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Marshall University researcher awarded $399,600 NIH grant to study sex differences in brain development

W. Christopher Risher, Ph.D., an assistant professor of biomedical sciences at the Marshall University Joan C. Edwards School of Medicine, has been awarded a $399,600 grant from the National Institutes of Health for his research on the differences in brain development between males and females.

12 Apr 2021

Researchers discover genetic risk factors for childhood OCD

Researchers at the University of Calgary and The Hospital for Sick Children (SickKids), in Toronto, have discovered genetic risk factors for OCD that could help pave the way for earlier diagnosis and improved treatment for children and youth.

12 Apr 2021

Exercise training may slow breast cancer growth by increasing anti-tumor immune response

Exercise training may slow tumor growth and improve outcomes for females with breast cancer - especially those treated with immunotherapy drugs - by stimulating naturally occurring immune mechanisms, researchers at Massachusetts General Hospital and Harvard Medical School have found.

12 Apr 2021

Study identifies a 'window of impairment' caused by cannabis intoxication

A comprehensive analysis of 80 scientific studies has identified a 'window of impairment' of between three and 10 hours caused by moderate to high doses of the intoxicating component of cannabis, tetrahydrocannabinol (THC).

12 Apr 2021

Yale researchers provide new insights into acquired resistance to cancer immunotherapy

New research by Yale Cancer Center shows insights into modeling resistance to immune checkpoint inhibitors, a form of cancer immunotherapy.

12 Apr 2021

Researchers receive $500,000 grant to test novel approach for restoring damaged muscles after injury

Researchers from the University of Tennessee Health Science Center have received a $500,000 grant over three years from the Department of Defense to test a novel strategy using mitochondria transplantation therapy for restoration of neuromuscular structure and function after injury.

12 Apr 2021

New test offers a simpler way to quantify the reservoir of intact viruses in HIV patients

A new test that measures the quantity and quality of inactive HIV viruses in the genes of people living with HIV may eventually give researchers a better idea of what drugs work best at curing the disease.

12 Apr 2021

Researchers reveal the positive effects of exercise on the liver

Non-alcoholic fatty liver disease (NAFLD) is the most common liver disorder worldwide, affecting as much as a quarter of humanity. It is characterized by fat accumulation in liver cells and may progress to inflammation, cirrhosis and liver failure.

12 Apr 2021

Broadly cross-reactive antibody to SARS-CoV-2 RBD with robust resistance to mutational escape

A new study addresses an urgent need – namely, a therapeutic antibody directed specifically against a key SARS-CoV-2 antigen which is highly conserved among similar viruses, and is not easily bypassed by viral escape mutations.

12 Apr 2021

Small molecule inhibitors of SARS-CoV-2 identified by screening

A new study describes the identification of small molecule inhibitors that block the catalytic activity of the crucial viral non-structural protein 5 (nsp5), using a large-scale screening method.

12 Apr 2021

P681 mutation has little impact on transmissibility in the SARS-CoV-2 UK variant, finds study

A new preprint, recently released on the bioRxiv* server, explores the impact of a single mutation, the P681H mutation, on the transmissibility of the virus.

12 Apr 2021

Current hygiene guidelines appropriate for UK and SA variants of SARS-CoV-2, study finds

Many different variants and lineages have arisen from the ancestral Wuhan-Hu1 strain of the SARS-CoV-2. This requires careful attention to control measures since many are more infective and transmissible than the older strains. A recent study compares the UK variant of this virus with the wildtype in terms of susceptibility to routine cleaning and disinfection measures.

12 Apr 2021

Researchers provide ultrastructural details of SARS-CoV-2-infected respiratory epithelial cells

A team of scientists from the United Kingdom recently investigated the ultrastructural details of the attachment, entry, and budding processes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the human airway epithelium. They have used a highly differentiated air-liquid interface cultures of airway epithelium to thoroughly investigate the viral infection cycle. The study is currently available on the bioRxiv* preprint server.

