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SARS-CoV-2 nucleoprotein can trigger α-synuclein amyloid fibril formation

A new study, released as a preprint on the bioRxiv* server, casts some light on the pathogenesis of acute and subacute neurological complications associated with COVID-19.

19 Apr 2021

Defects in specific goblet cells may be a factor contributing to ulcerative colitis

There are many variants of "goblet cells" in the intestines and they seem to have different functions, according to a new study from the University of Gothenburg.

19 Apr 2021

Novel mRNA delivery vehicle provides alternative to LNPs for SARS-CoV-2 vaccines

Researchers in the United States have developed an alternative messenger RNA (mRNA) delivery platform to the lipid nanoparticles that are currently used in vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).

18 Apr 2021

Higher handgrip cutoff values found to be more accurate markers of mobility limitation in older adults

Aging entails a loss of muscle mass and strength, which in some cases impairs mobility, hinders walking or performance of day-to-day tasks, and exposes the elderly to the risk of falls and hospitalizations.

17 Apr 2021

Studies suggest mRNA COVID-19 vaccine may have reduced efficacy in patients with blood cancer

Two new studies published in Blood suggest that the mRNA COVID-19 vaccine may have reduced efficacy in individuals with chronic lymphocytic leukemia (CLL) and multiple myeloma, two types of blood cancer.

17 Apr 2021

Past COVID-19 infection does not completely protect against reinfection in young people

Although antibodies induced by SARS-CoV-2 infection are largely protective, they do not completely protect against reinfection in young people, as evidenced through a longitudinal, prospective study of more than 3,000 young, healthy members of the US Marines Corps conducted by researchers at the Icahn School of Medicine at Mount Sinai and the Naval Medical Research Center, published April 15 in The Lancet Respiratory Medicine.

17 Apr 2021

Study sheds light on how tau aggregates promote Alzheimer’s disease

Look deep inside the brain of someone with Alzheimer's disease, most forms of dementia or the concussion-related syndrome known as chronic traumatic encephalopathy (CTE) and you'll find a common suspected culprit: stringy, hairball-like tangles of a protein called tau.

17 Apr 2021

Candidate coronavirus vaccines show promising results in early animal testing

A candidate vaccine that could provide protection against the COVID-19 virus and other coronaviruses has shown promising results in early animal testing.

17 Apr 2021

Experimental antiviral drug for COVID-19 shows effectiveness in hamster models

The experimental antiviral drug MK-4482 significantly decreased levels of virus and disease damage in the lungs of hamsters treated for SARS-CoV-2 infection, according to a new study from National Institutes of Health scientists.

17 Apr 2021

SARS-CoV-2 does not directly infect the brain but can inflict neurological damage

SARS-CoV-2, the virus that causes COVID-19, likely does not directly infect the brain but can still inflict significant neurological damage, according to a new study from neuropathologists, neurologists, and neuroradiologists at Columbia University Vagelos College of Physicians and Surgeons.

17 Apr 2021

Novel PET tracer is safe and can clearly identify early stages of rheumatoid arthritis

New research shows that a novel positron emission tomography (PET) tracer that targets inflammation is safe and can clearly identify early stages of rheumatoid arthritis.

17 Apr 2021

Study sheds light on how autism manifests in the brains of girls

New research has shed light on how autism-spectrum disorder (ASD) manifests in the brains of girls, prompting the scientists to warn that conclusions drawn from studies conducted primarily in boys should not be assumed to hold true for girls.

16 Apr 2021

Novel PET radiopharmaceutical shows promising results in first-in-humans study

The preliminary trial results of a novel radiopharmaceutical for PET imaging of inflammation developed at the University of Turku, Finland, have been published.

16 Apr 2021

Researchers develop an effective strategy to fight against chronic myelomonocytic leukemia

Leukemias are debilitating cancers of the hematopoietic or blood-forming cells of the bone marrow. Now, researchers at Tokyo Medical and Dental University describe an ingenious strategy against chronic myelomonocytic leukemia (CMML) wherein an antibody-drug conjugate (ADC) comprising a cytotoxic drug payload linked to an antibody that selectively targets specific cell lines effectively blocks malignant cell proliferation at source.

