovascular disease from atherosclerosis is one of the most common causes of death worldwide. Inflammation plays a crucial role in atherosclerosis and cholesterol crystals are considered to be early triggers in the development of the disease.

11 Apr 2016

Study reveals new activation mechanism for protein kinases

Protein kinases, most scientists would agree, regulate nearly every aspect of cell life. It is no surprise, then, that having faulty protein kinases may lead to a number of human conditions, including cardiovascular diseases, cancer and diabetes.

11 Apr 2016

Researchers identify influenza D antibodies in small ruminants

Although a new influenza virus, now called influenza D, was discovered first in pigs, researchers found it was more common in cattle. However, further research has identified antibodies to the virus in small ruminants, but not in poultry.

11 Apr 2016

Study finds how tumour cells grow through scavenging bad cholesterol

Several studies have recognized a link between obesity and cancer. Richard Lehner, professor of Pediatrics and investigator at the University of Alberta's Faculty of Medicine & Dentistry, has taken his research further to understand how tumour cells grow through scavenging very low-density lipoproteins (VLDL) and low-density lipoproteins (LDL), commonly known as the "bad cholesterol", and what mechanisms can be used to reduce the malignant cells' growth.

11 Apr 2016

Added benefit of crizotinib drug for first-line treatment of advanced bronchial carcinoma not proven

The drug crizotinib (trade name: Xalkori) has been available since 2012 for patients with advanced non-small cell lung cancer (bronchial carcinoma) who have a high activity of the enzyme anaplastic lymphoma kinase (ALK) and have already received another treatment. In November 2015, the approval was extended to first-line treatment.

11 Apr 2016

Long-term medication use reduces risk of relapse and improves symptoms in BDD patients

People with Body Dysmorphic Disorder (BDD) fare better and are less likely to relapse when treated with medication on a long-term basis, according to researchers at Rhode Island Hospital and Massachusetts General Hospital.

11 Apr 2016

Researchers identify gene crucial to development of coeliac disease

Coeliac disease is a chronic, immunological disease that is manifested as intolerance to gluten proteins present in wheat, rye and barley. This intolerance leads to an inflammatory reaction in the small intestine that hampers the absorption of nutrients. The only treatment is a strict, life-long, gluten-free diet.

11 Apr 2016

Simple blood test rapidly detects key genetic mutations in non-small cell lung tumors

A simple blood test can rapidly and accurately detect mutations in two key genes in non-small cell lung tumors, researchers at Dana-Farber Cancer Institute and other institutions report in a new study - demonstrating the test's potential as a clinical tool for identifying patients who can benefit from drugs targeting those mutations.

11 Apr 2016

Rockefeller scientists study molecular mechanism that causes linker cell death in worms

Some cells are meant to live, and some are meant to die. The linker cell of Caenorhabditis elegans, a tiny worm that is a favored model organism for biologists, is among those destined for termination.

11 Apr 2016

Rituximab shows second-line promise in autoimmune limbic encephalitis

Rituximab is an effective and well-tolerated second-line treatment for patients with autoimmune limbic encephalitis, suggests research.

7 Apr 2016

Epilepsy drug exposure does not increase newborn orofacial cleft risk

Pregnant women with epilepsy should not rule out continuing lamotrigine therapy due to concerns that exposure could increase the risk of orofacial clefts in their babies, say investigators.

7 Apr 2016

Researchers identify severe side effects of Clozapine drug

Clozapine (CLZ) is a "gold standard" drug for managing treatment-resistant schizophrenia (TRS), who do not respond adequately to first-line antipsychotics.

7 Apr 2016

Parent, provider partnership benefits child's development during transition from home to non-parental care

A new University of Illinois study reveals that the transition from home to child care is an important time for creating a partnership between parent and provider that benefits the child's development.

7 Apr 2016

Vanderbilt's A.S.A.P sees increase in number of patients treated for alpha-gal syndrome

Vanderbilt's Asthma, Sinus and Allergy Program (A.S.A.P) has seen an increase in the number of patients being treated for alpha-gal syndrome, commonly known as the red meat allergy linked to tick bites.

7 Apr 2016

Genetically modified pig hearts can survive for more than 2 years after transplantation into baboons

Could organs explanted from other mammals save human lives someday? A new study shows that genetically modified pig hearts developed by US and Ludwig-Maximilians-Universitaet in Munich researchers can survive for more than up to 2½ years when transplanted into baboons.

7 Apr 2016

Shortened RT schedule has similar efficacy as conventional RT schedule in low-risk prostate cancer patients

Of the more than 220,000 patients newly diagnosed with prostate cancer in 2015, the vast majority will have had early-stage disease at low risk for recurrence.

7 Apr 2016

Older American men pay for more sex as they age, study finds

Older American male customers of sex workers pay for more sex as they age. These findings are reported in a study which surveyed older American men who frequent sex work websites and discussion boards. It was conducted by Los Angeles-based psychotherapist Christine Milrod and sociologist Martin Monto of the University of Portland in the US and published in Springer's journal Archives of Sexual Behavior.

7 Apr 2016

Entresto drug shows added benefit in symptomatic chronic heart failure

The fixed-dose combination of sacubitril and valsartan (trade name: Entresto) has been approved since November 2015 for adults with symptomatic chronic heart failure with reduced pump function (ejection fraction). The German Institute for Quality and Efficiency in Health Care (IQWiG) now examined in an early benefit assessment whether this drug combination offers an added benefit for patients in comparison with the appropriate comparator therapy.

7 Apr 2016

Medical Research News

Cigarette smoking, viral infections may reduce effectiveness of COPD symptom-reliever medication

Novel nanoparticle drug delivery system for enhanced tumor penetration of cancer drugs

Cyclodextrin dissolves cholesterol crystals, reduces atherosclerotic plaques

Study reveals new activation mechanism for protein kinases

Researchers identify influenza D antibodies in small ruminants

Study finds how tumour cells grow through scavenging bad cholesterol

Added benefit of crizotinib drug for first-line treatment of advanced bronchial carcinoma not proven

Long-term medication use reduces risk of relapse and improves symptoms in BDD patients

Researchers identify gene crucial to development of coeliac disease

Simple blood test rapidly detects key genetic mutations in non-small cell lung tumors

Rockefeller scientists study molecular mechanism that causes linker cell death in worms

Rituximab shows second-line promise in autoimmune limbic encephalitis

Epilepsy drug exposure does not increase newborn orofacial cleft risk

Researchers identify severe side effects of Clozapine drug

Parent, provider partnership benefits child's development during transition from home to non-parental care

Vanderbilt's A.S.A.P sees increase in number of patients treated for alpha-gal syndrome

Genetically modified pig hearts can survive for more than 2 years after transplantation into baboons

Shortened RT schedule has similar efficacy as conventional RT schedule in low-risk prostate cancer patients

Older American men pay for more sex as they age, study finds

Entresto drug shows added benefit in symptomatic chronic heart failure

Synthetic Biology and the Pursuit of Living Diagnostics

Modular, Scalable, Intelligent: How n6 Is Rethinking NGS Library Prep

Evolving spectrophotometry for modern biopharma workflows

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