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What is the optimal dosing regimen for remdesivir in COVID-19 patients? A computational model

A team of scientists from the Pennsylvania State University, USA, recently analyzed the pharmacodynamics and pharmacokinetics of antiviral drug remdesivir using computational models. Based on the study findings, which are yet to be peer-reviewed, the scientists recommend that for effective inhibition of SARS-CoV-2 infection, remdesivir should be used with other antiviral medicines, or its dosing regimen should be optimized to improve bioavailability.

22 Jun 2021

Researchers screen Chinese herbal medicines and plant compounds for anti-SARS-CoV-2 activity

A review published in Phytotherapy Research discussed the natural anti-SARS-CoV-2 products identified based on in silico prediction. The review’s authors also illustrate the impact of many phytochemicals either alone or in combination with traditional treatments and their potential molecular mechanisms involved in SARS-CoV-2 prevention and treatment.

22 Jun 2021

The effect of novel insertion mutation in SARS-CoV-2 spike glycoprotein RNA

In a recent study, a group of researchers discuss the functional implications of this specific S protein mutation on SARS-CoV-2.

22 Jun 2021

Does SARS-CoV-2 alter the expression of molecules involved in the homeostasis of blood pressure?

A recent study finds that COVID-19 alters the expression of several molecules involved in the homeostasis of blood pressure.

22 Jun 2021

New test bed launched to advance the regenerative medicine field

The RegeneratOR Test Bed has officially launched, bringing together resources to advance the regenerative medicine field nationally and create an economic development engine for the region and the state overall.

22 Jun 2021

New human organoid mimics the earliest developmental steps of the nervous system in embryos

The progression from a round ball of cells to an embryo with a head and a tail is one of the most critical steps in an organism's development. But just how cells first start organizing themselves with directionality along this head-to-tail axis is hard to study because it happens in the earliest days of embryonic development, in the confines of a mammal's uterus.

22 Jun 2021

Researchers decode the mechanisms of cell renewal process

The human intestine is made up of more than 40 square meters of tissue, with a multitude of folds on its internal surface that resemble valleys and mountain peaks in order to increase the absorption of nutrients.

22 Jun 2021

Dual-antibody combination therapies effective against SARS-CoV-2 variants in animal study

COVID-19 therapies made from antibodies often are given to patients who are at high risk of severe illness and hospitalization. However, there have been nagging questions about whether such antibody therapies retain their effectiveness as worrisome new virus variants arise.

21 Jun 2021

Researchers analyze how breast implant surfaces influence immune response

Rice University bioengineers collaborated on a six-year study that systematically analyzed how the surface architecture of breast implants influences the development of adverse effects, including an unusual type of lymphoma.

21 Jun 2021

CU Cancer Center secures unique SPORE grant for head and neck cancer research

Research and treatment of head and neck cancers at the University of Colorado Cancer Center reached a new level this month with a highly competitive Specialized Programs of Research Excellence grant from the National Cancer Institute.

21 Jun 2021

Wayne State receives NIH grant for undergraduate training program in biomedical sciences

Researchers at Wayne State University recently received a nearly $1.97 million grant from the National Institute of General Medical Sciences of the National Institutes of Health for the T34 program, Maximizing Access to Research Careers (MARC).

21 Jun 2021

Researchers uncover the role of macrophages in liver growth after massive resections

RUDN University doctors found out what role macrophages play in the recovery of the liver after the removal of its significant part. The results are published in the journal Biomedicine & Pharmacotherapy.

21 Jun 2021

Discovery provides new target to make melanomas more vulnerable to anti-cancer treatments

Hypoxia, or the inadequate oxygenation of a tissue, is a condition occurring frequently in all solid tumors such as melanoma skin cancer.

21 Jun 2021

High levels of protein linked with heart health could protect against Alzheimer's-like brain damage

By the time people with Alzheimer's disease start exhibiting difficulty remembering and thinking, the disease has been developing in their brains for two decades or more, and their brain tissue already has sustained damage. As the disease progresses, the damage accumulates, and their symptoms worsen.

21 Jun 2021

New breakthrough could lead to a cure for common childhood cancer

Scientists studying a common childhood cancer have made a major breakthrough which could lead to a cure for some youngsters who would not have survived the condition.

21 Jun 2021

University of Louisville receives NIH funding to support research into liver-related illness

The University of Louisville Hepatobiology and Toxicology Center of Biomedical Research Excellence has received $11.3 million in funding from the National Institutes of Health to support its research into liver-related illness for an additional five years.

21 Jun 2021

Study shows a robust immune response to COVID-19 vaccine in breastfeeding health workers

A recent study by researchers from Poland, published in the journal Vaccines, shows how levels of IgA and IgG antibodies specific to the spike glycoprotein of SARS-CoV-2 increase in both breast milk and serum samples of mothers following vaccination against COVID-19 – with important implications for further vaccine planning endeavors.

21 Jun 2021

Could the European hedgehog be a sentinel for infectious agents and a harbinger of environmental pollution?

A recent review paper by Portuguese and Spanish authors, recently published in the journal Biologics, revealed the current state of knowledge regarding hedgehog health – most notably the presence of infectious agents, diseases and other threats that can affect the health of the population.

21 Jun 2021

Study details health risks, growth patterns, and treatment outcomes of people with achondroplasia

In a retrospective study believed to be one of the largest of its kind, researchers say they have successfully charted the health risks, growth patterns, and medical and surgical outcomes of 1,374 people with the most common form of dwarfism, called achondroplasia, seen over a 60-year period at four academic medical centers, including Johns Hopkins Medicine.

21 Jun 2021

Multivalent antibodies show high potency against SARS-CoV-2 in new study

A new study in the journal Nature Communications describes the process of converting a SARS-CoV-2 antibody into a multivalent form, thus enabling it to bind at various different points with its epitope.

21 Jun 2021

Medical Science News

What is the optimal dosing regimen for remdesivir in COVID-19 patients? A computational model

Researchers screen Chinese herbal medicines and plant compounds for anti-SARS-CoV-2 activity

The effect of novel insertion mutation in SARS-CoV-2 spike glycoprotein RNA

Does SARS-CoV-2 alter the expression of molecules involved in the homeostasis of blood pressure?

New test bed launched to advance the regenerative medicine field

New human organoid mimics the earliest developmental steps of the nervous system in embryos

Researchers decode the mechanisms of cell renewal process

Dual-antibody combination therapies effective against SARS-CoV-2 variants in animal study

Researchers analyze how breast implant surfaces influence immune response

CU Cancer Center secures unique SPORE grant for head and neck cancer research

Wayne State receives NIH grant for undergraduate training program in biomedical sciences

Researchers uncover the role of macrophages in liver growth after massive resections

Discovery provides new target to make melanomas more vulnerable to anti-cancer treatments

High levels of protein linked with heart health could protect against Alzheimer's-like brain damage

New breakthrough could lead to a cure for common childhood cancer

University of Louisville receives NIH funding to support research into liver-related illness

Study shows a robust immune response to COVID-19 vaccine in breastfeeding health workers

Could the European hedgehog be a sentinel for infectious agents and a harbinger of environmental pollution?

Study details health risks, growth patterns, and treatment outcomes of people with achondroplasia

Multivalent antibodies show high potency against SARS-CoV-2 in new study

Exploring the nanoscale: How AFM is transforming cosmetic science

Innovating Texture and Culture in Plant-Based Foods

Advancing brain microphysiological systems (bMPS)

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