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Mutations in SARS-CoV-2 spike proteolytic cleavage sites may alter transmission dynamics

A study conducted by researchers at the University of Kentucky and the Washington University School of Medicine in the USA has revealed that mutations in the proteolytic cleavage site within the S2 subunit can alter the processing of the SARS-CoV-2 spike protein, affecting viral entry into host cells.

26 Jan 2021

Drug intervention may prevent heart damage caused by chemotherapy

There could be an intervention on the horizon to help prevent heart damage caused by the common chemotherapy drug doxorubicin, new research suggests.

26 Jan 2021

Diabetes and glucose levels tied to increased risk of COVID-19 death

Researchers at Xijing Hospital, Fourth Military Medical University, Xi’an, China, found that diabetes and on-admission glucose levels may increase the risk of COVID-19 mortality.

26 Jan 2021

SARS-CoV-2 rapidly adapts to Vero E6 cell culture propagation

Researchers at the Erasmus Medical Centre in the Netherlands and the University of Illinois at Urbana-Champaign in the US found that SARS-CoV-2 rapidly adapts to Vero E6 cell culture propagation and that this can be prevented by using cell lines with an active serine protease-mediated entry pathway.

26 Jan 2021

Study shows several peridomestic mammal species are potential spreaders of SARS-CoV-2

Researchers from the US and Australia show that several common peridomestic species (including deer mice, striped skunks and bushy-tailed woodrats) are amenable to infection with SARS-CoV-2.

26 Jan 2021

New UK SARS-CoV-2 variant circulating in US since November, says study

A new study by researchers at the Department of Ecology and Evolutionary Biology, University of Arizona, showed that the new variant has circulated in the US since November.

26 Jan 2021

New SARS-CoV-2 variant must be curbed to protect UK health services, warn experts

A new research project called REACT-1 – launched by researchers at the Imperial College London, Imperial College Healthcare NHS Trust, and Ipsos MORI – has aimed to better understand the dynamics of SARS-CoV-2’s viral spread across the UK.

26 Jan 2021

Research shows immediate phase of blood vessel restructuring after aneurysm

Hitting a pothole on the road in just the wrong way might create a bulge on the tire, a weakened spot that will almost certainly lead to an eventual flat tire. But what if that tire could immediately begin reknitting its rubber, reinforcing the bulge and preventing it from bursting?

25 Jan 2021

New partnership to develop test for predicting disease course in pediatric Crohn's patients

The Crohn's & Colitis Foundation, the leading non-profit organization focused on both research and patient support for inflammatory bowel disease (IBD), has entered into a partnership with LifeArc, an independent medical research charity that advances translation of early science into health care treatments or diagnostics, to potentially develop the first clinical lab test to predict disease course in pediatric patients with Crohn's disease and response to treatment.

25 Jan 2021

Optimistic pupils with 'happy' memories linked to lower drink and drug risk

Teenagers with happy childhood memories are likely to drink less, take fewer drugs and enjoy learning, according to research published in the peer-reviewed journal Addiction Research & Theory.

25 Jan 2021

High density of street trees may help improve mental health

Depression, especially in urban areas, is on the rise, now more than ever. Mental health outcomes are influenced by, among other things, the type of environment where one lives.

25 Jan 2021

DARPA funding brings wireless communication between brains one step closer to reality

Wireless communication directly between brains is one step closer to reality thanks to $8 million in Department of Defense follow-up funding for Rice University neuroengineers.

25 Jan 2021

Study shows link between early brainstem tau accumulation and cortical hyperexcitability

Study conducted by researchers from the GIGA CRC In vivo Imaging laboratory at ULiège demonstrates, for the first time in humans, how the first deposits of tau proteins in the brainstem are associated with neurophysiological processes specific to the early stages of Alzheimer's disease development.

25 Jan 2021

Brain stimulation highlights ancestral brain highway system shared by humans and monkeys

Scientists have identified that the evolutionary development of human and primate brains may have been similar for communication and memory.

25 Jan 2021

Missing surface protein allows small cell lung cancer cells to hide from immune defenses

Small cell lung cancer (SCLC) cells are missing a surface protein that triggers an immune response, allowing them to hide from one of the body's key cancer defenses, a new study led by UT Southwestern researchers suggests.

