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Key RNA pathway controlling DNA packaging and cancer progression

Inside every cell, inside every nucleus, your continued existence depends on an incredibly complicated dance. Proteins are constantly wrapping and unwrapping DNA, and even minor missteps can lead to cancer.

3 Oct 2024

The impact of KRAS mutations on pancreatic cancer progression and survival

A common mutation in the KRAS gene is associated with improved overall survival in pancreatic ductal adenocarcinoma (PDAC) compared with other variants, in part because the mutation appears to lead to less invasiveness and weaker biological activity, according to a multicenter study conducted at Weill Cornell Medicine, NewYork-Presbyterian, Memorial Sloan Kettering Cancer Center, and other institutions.

3 Oct 2024

Fruit fly brain connectome offers critical clues for understanding brain function and behavior

A scientific team supported by the National Institutes of Health (NIH) unveiled the first complete map of the neural connections of the common fruit fly brain. The map provides a wiring diagram, known as a connectome, and is the largest and most complete connectome of an adult animal ever created.

3 Oct 2024

Revvity's EUROIMMUN launches solution for specific typing of Alzheimer's disease associated APOE gene

Revvity, Inc., announced today the launch of the in-vitro diagnostic EURORealTime™ APOE assay in European countries that accept the CE mark, which will enable accurate genotyping of the APOE gene. APOE genotyping is valuable to assess a patient’s risk for side effects prior to the start of an anti-amyloid (beta) therapy for Alzheimer’s disease.

3 Oct 2024

Implantable device revolutionizes thyroid management

A Carnegie Mellon University-led team has secured an award of up to $42 million from the Advanced Research Projects Agency for Health (ARPA-H) to accelerate the development of implantable, cell-based bioelectronic devices that deliver patient-specific therapy and monitor disease status, for conditions like hypo- and hyperthyroidism, in real time.

3 Oct 2024

SWOG S1011 trial questions the benefits of extended lymphadenectomy in bladder cancer

The SWOG S1011 randomized phase 3 trial found no significant improvement in disease-free or overall survival but a higher rate of grade 3-4 adverse events and an increased risk of death in the 90 days after surgery.

3 Oct 2024

Scientists overcome major challenge in gene therapy and drug delivery

Imagine trying to poke a hole in the yolk of a raw egg without breaking the egg white. It sounds impossible, but researchers at the University of California San Diego have developed a technology that performs a similarly delicate task in living cells. They created an array of nanopillars that can breach the nucleus of a cell - the compartment that houses our DNA - without damaging the cell's outer membrane.

3 Oct 2024

Mediterranean diet significantly lowers heart failure risk, especially in women

Increased adherence to the Mediterranean diet significantly lowers the risk of heart failure, especially in women, according to a recent European meta-analysis. The diet's anti-inflammatory and antioxidant properties are key to its protective effects.

3 Oct 2024

Circadian rhythm influences dementia diagnosis and disease progression

The time of day when blood is taken can affect the results of tests for diagnosing dementia, according to new research led by the University of Surrey.

3 Oct 2024

Study reveals sharp increase in vaping among never-regular smokers in England

The number of adults vaping in England who have never regularly smoked has increased sharply since 2021, when disposable e-cigarettes first became popular, according to a new study by UCL researchers.

3 Oct 2024

Accelerating tobacco decline could boost global life expectancy

Accelerating the decline in tobacco smoking globally, by decreasing smoking prevalence from current levels to 5% everywhere, could increase life expectancy and prevent millions of premature deaths by 2050, according to a study from the Global Burden of Disease, Injuries and Risk Factors (GBD) Tobacco Forecasting Collaborators published in The Lancet Public Health journal.

3 Oct 2024

Ketogenic diet lowers mortality by 24% while maintaining heart health

Study confirms that adherence to a ketogenic diet reduces all-cause mortality risk by 24% without increasing cardiovascular mortality in a large US cohort. Findings support KD as a beneficial intervention for long-term health.

3 Oct 2024

Creating a tobacco-free generation could prevent 1.2 million lung cancer deaths

Creating a generation of people who never smoke could prevent 1.2 million deaths from lung cancer globally, according to a study led by researchers from the University of Santiago de Compostela, the International Agency for Research on Cancer (IARC), and global collaborators published in The Lancet Public Health journal.

3 Oct 2024

UCLA develops CORE score to assess surgical mortality risk

A UCLA research team has created the Comorbid Operative Risk Evaluation (CORE) score to better account for the role chronic illness plays in patient's risk of mortality after operation, allowing surgeons to adjust to patients' pre-existing conditions and more easily determine mortality risk.

3 Oct 2024

Primary care settings failing to address women's hot flashes

Timely identification and treatment of bothersome hot flashes have the potential to improve the lives of many women and save employers countless days of related absenteeism and lost work productivity. Yet, a new study finds that such symptoms are often not documented in electronic health records (EHRs) or not adequately addressed during primary care visits.

3 Oct 2024