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Cancer-related nerve injury triggers inflammation and immunotherapy resistance

Cancer cells can break down the protective covers around nerves, causing nerve injury that triggers chronic inflammation leading to immune exhaustion and eventual resistance to immunotherapy, according to new research from The University of Texas MD Anderson Cancer Center.

1 Sep 2025

Genomic clues uncover early origins of multiple myeloma

A new study maps out the timeline of DNA damage for multiple myeloma, the second most common blood cancer.

1 Sep 2025

Gait retraining reduces pain and slows knee damage in osteoarthritis

Nearly a quarter of people over the age of 40 experience painful osteoarthritis, making it a leading cause of disability in adults.

1 Sep 2025

Study provides evidence for a causal genetic link between prostate cancer and urothelial carcinoma

Prostate cancer is among the most common cancers in men and a leading cause of cancer-related deaths. With improved detection and therapies, survival rates have risen, but this progress comes with a new concern: the risk of secondary primary malignancies.

1 Sep 2025

$New hypothesis links internal fat biology to heart failure with preserved ejection fraction$

New hypothesis links internal fat biology to heart failure with preserved ejection fraction

Heart failure with preserved ejection fraction (HFpEF) appears to develop as a result of changes in the biology of a person's internal fat tissue, according to the Adipokine Hypothesis, a new way of understanding how fat may impact the heart.

1 Sep 2025

Drug-coated devices not associated with improved outcomes in patients with peripheral artery disease

Drug-coated stents and balloons were not associated with reduced risk of amputation or improved quality of life compared with uncoated devices in two trials in peripheral artery disease (PAD), according to late-breaking research presented in a Hot Line session today at ESC Congress 2025.

1 Sep 2025

Tailored risk-based treatment does not improve outcomes in atrial fibrillation

An individually tailored multidimensional risk-based treatment strategy was not associated with improvements in clinical outcomes compared with usual guideline-based care in patients with atrial fibrillation (AF), according to late-breaking research presented in a Hot Line session today at ESC Congress 2025.

1 Sep 2025

Research finds no added benefit from routine CT imaging after left main coronary intervention

Routine coronary computed tomography (CCT)-based follow-up after percutaneous coronary intervention (PCI) of the left main coronary artery did not reduce death, myocardial infarction (MI), unstable angina or stent thrombosis compared with symptom-based follow-up, according to late-breaking research presented in a Hot Line session today at ESC Congress 2025.

1 Sep 2025

ICD treatment does not lower death risk in patients with abnormal ECG after myocardial infarction

Prophylactic implantable cardioverter defibrillator therapy did not reduce mortality in patients with a prior myocardial infarction, persistent moderate left ventricular systolic dysfunction and abnormal ECG markers, according to late-breaking research presented in a Hot Line session today at ESC Congress 2025.

1 Sep 2025

AMALFI trial finds small increase in AF diagnosis with mail-based ECG patch monitoring

A mail-based atrial fibrillation (AF) screening programme with ECG-patch monitoring led to a modest long-term increase in AF diagnosis and anticoagulation exposure in older patients at moderate-to-high stroke risk, according to a late-breaking trial presented in a Hot Line session today at ESC Congress 2025 and simultaneously published in JAMA (The Journal of the American Medical Association).

1 Sep 2025

Diabetes drug metformin alters blood metal levels in humans

The widely used diabetes drug metformin changes blood metal levels in humans. The Kobe University study is an important step in understanding the drug's many actions and designing better ones in the future.

1 Sep 2025

Scientists discover molecular brake that limits T cell attack on tumors

In a discovery that could expand the array of current cancer immunotherapy treatments, scientists at Harvard Medical School have identified a new molecular brake that hinders the ability of T cells to attack tumors.

1 Sep 2025

Better education and income reduce anxiety about growing old

Investigating aging anxiety in China, this research links socioeconomic status to mental health, showing how education and income can alleviate fears of aging.

1 Sep 2025

Can oral bacteria make heart disease worse?

The presence of viridans streptococci in coronary plaques indicates a role in atherosclerosis, potentially influencing heart disease outcomes.

1 Sep 2025

Babies fed blueberries show fewer allergy symptoms and boosted immune balance

Daily blueberry powder given to infants during complementary feeding modestly influenced allergic symptom resolution and shaped immune biomarker–microbiota associations. Findings suggest early diet may play a role in immune development, though results are preliminary and exploratory.

31 Aug 2025

How plant compounds could target Alzheimer’s disease from multiple angles

This review highlights how dietary polyphenols modulate Alzheimer’s disease biology through antioxidant, anti-inflammatory, and multi-target mechanisms, supported by in-silico docking analyses. Despite promise, challenges in bioavailability and brain delivery remain key hurdles to clinical translation.

31 Aug 2025

Ultra-processed foods affect sperm quality and metabolism even without extra calories

A controlled crossover trial in Cell Metabolism found that ultra-processed foods increase weight, fat mass, LDL:HDL cholesterol, and alter reproductive hormones in men, with some effects independent of calorie load. These diets also showed trends toward reduced sperm motility, shifts in pollutants, and transient inflammatory responses, highlighting risks beyond excess calories.

31 Aug 2025

Discovery of mitochondrial microprotein opens path to obesity and aging therapies

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Medical Research News

Cancer-related nerve injury triggers inflammation and immunotherapy resistance

Genomic clues uncover early origins of multiple myeloma

Gait retraining reduces pain and slows knee damage in osteoarthritis

Study provides evidence for a causal genetic link between prostate cancer and urothelial carcinoma

New hypothesis links internal fat biology to heart failure with preserved ejection fraction

Drug-coated devices not associated with improved outcomes in patients with peripheral artery disease

Tailored risk-based treatment does not improve outcomes in atrial fibrillation

Research finds no added benefit from routine CT imaging after left main coronary intervention

ICD treatment does not lower death risk in patients with abnormal ECG after myocardial infarction

AMALFI trial finds small increase in AF diagnosis with mail-based ECG patch monitoring

Diabetes drug metformin alters blood metal levels in humans

Scientists discover molecular brake that limits T cell attack on tumors

Better education and income reduce anxiety about growing old

Can oral bacteria make heart disease worse?

Babies fed blueberries show fewer allergy symptoms and boosted immune balance

How plant compounds could target Alzheimer’s disease from multiple angles

Ultra-processed foods affect sperm quality and metabolism even without extra calories

Discovery of mitochondrial microprotein opens path to obesity and aging therapies

New mouse models reveal mechanisms of RP59 retinal degeneration

Transcription factors SP5 and SP8 regulate primary cilia formation in embryos

AI in Healthcare: How generative tools are transforming clinical practice

The future of automation: Machine learning–driven hepatocyte and organoid counting

From street to lab: Advancing controlled substance testing with handheld Raman and FTIR

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