25 Jan 2021

COVID-19 diagnostic tests remain able to detect all published virus strains

Paris, France and Camberley, UK – 21 December 2020 – Novacyt (EURONEXT GROWTH: ALNOV; AIM: NCYT), an international specialist in clinical diagnostics, announces that following the detection of a new variant of COVID-19 by the UK’s COVID19 Genomics UK consortium, known as VUI-202012/01, the Company has carried out a detailed analysis of the mutations in this new variant and in all published COVID-19 strains to fully assess the reliability of its existing diagnostic tests.

From AFSBio 25 Jan 2021

Combining anti-tumor antibodies with standard-of-care improves therapeutic outcomes in cancer

The cover for issue 2 of Oncotarget features Figure 4, "Combination therapy TA99/ICB reduced the lung tumor burden in the B16 model of metastases," published in "Improved therapeutic efficacy of unmodified anti-tumor antibodies by immune checkpoint blockade and kinase targeted therapy in mouse models of melanoma" by Pérez-Lorenzo, et al. which reported that here, the authors showed that removing immune suppression and enhancing stimulatory signals increased the anti-tumor activity of unmodified TA99 antibodies with a significant reduction of growth of solid tumors and lung metastases in mouse models of melanoma.

25 Jan 2021

Reduced expression of TBX15 in tumor tissue represents a prognostic biomarker for HCC patients

The cover for issue 52 of Oncotarget features Figure 1, "Volcano plots of DNA methylation in tumor tissues compared with nontumor tissue," published in "Reduction of T-Box 15 gene expression in tumor tissue is a prognostic biomarker for patients with hepatocellular carcinoma" by Morine, et al. which reported that the authors conducted a genome-wide analysis of DNA methylation of the tumor and non-tumor tissue of 15 patients with Hepatocellular carcinoma (HCC), and revealed TBX15 was the most hypermethylated gene of the tumor.

25 Jan 2021

New maintenance treatment for AML shows strong benefit for patients

Patients with acute myeloid leukemia (AML), the most common form of acute leukemia in adults, that has gone into remission following initial chemotherapy remain in remission longer and have improved overall survival when they are given a pill form of the cancer drug azacitidine as a maintenance treatment, according to a randomized, international phase 3 clinical trial for which Weill Cornell Medicine and NewYork-Presbyterian are trial sites.

22 Jan 2021

Researchers identify protein that may represent a safer treatment target for pancreatic cancer

Researchers from Queen Mary University of London, have identified a protein that may represent a novel therapeutic target for the treatment of pancreatic cancer.

22 Jan 2021

Medical Science News

Mutations in SARS-CoV-2 spike proteolytic cleavage sites may alter transmission dynamics

Drug intervention may prevent heart damage caused by chemotherapy

Diabetes and glucose levels tied to increased risk of COVID-19 death

SARS-CoV-2 rapidly adapts to Vero E6 cell culture propagation

Study shows several peridomestic mammal species are potential spreaders of SARS-CoV-2

New UK SARS-CoV-2 variant circulating in US since November, says study

New SARS-CoV-2 variant must be curbed to protect UK health services, warn experts

Research shows immediate phase of blood vessel restructuring after aneurysm

New partnership to develop test for predicting disease course in pediatric Crohn's patients

Optimistic pupils with 'happy' memories linked to lower drink and drug risk

High density of street trees may help improve mental health

DARPA funding brings wireless communication between brains one step closer to reality

Study shows link between early brainstem tau accumulation and cortical hyperexcitability

Brain stimulation highlights ancestral brain highway system shared by humans and monkeys

Missing surface protein allows small cell lung cancer cells to hide from immune defenses

COVID-19 diagnostic tests remain able to detect all published virus strains

Combining anti-tumor antibodies with standard-of-care improves therapeutic outcomes in cancer

Reduced expression of TBX15 in tumor tissue represents a prognostic biomarker for HCC patients

New maintenance treatment for AML shows strong benefit for patients

Researchers identify protein that may represent a safer treatment target for pancreatic cancer

Innovating Texture and Culture in Plant-Based Foods

Advancing brain microphysiological systems (bMPS)

PhD researcher at LifeArc

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