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RecA protein skips "unwinding" step in DNA repair

Researchers from Tokyo Metropolitan University have been studying DNA repair by homologous recombination, where the RecA protein repairs breaks in double-stranded DNA by incorporating a dangling single-strand end into intact double strands, and repairing the break based on the undamaged sequence.

20 Jan 2024

COVID-19-associated blood plasma inflammatory factors do not affect blood-brain barrier, study shows

It is now well documented that the coronavirus outbreak triggered a global health crisis. In this study, researchers wanted to know whether blood-brain barrier impairment contributed to the development of neurological problems during COVID-19 progression, and to what extent.

19 Jan 2024

Immune checkpoint inhibitor target found to promote skin cancer growth

Programmed cell death 1 (PD-1) is an important target for immune checkpoint inhibitor therapies that block its signaling and boost T-cell activity. PD-1 inhibitors have been approved for treating various types of cancer.

19 Jan 2024

Study reveals disparities in emergency department restraint use by race and ethnicity

A new study that contributes additional data to a growing body of evidence demonstrating disparities in restraint use in the emergency department (ED) has been published in the January issue of Academic Emergency Medicine (AEM), the peer-reviewed journal of the Society for Academic Emergency Medicine (SAEM).

19 Jan 2024

Ludwig scientists deconstruct the blood supply of brain metastases

A Ludwig Cancer Research study has generated a granular portrait of how the cellular and molecular components of the blood vessels that feed brain metastases of melanoma and lung and breast cancers differ from those of healthy brain tissue, illuminating how they help shape the internal environment of tumors to support cancer growth and immune evasion.

19 Jan 2024

Memory T cells learn and adapt: Post-Omicron immunity offers wider protection

It has been 4 years since the start of the COVID-19 pandemic. SARS-CoV-2 has yet to be eradicated and new variants are continuously emerging.

19 Jan 2024

Antiviral hope emerges as viruses linked to multiple myeloma

A few years ago, a patient was cured of multiple myeloma after being treated for hepatitis C, astounding researchers from the group led by Joaquín Martínez, from the H12O-CNIO Haematological Tumours Clinical Research Unit, a collaboration between the Hospital 12 de Octubre (H12O) and the National Cancer Research Centre (CNIO).

19 Jan 2024

Tailored opioid prescribing limits more effective at reducing prescription length, study finds

Many states have passed new laws that place restrictions on the duration of first-time opioid prescriptions to help address the opioid epidemic.

19 Jan 2024

£1.9M funding supports research into drivers of health disparities and associated infectious disease burden

Dr Rosalind Eggo, an Associate Professor of Infectious Disease Modelling at the London School of Hygiene & Tropical Medicine (LSHTM), has been awarded over £1.9 million funding to lead research into drivers of health disparities and associated infectious disease burden across England.

19 Jan 2024

Annexin-A1 targeted therapy beats several cancers

A new study published in Nature's cancer journal Oncogene highlights the effectiveness of MDX-124, the first therapeutic drug to target annexin-A1, a protein which is overexpressed in several cancer types and promotes tumour progression.

19 Jan 2024

Women using drugs and alcohol can feel stigmatized when seeking treatment

Women using drugs and alcohol can feel stigmatized and shamed when seeking support from professional services, a new study has found.

19 Jan 2024

New oral insulin delivered via nano-carriers could soon replace injections

There are approximately 425 million people worldwide with diabetes. Approximately 75 million of these inject themselves with insulin daily.

19 Jan 2024

Unveiling the cellular mechanisms of engram consolidation and memory refinement

Think of a time when you had two different but similar experiences in a short period. Maybe you attended two holiday parties in the same week or gave two presentations at work.

19 Jan 2024

Groundbreaking study identifies FAM3C as a key regulator of breast cancer progression

A groundbreaking study conducted by Professor Jiyoung Park and her research team in the Department of Biological Sciences at UNIST has identified FAM3C, a metabolism-regulating signaling molecule produced by cancer-associated adipocytes (CAAs), as a key regulator of breast cancer progression within the tumor microenvironment (TME).

19 Jan 2024

Study analyzes the use of tissue-agnostic therapeutics in patients with primary brain tumors

Researchers from Miami Cancer Institute, part of Baptist Health South Florida, today published a study in Trends in Cancer that analyzes the use of tissue-agnostic therapeutics in patients with primary brain tumors (PBTs).

19 Jan 2024

New discovery sheds light on the genetic basis of a rare skeletal disorder

A McGill-led team of researchers have made an important discovery shedding light on the genetic basis of a rare skeletal disorder.

19 Jan 2024

Racial disparity identified in referral for infantile epileptic spasms syndrome

Infantile epileptic spasms syndrome (IESS), often called infantile spasms, is the most common form of epilepsy seen during infancy.

19 Jan 2024

Bacteria's "suicidal" immune system boosts antibiotic power against cholera

Bacteria have an immune system that protects them against viruses known as bacteriophages. A research team from the Universities of Tübingen and Würzburg has now shown how this immune system enhances the effect of specific antibiotics against the cholera pathogen Vibrio cholerae.

19 Jan 2024

New study challenges role of rectal exam in prostate cancer screening

A study by the Comprehensive Cancer Center Vienna of MedUni Vienna and Vienna General Hospital has taken a closer look at the effectiveness of common examination methods for the early detection of prostate cancer.

19 Jan 2024