16 Apr 2021

Researchers identify risk factors for SARS-CoV-2 reinfection

A team of scientists from the Capital Medical University and Peking University, China, has recently explored the factors responsible for the reactivation of SARS-CoV-2 infection among individuals who have recently recovered from COVID-19. The findings reveal that individuals with lower lymphocyte count or with two or fewer symptoms during the first COVID-19 episode are at higher risk of recurrent infection.

16 Apr 2021

Numerous agents with anti-SARS-CoV-2 potential discovered with crystallographic screening

An international team of researchers focused on the macrodomain part of the non-structural protein 3 (Nsp3) gene product that SARS-CoV-2 uses to overturn the host cell’s natural antiviral response. The team provided a template that can help develop novel antivirals that are direct-acting and can combat the current pandemic.

16 Apr 2021

SARS-CoV-2 can alter bone marrow macrophage (BMM)-to-osteoclast differentiation, study finds

Now, a team of researchers in China and Australia has shown that SARS-CoV-2 infection can affect bone marrow macrophage (BMM)-to-osteoclast differentiation, which may impact the skeletal system.

16 Apr 2021

Researchers identify new targets to control angiogenesis

Angiogenesis is a process of new vessel formation that is activated both in physiological (tissue repair, reproduction, etc.) and pathological (myocardial infarction, diabetic retinopathy, cancer, etc.) conditions.

16 Apr 2021

Rapid mRNA vaccination effectively controls SARS-CoV-2 transmission in long-term care facilities

Vaccine rollouts all over the world are aimed at cutting short the coronavirus disease 2019 (COVID-19) pandemic by inducing antibody-mediated immunity to the virus. A new study, recently released on the medRxiv* preprint server, addresses the successful reduction in viral spread and case incidence among residents of long-term care facilities (LTCF).

16 Apr 2021

COVID-19 vaccination of lactating mothers elicits specific IgA antibodies in breast milk

A new study, released on the medRxiv* preprint server, examines the presence of SARS-CoV-2-specific IgA in human milk and its association with the protection of breastfed infants against the disease.

16 Apr 2021

Medical Science News

SARS-CoV-2 nucleoprotein can trigger α-synuclein amyloid fibril formation

Defects in specific goblet cells may be a factor contributing to ulcerative colitis

Novel mRNA delivery vehicle provides alternative to LNPs for SARS-CoV-2 vaccines

Higher handgrip cutoff values found to be more accurate markers of mobility limitation in older adults

Studies suggest mRNA COVID-19 vaccine may have reduced efficacy in patients with blood cancer

Past COVID-19 infection does not completely protect against reinfection in young people

Study sheds light on how tau aggregates promote Alzheimer’s disease

Candidate coronavirus vaccines show promising results in early animal testing

Experimental antiviral drug for COVID-19 shows effectiveness in hamster models

SARS-CoV-2 does not directly infect the brain but can inflict neurological damage

Novel PET tracer is safe and can clearly identify early stages of rheumatoid arthritis

Study sheds light on how autism manifests in the brains of girls

Novel PET radiopharmaceutical shows promising results in first-in-humans study

Researchers develop an effective strategy to fight against chronic myelomonocytic leukemia

Researchers identify risk factors for SARS-CoV-2 reinfection

Numerous agents with anti-SARS-CoV-2 potential discovered with crystallographic screening

SARS-CoV-2 can alter bone marrow macrophage (BMM)-to-osteoclast differentiation, study finds

Researchers identify new targets to control angiogenesis

Rapid mRNA vaccination effectively controls SARS-CoV-2 transmission in long-term care facilities

COVID-19 vaccination of lactating mothers elicits specific IgA antibodies in breast milk

Innovating Texture and Culture in Plant-Based Foods

Advancing brain microphysiological systems (bMPS)

PhD researcher at LifeArc

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