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Discovery of a new kind of messenger RNA molecule

Researchers at Cold Spring Harbor Laboratory have discovered a new kind of messenger RNA molecule that is converted from non-protein coding status to protein coding status in response to cellular stress such as viral infection.

20 Oct 2005

Spliceosome crucial for processing non-coding RNA

The discovery in 1977 that the coding regions of a gene could appear in separate segments along the DNA won the 1993 Nobel Prize in Physiology or Medicine for Richard J. Roberts and Phillip A. Sharp. The active segments of a gene were termed exons, separated from each other within the gene by inactive introns.

20 Oct 2005

Molecule P-glycoprotein (Pgp), may help reduce risk of Alzheimer's

A molecule that has long been an obstacle to cancer chemotherapy and drug treatments for brain disorders may soon become an ally in the fight against Alzheimer's disease, according to researchers at Washington University School of Medicine in St. Louis and the University of Rochester.

20 Oct 2005

Alzheimer disease and the blood brain barrier

Increased production of the amyloid-beta (Abeta) peptide can lead to Abeta aggregation and buildup in the brain and rare familial forms of early onset Alzheimer disease (AD).

20 Oct 2005

Identification of a factor in human milk that can block HIV-1 transmission

Mother to child transmission of HIV accounts for a large proportion of HIV infections in children, with many infected as a result of breastfeeding, which requires transfer of the virus across mucosal barriers. DC-SIGN, a DC lectin receptor, interacts with HIV and is found at high expression levels in tonsillar tissue.

20 Oct 2005

Retiring early is not linked to longer life

There is a widespread perception that early retirement is associated with longer life expectancy and later retirement is associated with early death. But no consensus has been reached on the effect of early retirement on survival.

20 Oct 2005

U.S. health inequalities cause 84,000 extra deaths every year

Research estimates that health inequalities between white and black Americans cause 84,000 extra deaths every year – equating to a virtual hurricane Katrina every week, says an editorial in this week’s British Medical Journal.

20 Oct 2005

26% of HIV-infected individuals reported that they felt discriminated against by physicians

Research published in the Journal of General Internal Medicine reveals that 26% of HIV-infected individuals reported that they felt discriminated against by physicians and other health care providers. Despite demographic variations, all subgroups reported discrimination of some type.

20 Oct 2005

Screening test would give hope to childless couples

According to new research thousands of childless British couples could greatly improve their chances of having a baby if a test that weeds out faulty embryos were carried out.

20 Oct 2005

Research reveals possible mechanisms for the treatment of cocaine addiction

Researchers are now understanding in greater detail the molecular machinery underlying the short-term brain changes that produce the high of cocaine, as well as the longer-term changes behind addiction. Their findings offer hope for targeted drugs that can short-circuit that addiction machinery.

19 Oct 2005

Identification of a single chromosome region linked to specific language impairment

Researchers at the University of Toronto (U of T), Capital Health's Stollery Children's Hospital in Edmonton, Toronto's Hospital for Sick Children and their international collaborators have discovered a genetic abnormality that causes a type of language impairment in children

19 Oct 2005

A DNA-based vaccine could be a potent weapon against bird flu

Researchers scrambling to combat a virulent form of bird flu that could mutate into a form easily spread among humans should consider developing vaccines based on DNA, according to British biochemical engineers.

19 Oct 2005

South Korea opens controversial international stem cell bank

South Korea has opened a bank in Seoul that will create and supply new lines of embryonic stem cells for research around the world.

19 Oct 2005

Fertility treatment most successful in summer

When it comes to considering fertility treatment, scientists say that women who have the treatment during the summer are twice as likely to become pregnant as those who have it in the winter.

19 Oct 2005

Surgery to treat obesity far more risky for men

Researchers say that using stomach-shrinking surgery to treat severe obesity is riskier than previously thought for men, the elderly and people with conditions such as hypertension.

19 Oct 2005

Yeast cells help show how GSAO (glutathionarsenoxide) angiogenesis inhibitor drug works

The humble yeast has revealed the molecular workings of an anti-cancer drug that stops the growth and spread of tumours in humans by starving their blood supply.

18 Oct 2005

People who carry a mutation in the melanoma susceptibility gene CDKN2A have a much lower risk of melanoma

In addition, most familial clusters of melanoma occur in families without identifiable mutations in this gene, according to a new study that appears in the October 19 issue of the Journal of the National Cancer Institute.

18 Oct 2005

Aβ and Fyn cooperate to cause Alzheimer-like changes in the brain

Reporting in two companion papers in the October 19 issue of the Journal of Neuroscience, investigators from the Gladstone Institute of Neurological Disease show in genetically engineered mouse models of the disease that the accumulation of Alzheimer-related neurotoxic amyloid-beta (Aâ) peptides can deplete key proteins in a specific memory center of the brain.

18 Oct 2005

Newly discovered role of MECP2 gene in Rett Syndrome

Huda Zoghbi, of Baylor College of Medicine and the Howard Hughes Medical Institute and Juan Young, also of Baylor and colleagues report in the online Early Edition of the Proceedings of the National Academy of Science, posted the week of October 17, 2005, that the Rett Syndrome gene, MECP2, regulates RNA splicing.

18 Oct 2005

Atypical antipsychotic drugs slightly increase risk for death when used in people with dementia

Atypical antipsychotic drugs seem to confer a small increased risk for death when used in people with dementia, concludes a team of researchers from the Keck School of Medicine of the University of Southern California in a meta-analysis of 15 clinical trials published in the October 19 issue of the JAMA: The Journal of the American Medical Association.

18 Oct 2005