12 Apr 2021

Researchers explore an inhalable SARS-CoV-2 nanobody therapy

Even as vaccines against SARS-CoV-2 are being developed and administered at an unprecedented pace, treating this infection remains a challenge. To address this, researchers from China have used nanobodies (Nb) as a possible therapeutic approach. They reported Nb phage display libraries derived from four camels immunized with the SARS-CoV-2 spike RBD.

12 Apr 2021

Imbalanced bacterial community in the gums linked to Alzheimer's disease biomarker

Older adults with more harmful than healthy bacteria in their gums are more likely to have evidence for amyloid beta--a key biomarker for Alzheimer's disease--in their cerebrospinal fluid (CSF), according to new research from NYU College of Dentistry and Weill Cornell Medicine.

12 Apr 2021

A shared set of systems in the brain may be vital for controlling the retrieval of facts and memories

A shared set of systems in the brain may play an important role in controlling the retrieval of facts and personal memories utilized in everyday life, new research shows.

12 Apr 2021

Researchers work to develop dual antigen COVID-19 vaccine candidate

A new study has been published on the medRxiv* preprint server, which focuses on the development of a dual-antigen COVID-19' T cell' vaccine. This vaccine is developed based on the expression of both S protein and nucleocapsid (N) protein of SARS-CoV-2, using a next-generation human adenovirus serotype 5 (Ad5) platform.

12 Apr 2021

Could N protein-based COVID-19 vaccines hinder SARS-CoV-2's NK cell inhibition?

Upon SARS-CoV-2 infection, what are the changes occurring on the surface of the host cell? To address this, and a team of researchers undertook a study exploring the natural killer (NK) cells and their role during a SARS-CoV-2 infection.

12 Apr 2021

Tapeworm infection drug blocks SARS-CoV-2 damage in the lungs

New research published in the journal Nature found the presence of SARS-CoV-2 in the lungs resulted in abnormal pneumocytes and spike protein-mediated cell fusion. Their findings also showed that TMEM16F protein activation induces cell fusion. Therefore, drugs inhibiting the TMEM16F/Anoctamin6 calcium-activated ion channel, such as niclosamide, could serve as potential treatments for reducing the severity of COVID-19 infection.

12 Apr 2021

Mutant KRAS and P53 promote growth and metastasis of pancreatic cancer

Researchers at The University of Texas MD Anderson Cancer Center have discovered that mutant KRAS and p53, the most frequently mutated genes in pancreatic cancer, interact through the CREB1 protein to promote metastasis and tumor growth.

12 Apr 2021

Medical Science News

Marshall University researcher awarded $399,600 NIH grant to study sex differences in brain development

Researchers discover genetic risk factors for childhood OCD

Exercise training may slow breast cancer growth by increasing anti-tumor immune response

Study identifies a 'window of impairment' caused by cannabis intoxication

Yale researchers provide new insights into acquired resistance to cancer immunotherapy

Researchers receive $500,000 grant to test novel approach for restoring damaged muscles after injury

New test offers a simpler way to quantify the reservoir of intact viruses in HIV patients

Researchers reveal the positive effects of exercise on the liver

Broadly cross-reactive antibody to SARS-CoV-2 RBD with robust resistance to mutational escape

Small molecule inhibitors of SARS-CoV-2 identified by screening

P681 mutation has little impact on transmissibility in the SARS-CoV-2 UK variant, finds study

Current hygiene guidelines appropriate for UK and SA variants of SARS-CoV-2, study finds

Researchers provide ultrastructural details of SARS-CoV-2-infected respiratory epithelial cells

Researchers explore an inhalable SARS-CoV-2 nanobody therapy

Imbalanced bacterial community in the gums linked to Alzheimer's disease biomarker

A shared set of systems in the brain may be vital for controlling the retrieval of facts and memories

Researchers work to develop dual antigen COVID-19 vaccine candidate

Could N protein-based COVID-19 vaccines hinder SARS-CoV-2's NK cell inhibition?

Tapeworm infection drug blocks SARS-CoV-2 damage in the lungs

Mutant KRAS and P53 promote growth and metastasis of pancreatic cancer

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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